5HT2A_DROME
ID 5HT2A_DROME Reviewed; 834 AA.
AC P28285; Q0E921; Q4QQC9; Q5MTE9; Q5MTF1; Q5MTF2; Q5MTF3; Q5MTF8; Q5MTF9;
AC Q5MTG0; Q5MTG1; Q5MTG2; Q5MTG3; Q5MTG4; Q5MTG6; Q5MTG9; Q5MTH1; Q5MTH2;
AC Q5MTH5; Q5MTH6; Q5MTH7; Q5MTH9; Q5MTI0; Q5MTI1; Q5MTI4; Q5MTI6; Q5MTI7;
AC Q5MTI8; Q5MTJ0; Q5MTJ4; Q5MTJ5; Q5MTJ6; Q5MTJ9; Q5MTK5; Q5MTL1; Q5MTL5;
AC Q5MTL6; Q5MTM2; Q5MTM5; Q5MTM8; Q5MTN6; Q5MTQ1; Q5MTQ4; Q5MTR1; Q5MTR3;
AC Q5MTR6; Q5MTR8; Q5MTS1; Q5MTT8; Q5MTV6; Q5MTV7; Q5MTV9; Q5MTW8; Q5MTX2;
AC Q5MTX7; Q5MTY3; Q5MTY7; Q5MTY8; Q5MTY9; Q5MTZ0; Q5MTZ6; Q5MUJ0; Q5MUK2;
AC Q5MUK5; Q5MUK8; Q5MUL0; Q5MUL2; Q5MUL5; Q5MUM3; Q5MUM7; Q5MUM9; Q5MUN0;
AC Q5MUN1; Q5MUN2; Q5MUP0; Q5MUP5; Q5MUP6; Q5MUP7; Q5MUP8; Q5MUQ1; Q5MUQ6;
AC Q5MUQ7; Q5MUQ8; Q5MUQ9; Q5MUR1; Q5MUR2; Q5MUR3; Q5MUR4; Q5MUR5; Q5MUT3;
AC Q5MUT4; Q5MUT7; Q5MUT9; Q5MUU2; Q5MUU5; Q5MUU6; Q5MUV4; Q5MUV5; Q5MUV8;
AC Q5MUV9; Q5MUW3; Q5MUW4; Q5MUW7; Q5MUX4; Q5MUX6; Q5MUY1; Q5MUY3; Q5MV05;
AC Q5MV06; Q5MV07; Q5MV08; Q5MV13; Q5MV14; Q5MV15; Q5MV26; Q5MV30; Q9V8Q9;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=5-hydroxytryptamine receptor 2A;
DE Short=5-HT receptor 2A;
DE AltName: Full=Serotonin receptor 2A;
GN Name=5-HT1A; Synonyms=5HT-R2A; ORFNames=CG16720;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ALA-96 AND ASN-196.
RC STRAIN=Canton-S, and Oregon-R; TISSUE=Head;
RX PubMed=1310937; DOI=10.1002/j.1460-2075.1992.tb05021.x;
RA Saudou F., Boschert U., Amlaiky N., Plassat J.-L., Hen R.;
RT "A family of Drosophila serotonin receptors with distinct intracellular
RT signalling properties and expression patterns.";
RL EMBO J. 11:7-17(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-588.
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-588.
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-242, NUCLEOTIDE SEQUENCE [GENOMIC
RP DNA] OF 511-834, AND VARIANTS 29-GLU--PRO-32 DEL; GLN-46; VAL-49; GLU-51;
RP GLU-52; GLY-54; THR-76; THR-86; GLN-91; ALA-96; THR-143; THR-146; VAL-171;
RP ASP-182; TYR-184; ASN-196; HIS-198; GLY-213; LEU-531; ALA-536;
RP 547-ALA--GLY-550 DELINS GLY-PRO-MET-GLY-PRO-LEU; VAL-571; LYS-585; MET-588;
RP ARG-589; VAL-648; PRO-657; TRP-682; ILE-688; THR-692; THR-706; HIS-716;
RP GLN-HIS-716 INS; 716-GLN-GLN-717 DEL; 716-GLN--GLN-718 DEL AND
RP 717-GLN--GLN-719 DELINS HIS.
RC STRAIN=CA-001, CA-002, CA-003, CA-008, CA-009, CA-010, CA-011, CA-012,
RC CA-013, CA-015, CA-017, CA-018, CA-023, CA-026, CA-027, CA-030, CA-031,
RC CA-033, CA-034, CA-035, CA-037, CA-040, CA-041, CA-043, CA-044, CA-045,
RC CA-046, CA-047, CA-048, CA-052, CA-055, CA-056, CA-057, CA-058, CA-060,
RC CA-061, CA-062, CA-063, CA-064, CA-065, CA-066, CA-068, CA-069, CA-070,
RC CA-072, CA-073, CA-075, CA-081, CA-083, CA-086, CA-087, CA-088, CA-089,
RC CA-090, CA-091, CA-093, CA-095, CA-096, CA-100, CA-105, CA-113, CA-114,
RC CA-115, CA-118, CA-120, CA-123, CA-126, CA-127, CA-128, CA-129, CA-130,
RC CA-132, CA-133, CA-136, CA-137, CA-140, CA-142, CA-144, CA-145, CA-147,
RC CA-148, NC-001, NC-002, NC-003, NC-004, NC-005, NC-006, NC-008, NC-010,
RC NC-011, NC-012, NC-013, NC-014, NC-015, NC-017, NC-021, NC-022, NC-023,
RC NC-024, NC-025, NC-026, NC-027, NC-028, NC-029, NC-030, NC-032, NC-033,
RC NC-034, NC-036, NC-037, NC-038, NC-039, NC-040, NC-041, NC-042, NC-043,
RC NC-044, NC-046, NC-047, NC-048, NC-049, NC-050, NC-051, NC-052, NC-053,
RC NC-054, NC-057, NC-058, NC-059, NC-060, NC-061, NC-064, NC-066, NC-067,
RC NC-068, NC-069, NC-070, NC-071, NC-072, NC-073, NC-074, NC-075, NC-077,
RC NC-079, NC-080, NC-081, NC-084, NC-086, NC-087, NC-088, NC-089, NC-091,
RC NC-092, NC-094, NC-095, NC-096, NC-097, NC-098, NC-100, NC-101, NC-103,
RC NC-104, NC-105, NC-107, NC-108, NC-109, NC-110, NC-111, NC-112, NC-113,
RC NC-114, NC-115, NC-116, NC-118, NC-119, NC-121, NC-123, NC-124, NC-125,
RC NC-126, NC-127, NC-128, NC-129, NC-131, NC-133, NC-134, NC-135, NC-136,
RC NC-137, NC-138, NC-139, NC-141, NC-142, NC-144, NC-146, NC-147, NC-148,
RC NC-149, and NC-150;
RX PubMed=15611167; DOI=10.1534/genetics.104.028712;
RA Nikoh N., Duty A., Gibson G.;
RT "Effects of population structure and sex on association between serotonin
RT receptors and Drosophila heart rate.";
RL Genetics 168:1963-1974(2004).
CC -!- FUNCTION: This is one of the several different receptors for 5-
CC hydroxytryptamine (serotonin), a biogenic hormone that functions as a
CC neurotransmitter, a hormone, and a mitogen. The activity of this
CC receptor is mediated by G proteins which inhibit adenylate cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAY84887.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; Z11489; CAA77570.1; -; mRNA.
DR EMBL; AE013599; AAF57603.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68432.1; -; Genomic_DNA.
DR EMBL; BT023487; AAY84887.1; ALT_SEQ; mRNA.
DR EMBL; AY564785; AAS73796.1; -; Genomic_DNA.
DR EMBL; AY564786; AAS73797.1; -; Genomic_DNA.
DR EMBL; AY564787; AAS73798.1; -; Genomic_DNA.
DR EMBL; AY564788; AAS73799.1; -; Genomic_DNA.
DR EMBL; AY564789; AAS73800.1; -; Genomic_DNA.
DR EMBL; AY564790; AAS73801.1; -; Genomic_DNA.
DR EMBL; AY564791; AAS73802.1; -; Genomic_DNA.
DR EMBL; AY564792; AAS73803.1; -; Genomic_DNA.
DR EMBL; AY564793; AAS73804.1; -; Genomic_DNA.
DR EMBL; AY564794; AAS73805.1; -; Genomic_DNA.
DR EMBL; AY564795; AAS73806.1; -; Genomic_DNA.
DR EMBL; AY564796; AAS73807.1; -; Genomic_DNA.
DR EMBL; AY564797; AAS73808.1; -; Genomic_DNA.
DR EMBL; AY564798; AAS73809.1; -; Genomic_DNA.
DR EMBL; AY564799; AAS73810.1; -; Genomic_DNA.
DR EMBL; AY564800; AAS73811.1; -; Genomic_DNA.
DR EMBL; AY564801; AAS73812.1; -; Genomic_DNA.
DR EMBL; AY564802; AAS73813.1; -; Genomic_DNA.
DR EMBL; AY564803; AAS73814.1; -; Genomic_DNA.
DR EMBL; AY564804; AAS73815.1; -; Genomic_DNA.
DR EMBL; AY564805; AAS73816.1; -; Genomic_DNA.
DR EMBL; AY564806; AAS73817.1; -; Genomic_DNA.
DR EMBL; AY564807; AAS73818.1; -; Genomic_DNA.
DR EMBL; AY564808; AAS73819.1; -; Genomic_DNA.
DR EMBL; AY564809; AAS73820.1; -; Genomic_DNA.
DR EMBL; AY564810; AAS73821.1; -; Genomic_DNA.
DR EMBL; AY564811; AAS73822.1; -; Genomic_DNA.
DR EMBL; AY564812; AAS73823.1; -; Genomic_DNA.
DR EMBL; AY564813; AAS73824.1; -; Genomic_DNA.
DR EMBL; AY564814; AAS73825.1; -; Genomic_DNA.
DR EMBL; AY564815; AAS73826.1; -; Genomic_DNA.
DR EMBL; AY564816; AAS73827.1; -; Genomic_DNA.
DR EMBL; AY564817; AAS73828.1; -; Genomic_DNA.
DR EMBL; AY564818; AAS73829.1; -; Genomic_DNA.
DR EMBL; AY564819; AAS73830.1; -; Genomic_DNA.
DR EMBL; AY564820; AAS73831.1; -; Genomic_DNA.
DR EMBL; AY564821; AAS73832.1; -; Genomic_DNA.
DR EMBL; AY564822; AAS73833.1; -; Genomic_DNA.
DR EMBL; AY564823; AAS73834.1; -; Genomic_DNA.
DR EMBL; AY564824; AAS73835.1; -; Genomic_DNA.
DR EMBL; AY564825; AAS73836.1; -; Genomic_DNA.
DR EMBL; AY564826; AAS73837.1; -; Genomic_DNA.
DR EMBL; AY564827; AAS73838.1; -; Genomic_DNA.
DR EMBL; AY564828; AAS73839.1; -; Genomic_DNA.
DR EMBL; AY564829; AAS73840.1; -; Genomic_DNA.
DR EMBL; AY564830; AAS73841.1; -; Genomic_DNA.
DR EMBL; AY564831; AAS73842.1; -; Genomic_DNA.
DR EMBL; AY564832; AAS73843.1; -; Genomic_DNA.
DR EMBL; AY564833; AAS73844.1; -; Genomic_DNA.
DR EMBL; AY564834; AAS73845.1; -; Genomic_DNA.
DR EMBL; AY564835; AAS73846.1; -; Genomic_DNA.
DR EMBL; AY564836; AAS73847.1; -; Genomic_DNA.
DR EMBL; AY564837; AAS73848.1; -; Genomic_DNA.
DR EMBL; AY564838; AAS73849.1; -; Genomic_DNA.
DR EMBL; AY564839; AAS73850.1; -; Genomic_DNA.
DR EMBL; AY564840; AAS73851.1; -; Genomic_DNA.
DR EMBL; AY564841; AAS73852.1; -; Genomic_DNA.
DR EMBL; AY564842; AAS73853.1; -; Genomic_DNA.
DR EMBL; AY564843; AAS73854.1; -; Genomic_DNA.
DR EMBL; AY564844; AAS73855.1; -; Genomic_DNA.
DR EMBL; AY564845; AAS73856.1; -; Genomic_DNA.
DR EMBL; AY564846; AAS73857.1; -; Genomic_DNA.
DR EMBL; AY564847; AAS73858.1; -; Genomic_DNA.
DR EMBL; AY564848; AAS73859.1; -; Genomic_DNA.
DR EMBL; AY564849; AAS73860.1; -; Genomic_DNA.
DR EMBL; AY564850; AAS73861.1; -; Genomic_DNA.
DR EMBL; AY564851; AAS73862.1; -; Genomic_DNA.
DR EMBL; AY564852; AAS73863.1; -; Genomic_DNA.
DR EMBL; AY564853; AAS73864.1; -; Genomic_DNA.
DR EMBL; AY564854; AAS73865.1; -; Genomic_DNA.
DR EMBL; AY564855; AAS73866.1; -; Genomic_DNA.
DR EMBL; AY564856; AAS73867.1; -; Genomic_DNA.
DR EMBL; AY564857; AAS73868.1; -; Genomic_DNA.
DR EMBL; AY564858; AAS73869.1; -; Genomic_DNA.
DR EMBL; AY564859; AAS73870.1; -; Genomic_DNA.
DR EMBL; AY564860; AAS73871.1; -; Genomic_DNA.
DR EMBL; AY564861; AAS73872.1; -; Genomic_DNA.
DR EMBL; AY564862; AAS73873.1; -; Genomic_DNA.
DR EMBL; AY564863; AAS73874.1; -; Genomic_DNA.
DR EMBL; AY564864; AAS73875.1; -; Genomic_DNA.
DR EMBL; AY564865; AAS73876.1; -; Genomic_DNA.
DR EMBL; AY564866; AAS73877.1; -; Genomic_DNA.
DR EMBL; AY564867; AAS73878.1; -; Genomic_DNA.
DR EMBL; AY564868; AAS73879.1; -; Genomic_DNA.
DR EMBL; AY564869; AAS73880.1; -; Genomic_DNA.
DR EMBL; AY564870; AAS73881.1; -; Genomic_DNA.
DR EMBL; AY564871; AAS73882.1; -; Genomic_DNA.
DR EMBL; AY564872; AAS73883.1; -; Genomic_DNA.
DR EMBL; AY564873; AAS73884.1; -; Genomic_DNA.
DR EMBL; AY564874; AAS73885.1; -; Genomic_DNA.
DR EMBL; AY564875; AAS73886.1; -; Genomic_DNA.
DR EMBL; AY564876; AAS73887.1; -; Genomic_DNA.
DR EMBL; AY564877; AAS73888.1; -; Genomic_DNA.
DR EMBL; AY564878; AAS73889.1; -; Genomic_DNA.
DR EMBL; AY564879; AAS73890.1; -; Genomic_DNA.
DR EMBL; AY564880; AAS73891.1; -; Genomic_DNA.
DR EMBL; AY564881; AAS73892.1; -; Genomic_DNA.
DR EMBL; AY564882; AAS73893.1; -; Genomic_DNA.
DR EMBL; AY564883; AAS73894.1; -; Genomic_DNA.
DR EMBL; AY564884; AAS73895.1; -; Genomic_DNA.
DR EMBL; AY564885; AAS73896.1; -; Genomic_DNA.
DR EMBL; AY564886; AAS73897.1; -; Genomic_DNA.
DR EMBL; AY564887; AAS73898.1; -; Genomic_DNA.
DR EMBL; AY564888; AAS73899.1; -; Genomic_DNA.
DR EMBL; AY564889; AAS73900.1; -; Genomic_DNA.
DR EMBL; AY564890; AAS73901.1; -; Genomic_DNA.
DR EMBL; AY564891; AAS73902.1; -; Genomic_DNA.
DR EMBL; AY564892; AAS73903.1; -; Genomic_DNA.
DR EMBL; AY564893; AAS73904.1; -; Genomic_DNA.
DR EMBL; AY564894; AAS73905.1; -; Genomic_DNA.
DR EMBL; AY564895; AAS73906.1; -; Genomic_DNA.
DR EMBL; AY564896; AAS73907.1; -; Genomic_DNA.
DR EMBL; AY564897; AAS73908.1; -; Genomic_DNA.
DR EMBL; AY564898; AAS73909.1; -; Genomic_DNA.
DR EMBL; AY564899; AAS73910.1; -; Genomic_DNA.
DR EMBL; AY564900; AAS73911.1; -; Genomic_DNA.
DR EMBL; AY564901; AAS73912.1; -; Genomic_DNA.
DR EMBL; AY564902; AAS73913.1; -; Genomic_DNA.
DR EMBL; AY564903; AAS73914.1; -; Genomic_DNA.
DR EMBL; AY564904; AAS73915.1; -; Genomic_DNA.
DR EMBL; AY564905; AAS73916.1; -; Genomic_DNA.
DR EMBL; AY564906; AAS73917.1; -; Genomic_DNA.
DR EMBL; AY564907; AAS73918.1; -; Genomic_DNA.
DR EMBL; AY564908; AAS73919.1; -; Genomic_DNA.
DR EMBL; AY564909; AAS73920.1; -; Genomic_DNA.
DR EMBL; AY564910; AAS73921.1; -; Genomic_DNA.
DR EMBL; AY564911; AAS73922.1; -; Genomic_DNA.
DR EMBL; AY564912; AAS73923.1; -; Genomic_DNA.
DR EMBL; AY564913; AAS73924.1; -; Genomic_DNA.
DR EMBL; AY564914; AAS73925.1; -; Genomic_DNA.
DR EMBL; AY564915; AAS73926.1; -; Genomic_DNA.
DR EMBL; AY564916; AAS73927.1; -; Genomic_DNA.
DR EMBL; AY564917; AAS73928.1; -; Genomic_DNA.
DR EMBL; AY564918; AAS73929.1; -; Genomic_DNA.
DR EMBL; AY564919; AAS73930.1; -; Genomic_DNA.
DR EMBL; AY564920; AAS73931.1; -; Genomic_DNA.
DR EMBL; AY564921; AAS73932.1; -; Genomic_DNA.
DR EMBL; AY564922; AAS73933.1; -; Genomic_DNA.
DR EMBL; AY564925; AAS73936.1; -; Genomic_DNA.
DR EMBL; AY564926; AAS73937.1; -; Genomic_DNA.
DR EMBL; AY564927; AAS73938.1; -; Genomic_DNA.
DR EMBL; AY564928; AAS73939.1; -; Genomic_DNA.
DR EMBL; AY564929; AAS73940.1; -; Genomic_DNA.
DR EMBL; AY564930; AAS73941.1; -; Genomic_DNA.
DR EMBL; AY564931; AAS73942.1; -; Genomic_DNA.
DR EMBL; AY564932; AAS73943.1; -; Genomic_DNA.
DR EMBL; AY564933; AAS73944.1; -; Genomic_DNA.
DR EMBL; AY564934; AAS73945.1; -; Genomic_DNA.
DR EMBL; AY564935; AAS73946.1; -; Genomic_DNA.
DR EMBL; AY564936; AAS73947.1; -; Genomic_DNA.
DR EMBL; AY564937; AAS73948.1; -; Genomic_DNA.
DR EMBL; AY564938; AAS73949.1; -; Genomic_DNA.
DR EMBL; AY564939; AAS73950.1; -; Genomic_DNA.
DR EMBL; AY564940; AAS73951.1; -; Genomic_DNA.
DR EMBL; AY564941; AAS73952.1; -; Genomic_DNA.
DR EMBL; AY564942; AAS73953.1; -; Genomic_DNA.
DR EMBL; AY564943; AAS73954.1; -; Genomic_DNA.
DR EMBL; AY564944; AAS73955.1; -; Genomic_DNA.
DR EMBL; AY564945; AAS73956.1; -; Genomic_DNA.
DR EMBL; AY564946; AAS73957.1; -; Genomic_DNA.
DR EMBL; AY564947; AAS73958.1; -; Genomic_DNA.
DR EMBL; AY564948; AAS73959.1; -; Genomic_DNA.
DR EMBL; AY564949; AAS73960.1; -; Genomic_DNA.
DR EMBL; AY564950; AAS73961.1; -; Genomic_DNA.
DR EMBL; AY564951; AAS73962.1; -; Genomic_DNA.
DR EMBL; AY564952; AAS73963.1; -; Genomic_DNA.
DR EMBL; AY564953; AAS73964.1; -; Genomic_DNA.
DR EMBL; AY564954; AAS73965.1; -; Genomic_DNA.
DR EMBL; AY564955; AAS73966.1; -; Genomic_DNA.
DR EMBL; AY564956; AAS73967.1; -; Genomic_DNA.
DR EMBL; AY564958; AAS73968.1; -; Genomic_DNA.
DR EMBL; AY564959; AAS73969.1; -; Genomic_DNA.
DR EMBL; AY564960; AAS73970.1; -; Genomic_DNA.
DR EMBL; AY564961; AAS73971.1; -; Genomic_DNA.
DR EMBL; AY564962; AAS73972.1; -; Genomic_DNA.
DR EMBL; AY564963; AAS73973.1; -; Genomic_DNA.
DR EMBL; AY564964; AAS73974.1; -; Genomic_DNA.
DR EMBL; AY564965; AAS73975.1; -; Genomic_DNA.
DR EMBL; AY564966; AAS73976.1; -; Genomic_DNA.
DR EMBL; AY564967; AAS73977.1; -; Genomic_DNA.
DR EMBL; AY564968; AAS73978.1; -; Genomic_DNA.
DR EMBL; AY564969; AAS73979.1; -; Genomic_DNA.
DR EMBL; AY564971; AAS73981.1; -; Genomic_DNA.
DR EMBL; AY564972; AAS73982.1; -; Genomic_DNA.
DR EMBL; AY564973; AAS73983.1; -; Genomic_DNA.
DR EMBL; AY564974; AAS73984.1; -; Genomic_DNA.
DR EMBL; AY564975; AAS73985.1; -; Genomic_DNA.
DR EMBL; AY564976; AAS73986.1; -; Genomic_DNA.
DR EMBL; AY564977; AAS73987.1; -; Genomic_DNA.
DR EMBL; AY565171; AAS74181.1; -; Genomic_DNA.
DR EMBL; AY565172; AAS74182.1; -; Genomic_DNA.
DR EMBL; AY565173; AAS74183.1; -; Genomic_DNA.
DR EMBL; AY565174; AAS74184.1; -; Genomic_DNA.
DR EMBL; AY565175; AAS74185.1; -; Genomic_DNA.
DR EMBL; AY565176; AAS74186.1; -; Genomic_DNA.
DR EMBL; AY565177; AAS74187.1; -; Genomic_DNA.
DR EMBL; AY565178; AAS74188.1; -; Genomic_DNA.
DR EMBL; AY565179; AAS74189.1; -; Genomic_DNA.
DR EMBL; AY565180; AAS74190.1; -; Genomic_DNA.
DR EMBL; AY565181; AAS74191.1; -; Genomic_DNA.
DR EMBL; AY565182; AAS74192.1; -; Genomic_DNA.
DR EMBL; AY565183; AAS74193.1; -; Genomic_DNA.
DR EMBL; AY565184; AAS74194.1; -; Genomic_DNA.
DR EMBL; AY565185; AAS74195.1; -; Genomic_DNA.
DR EMBL; AY565186; AAS74196.1; -; Genomic_DNA.
DR EMBL; AY565187; AAS74197.1; -; Genomic_DNA.
DR EMBL; AY565188; AAS74198.1; -; Genomic_DNA.
DR EMBL; AY565189; AAS74199.1; -; Genomic_DNA.
DR EMBL; AY565190; AAS74200.1; -; Genomic_DNA.
DR EMBL; AY565191; AAS74201.1; -; Genomic_DNA.
DR EMBL; AY565192; AAS74202.1; -; Genomic_DNA.
DR EMBL; AY565193; AAS74203.1; -; Genomic_DNA.
DR EMBL; AY565194; AAS74204.1; -; Genomic_DNA.
DR EMBL; AY565195; AAS74205.1; -; Genomic_DNA.
DR EMBL; AY565196; AAS74206.1; -; Genomic_DNA.
DR EMBL; AY565197; AAS74207.1; -; Genomic_DNA.
DR EMBL; AY565198; AAS74208.1; -; Genomic_DNA.
DR EMBL; AY565199; AAS74209.1; -; Genomic_DNA.
DR EMBL; AY565200; AAS74210.1; -; Genomic_DNA.
DR EMBL; AY565201; AAS74211.1; -; Genomic_DNA.
DR EMBL; AY565202; AAS74212.1; -; Genomic_DNA.
DR EMBL; AY565203; AAS74213.1; -; Genomic_DNA.
DR EMBL; AY565204; AAS74214.1; -; Genomic_DNA.
DR EMBL; AY565205; AAS74215.1; -; Genomic_DNA.
DR EMBL; AY565206; AAS74216.1; -; Genomic_DNA.
DR EMBL; AY565207; AAS74217.1; -; Genomic_DNA.
DR EMBL; AY565208; AAS74218.1; -; Genomic_DNA.
DR EMBL; AY565209; AAS74219.1; -; Genomic_DNA.
DR EMBL; AY565210; AAS74220.1; -; Genomic_DNA.
DR EMBL; AY565211; AAS74221.1; -; Genomic_DNA.
DR EMBL; AY565212; AAS74222.1; -; Genomic_DNA.
DR EMBL; AY565213; AAS74223.1; -; Genomic_DNA.
DR EMBL; AY565214; AAS74224.1; -; Genomic_DNA.
DR EMBL; AY565215; AAS74225.1; -; Genomic_DNA.
DR EMBL; AY565216; AAS74226.1; -; Genomic_DNA.
DR EMBL; AY565217; AAS74227.1; -; Genomic_DNA.
DR EMBL; AY565218; AAS74228.1; -; Genomic_DNA.
DR EMBL; AY565219; AAS74229.1; -; Genomic_DNA.
DR EMBL; AY565220; AAS74230.1; -; Genomic_DNA.
DR EMBL; AY565221; AAS74231.1; -; Genomic_DNA.
DR EMBL; AY565222; AAS74232.1; -; Genomic_DNA.
DR EMBL; AY565223; AAS74233.1; -; Genomic_DNA.
DR EMBL; AY565224; AAS74234.1; -; Genomic_DNA.
DR EMBL; AY565225; AAS74235.1; -; Genomic_DNA.
DR EMBL; AY565226; AAS74236.1; -; Genomic_DNA.
DR EMBL; AY565227; AAS74237.1; -; Genomic_DNA.
DR EMBL; AY565228; AAS74238.1; -; Genomic_DNA.
DR EMBL; AY565229; AAS74239.1; -; Genomic_DNA.
DR EMBL; AY565230; AAS74240.1; -; Genomic_DNA.
DR EMBL; AY565231; AAS74241.1; -; Genomic_DNA.
DR EMBL; AY565232; AAS74242.1; -; Genomic_DNA.
DR EMBL; AY565233; AAS74243.1; -; Genomic_DNA.
DR EMBL; AY565234; AAS74244.1; -; Genomic_DNA.
DR EMBL; AY565235; AAS74245.1; -; Genomic_DNA.
DR EMBL; AY565236; AAS74246.1; -; Genomic_DNA.
DR EMBL; AY565237; AAS74247.1; -; Genomic_DNA.
DR EMBL; AY565238; AAS74248.1; -; Genomic_DNA.
DR EMBL; AY565239; AAS74249.1; -; Genomic_DNA.
DR EMBL; AY565240; AAS74250.1; -; Genomic_DNA.
DR EMBL; AY565241; AAS74251.1; -; Genomic_DNA.
DR EMBL; AY565242; AAS74252.1; -; Genomic_DNA.
DR EMBL; AY565243; AAS74253.1; -; Genomic_DNA.
DR EMBL; AY565244; AAS74254.1; -; Genomic_DNA.
DR EMBL; AY565245; AAS74255.1; -; Genomic_DNA.
DR EMBL; AY565246; AAS74256.1; -; Genomic_DNA.
DR EMBL; AY565247; AAS74257.1; -; Genomic_DNA.
DR EMBL; AY565248; AAS74258.1; -; Genomic_DNA.
DR EMBL; AY565249; AAS74259.1; -; Genomic_DNA.
DR EMBL; AY565250; AAS74260.1; -; Genomic_DNA.
DR EMBL; AY565251; AAS74261.1; -; Genomic_DNA.
DR EMBL; AY565252; AAS74262.1; -; Genomic_DNA.
DR EMBL; AY565253; AAS74263.1; -; Genomic_DNA.
DR EMBL; AY565254; AAS74264.1; -; Genomic_DNA.
DR EMBL; AY565255; AAS74265.1; -; Genomic_DNA.
DR EMBL; AY565256; AAS74266.1; -; Genomic_DNA.
DR EMBL; AY565257; AAS74267.1; -; Genomic_DNA.
DR EMBL; AY565258; AAS74268.1; -; Genomic_DNA.
DR EMBL; AY565259; AAS74269.1; -; Genomic_DNA.
DR EMBL; AY565260; AAS74270.1; -; Genomic_DNA.
DR EMBL; AY565261; AAS74271.1; -; Genomic_DNA.
DR EMBL; AY565262; AAS74272.1; -; Genomic_DNA.
DR EMBL; AY565263; AAS74273.1; -; Genomic_DNA.
DR EMBL; AY565264; AAS74274.1; -; Genomic_DNA.
DR EMBL; AY565265; AAS74275.1; -; Genomic_DNA.
DR EMBL; AY565266; AAS74276.1; -; Genomic_DNA.
DR EMBL; AY565267; AAS74277.1; -; Genomic_DNA.
DR EMBL; AY565268; AAS74278.1; -; Genomic_DNA.
DR EMBL; AY565269; AAS74279.1; -; Genomic_DNA.
DR EMBL; AY565270; AAS74280.1; -; Genomic_DNA.
DR EMBL; AY565271; AAS74281.1; -; Genomic_DNA.
DR EMBL; AY565272; AAS74282.1; -; Genomic_DNA.
DR EMBL; AY565273; AAS74283.1; -; Genomic_DNA.
DR EMBL; AY565274; AAS74284.1; -; Genomic_DNA.
DR EMBL; AY565275; AAS74285.1; -; Genomic_DNA.
DR EMBL; AY565276; AAS74286.1; -; Genomic_DNA.
DR EMBL; AY565277; AAS74287.1; -; Genomic_DNA.
DR EMBL; AY565278; AAS74288.1; -; Genomic_DNA.
DR EMBL; AY565279; AAS74289.1; -; Genomic_DNA.
DR EMBL; AY565280; AAS74290.1; -; Genomic_DNA.
DR EMBL; AY565281; AAS74291.1; -; Genomic_DNA.
DR EMBL; AY565282; AAS74292.1; -; Genomic_DNA.
DR EMBL; AY565283; AAS74293.1; -; Genomic_DNA.
DR EMBL; AY565284; AAS74294.1; -; Genomic_DNA.
DR EMBL; AY565285; AAS74295.1; -; Genomic_DNA.
DR EMBL; AY565286; AAS74296.1; -; Genomic_DNA.
DR EMBL; AY565287; AAS74297.1; -; Genomic_DNA.
DR EMBL; AY565288; AAS74298.1; -; Genomic_DNA.
DR EMBL; AY565289; AAS74299.1; -; Genomic_DNA.
DR EMBL; AY565290; AAS74300.1; -; Genomic_DNA.
DR EMBL; AY565291; AAS74301.1; -; Genomic_DNA.
DR EMBL; AY565292; AAS74302.1; -; Genomic_DNA.
DR EMBL; AY565293; AAS74303.1; -; Genomic_DNA.
DR EMBL; AY565294; AAS74304.1; -; Genomic_DNA.
DR EMBL; AY565295; AAS74305.1; -; Genomic_DNA.
DR EMBL; AY565296; AAS74306.1; -; Genomic_DNA.
DR EMBL; AY565297; AAS74307.1; -; Genomic_DNA.
DR EMBL; AY565298; AAS74308.1; -; Genomic_DNA.
DR EMBL; AY565299; AAS74309.1; -; Genomic_DNA.
DR EMBL; AY565300; AAS74310.1; -; Genomic_DNA.
DR EMBL; AY565301; AAS74311.1; -; Genomic_DNA.
DR EMBL; AY565302; AAS74312.1; -; Genomic_DNA.
DR EMBL; AY565303; AAS74313.1; -; Genomic_DNA.
DR EMBL; AY565304; AAS74314.1; -; Genomic_DNA.
DR EMBL; AY565305; AAS74315.1; -; Genomic_DNA.
DR EMBL; AY565306; AAS74316.1; -; Genomic_DNA.
DR EMBL; AY565307; AAS74317.1; -; Genomic_DNA.
DR EMBL; AY565308; AAS74318.1; -; Genomic_DNA.
DR EMBL; AY565309; AAS74319.1; -; Genomic_DNA.
DR EMBL; AY565310; AAS74320.1; -; Genomic_DNA.
DR EMBL; AY565311; AAS74321.1; -; Genomic_DNA.
DR EMBL; AY565312; AAS74322.1; -; Genomic_DNA.
DR EMBL; AY565313; AAS74323.1; -; Genomic_DNA.
DR EMBL; AY565314; AAS74324.1; -; Genomic_DNA.
DR EMBL; AY565315; AAS74325.1; -; Genomic_DNA.
DR EMBL; AY565316; AAS74326.1; -; Genomic_DNA.
DR EMBL; AY565317; AAS74327.1; -; Genomic_DNA.
DR EMBL; AY565318; AAS74328.1; -; Genomic_DNA.
DR EMBL; AY565319; AAS74329.1; -; Genomic_DNA.
DR EMBL; AY565320; AAS74330.1; -; Genomic_DNA.
DR EMBL; AY565321; AAS74331.1; -; Genomic_DNA.
DR EMBL; AY565322; AAS74332.1; -; Genomic_DNA.
DR EMBL; AY565323; AAS74333.1; -; Genomic_DNA.
DR EMBL; AY565324; AAS74334.1; -; Genomic_DNA.
DR EMBL; AY565325; AAS74335.1; -; Genomic_DNA.
DR EMBL; AY565326; AAS74336.1; -; Genomic_DNA.
DR EMBL; AY565327; AAS74337.1; -; Genomic_DNA.
DR EMBL; AY565328; AAS74338.1; -; Genomic_DNA.
DR EMBL; AY565329; AAS74339.1; -; Genomic_DNA.
DR EMBL; AY565330; AAS74340.1; -; Genomic_DNA.
DR EMBL; AY565331; AAS74341.1; -; Genomic_DNA.
DR EMBL; AY565332; AAS74342.1; -; Genomic_DNA.
DR EMBL; AY565333; AAS74343.1; -; Genomic_DNA.
DR EMBL; AY565334; AAS74344.1; -; Genomic_DNA.
DR EMBL; AY565335; AAS74345.1; -; Genomic_DNA.
DR EMBL; AY565336; AAS74346.1; -; Genomic_DNA.
DR EMBL; AY565337; AAS74347.1; -; Genomic_DNA.
DR EMBL; AY565338; AAS74348.1; -; Genomic_DNA.
DR EMBL; AY565339; AAS74349.1; -; Genomic_DNA.
DR EMBL; AY565340; AAS74350.1; -; Genomic_DNA.
DR EMBL; AY565341; AAS74351.1; -; Genomic_DNA.
DR EMBL; AY565342; AAS74352.1; -; Genomic_DNA.
DR EMBL; AY565343; AAS74353.1; -; Genomic_DNA.
DR EMBL; AY565344; AAS74354.1; -; Genomic_DNA.
DR EMBL; AY565345; AAS74355.1; -; Genomic_DNA.
DR EMBL; AY565346; AAS74356.1; -; Genomic_DNA.
DR EMBL; AY565347; AAS74357.1; -; Genomic_DNA.
DR EMBL; AY565348; AAS74358.1; -; Genomic_DNA.
DR EMBL; AY565349; AAS74359.1; -; Genomic_DNA.
DR EMBL; AY565350; AAS74360.1; -; Genomic_DNA.
DR EMBL; AY565351; AAS74361.1; -; Genomic_DNA.
DR EMBL; AY565352; AAS74362.1; -; Genomic_DNA.
DR EMBL; AY565353; AAS74363.1; -; Genomic_DNA.
DR EMBL; AY565354; AAS74364.1; -; Genomic_DNA.
DR EMBL; AY565355; AAS74365.1; -; Genomic_DNA.
DR EMBL; AY565356; AAS74366.1; -; Genomic_DNA.
DR EMBL; AY565357; AAS74367.1; -; Genomic_DNA.
DR EMBL; AY565358; AAS74368.1; -; Genomic_DNA.
DR EMBL; AY565359; AAS74369.1; -; Genomic_DNA.
DR EMBL; AY565360; AAS74370.1; -; Genomic_DNA.
DR EMBL; AY565361; AAS74371.1; -; Genomic_DNA.
DR EMBL; AY565362; AAS74372.1; -; Genomic_DNA.
DR EMBL; AY565363; AAS74373.1; -; Genomic_DNA.
DR EMBL; AY565364; AAS74374.1; -; Genomic_DNA.
DR EMBL; AY565365; AAS74375.1; -; Genomic_DNA.
DR EMBL; AY565366; AAS74376.1; -; Genomic_DNA.
DR EMBL; AY565367; AAS74377.1; -; Genomic_DNA.
DR EMBL; AY565368; AAS74378.1; -; Genomic_DNA.
DR PIR; S19155; S19155.
DR RefSeq; NP_725849.1; NM_166322.2.
DR AlphaFoldDB; P28285; -.
DR SMR; P28285; -.
DR STRING; 7227.FBpp0085761; -.
DR GlyGen; P28285; 8 sites.
DR PaxDb; P28285; -.
DR EnsemblMetazoa; FBtr0086577; FBpp0085761; FBgn0004168.
DR GeneID; 37196; -.
DR KEGG; dme:Dmel_CG16720; -.
DR CTD; 37196; -.
DR FlyBase; FBgn0004168; 5-HT1A.
DR VEuPathDB; VectorBase:FBgn0004168; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_1_1; -.
DR InParanoid; P28285; -.
DR PhylomeDB; P28285; -.
DR Reactome; R-DME-390666; Serotonin receptors.
DR Reactome; R-DME-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 37196; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 37196; -.
DR PRO; PR:P28285; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0004168; Expressed in brain and 12 other tissues.
DR ExpressionAtlas; P28285; baseline and differential.
DR Genevisible; P28285; DM.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0008227; F:G protein-coupled amine receptor activity; ISS:FlyBase.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IDA:FlyBase.
DR GO; GO:0001586; F:Gi/o-coupled serotonin receptor activity; NAS:FlyBase.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0007198; P:adenylate cyclase-inhibiting serotonin receptor signaling pathway; IDA:FlyBase.
DR GO; GO:0007615; P:anesthesia-resistant memory; IDA:FlyBase.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase.
DR GO; GO:0008049; P:male courtship behavior; IMP:FlyBase.
DR GO; GO:0007208; P:phospholipase C-activating serotonin receptor signaling pathway; IDA:FlyBase.
DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IMP:FlyBase.
DR GO; GO:0007210; P:serotonin receptor signaling pathway; IDA:FlyBase.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..834
FT /note="5-hydroxytryptamine receptor 2A"
FT /id="PRO_0000068962"
FT TOPO_DOM 1..230
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 231..253
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 254..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 264..285
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 286..300
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 301..322
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 323..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 342..364
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 365..391
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 392..413
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 414..752
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 753..776
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 777..785
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 786..808
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 809..834
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 56..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 299..378
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 29..32
FT /note="Missing (in strain: CA-128)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 46
FT /note="E -> Q (in strain: NC-066)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 49
FT /note="E -> V (in strain: NC-036 and NC-123)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 51
FT /note="D -> E (in strain: CA-002, CA-008, CA-009, CA-011,
FT CA-013, CA-015, CA-026, CA-031, CA-033, CA-034, CA-035, CA-
FT 037, CA-040, CA-048, CA-052, CA-055, CA-057, CA-060, CA-
FT 061, CA-063, CA-064, CA-065, CA-069, CA-072, CA-073, CA-
FT 075, CA-088, CA-090, CA-093, CA-096, CA-100, CA-114, CA-
FT 120, CA-127, CA-129, CA-132, CA-133, CA-140, CA-142, CA-
FT 145, CA-147, NC-003, NC-006, NC-010, NC-011, NC-014, NC-
FT 015, NC-021, NC-033, NC-034, NC-036, NC-040, NC-042, NC-
FT 044, NC-046, NC-047, NC-051, NC-052, NC-054, NC-057, NC-
FT 066, NC-069, NC-071, NC-073, NC-081, NC-084, NC-086, NC-
FT 089, NC-092, NC-094, NC-096, NC-097, NC-101, NC-103, NC-
FT 104, NC-107, NC-108, NC-118, NC-119, NC-121, NC-123, NC-
FT 127, NC-128, NC-129, NC-134, NC-136, NC-137, NC-138, NC-
FT 141, NC-144 and NC-148)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 52
FT /note="D -> E (in strain: NC-103 and NC-118)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 54
FT /note="A -> G (in strain: NC-061)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 76
FT /note="S -> T (in strain: NC-012, NC-023, NC-037, NC-038,
FT NC-039, NC-124 and NC-131)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 86
FT /note="S -> T (in strain: CA-008, CA-009, CA-013, CA-026,
FT CA-031, CA-033, CA-035, CA-037, CA-040, CA-048, CA-052, CA-
FT 057, CA-060, CA-061, CA-063, CA-065, CA-072, CA-073, CA-
FT 088, CA-093, CA-096, CA-100, CA-114, CA-120, CA-129, CA-
FT 132, CA-133, CA-140, CA-147, NC-011, NC-015, NC-021, NC-
FT 033, NC-034, NC-040, NC-042, NC-044, NC-046, NC-047, NC-
FT 051, NC-052, NC-054, NC-057, NC-069, NC-084, NC-089, NC-
FT 092, NC-094, NC-097, NC-103, NC-107, NC-119, NC-121, NC-
FT 127, NC-128, NC-129, NC-134, NC-137, NC-138, NC-141, NC-144
FT and NC-148)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 91
FT /note="P -> Q (in strain: CA-030, CA-068, CA-091, NC-008,
FT NC-025, NC-043, NC-048, NC-060, NC-075, NC-088, NC-091, NC-
FT 114, NC-116 and NC-135)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 96
FT /note="V -> A (in strain: CA-008, CA-009, CA-011, CA-013,
FT CA-015, CA-026, CA-031, CA-033, CA-034, CA-035, CA-037, CA-
FT 040, CA-048, CA-052, CA-055, CA-057, CA-060, CA-061, CA-
FT 063, CA-064, CA-065, CA-069, CA-072, CA-073, CA-075, CA-
FT 088, CA-090, CA-093, CA-095, CA-096, CA-100, CA-114, CA-
FT 120, CA-129, CA-132, CA-133, CA-140, CA-147, NC-010, NC-
FT 011, NC-012, NC-014, NC-015, NC-021, NC-023, NC-033, NC-
FT 034, NC-036, NC-037, NC-038, NC-039, NC-040, NC-042, NC-
FT 044, NC-046, NC-047, NC-051, NC-052, NC-054, NC-057, NC-
FT 066, NC-069, NC-073, NC-081, NC-084, NC-086, NC-089, NC-
FT 092, NC-094, NC-096, NC-097, NC-101, NC-103, NC-104, NC-
FT 107, NC-108, NC-118, NC-119, NC-121, NC-123, NC-124, NC-
FT 127, NC-128, NC-129, NC-131, NC-134, NC-136, NC-137, NC-
FT 138, NC-141, NC-144, NC-148 and Oregon-R)"
FT /evidence="ECO:0000269|PubMed:1310937,
FT ECO:0000269|PubMed:15611167"
FT VARIANT 143
FT /note="A -> T (in strain: CA-064)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 146
FT /note="S -> T (in strain: CA-008, CA-026, CA-033, CA-035,
FT CA-037, CA-048, CA-052, CA-057, CA-060, CA-063, CA-065, CA-
FT 072, CA-088, CA-090, CA-096, CA-100, CA-114, CA-120, CA-
FT 132, CA-140, CA-147, NC-011, NC-014, NC-033, NC-034, NC-
FT 040, NC-042, NC-044, NC-046, NC-047, NC-051, NC-052, NC-
FT 054, NC-057, NC-069, NC-084, NC-092, NC-094, NC-096, NC-
FT 103, NC-105, NC-107, NC-108, NC-118, NC-119, NC-121, NC-
FT 125, NC-126, NC-127, NC-129, NC-138, NC-144 and NC-148)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 171
FT /note="A -> V (in strain: CA-008, CA-009, CA-026, CA-031,
FT CA-033, CA-035, CA-037, CA-048, CA-052, CA-057, CA-060, CA-
FT 061, CA-063, CA-065, CA-072, CA-088, CA-096, CA-100, CA-
FT 114, CA-120, CA-132, CA-140, CA-147, NC-011, NC-034, NC-
FT 040, NC-042, NC-044, NC-046, NC-047, NC-051, NC-052, NC-
FT 054, NC-057, NC-069, NC-084, NC-092, NC-094, NC-103, NC-
FT 107, NC-119, NC-121, NC-127, NC-129, NC-138, NC-144 and NC-
FT 148)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 182
FT /note="G -> D (in strain: NC-066)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 184
FT /note="D -> Y (in strain: NC-086, NC-104 and NC-010)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 196
FT /note="S -> N (in strain: NC-114)"
FT /evidence="ECO:0000269|PubMed:1310937,
FT ECO:0000269|PubMed:15611167"
FT VARIANT 198
FT /note="Q -> H (in strain: CA-001, CA-009, CA-011, CA-013,
FT CA-015, CA-026, CA-030, CA-031, CA-033, CA-034, CA-035, CA-
FT 037, CA-040, CA-046, CA-048, CA-052, CA-055, CA-057, CA-
FT 060, CA-061, CA-063, CA-065, CA-066, CA-068, CA-069, CA-
FT 072, CA-073, CA-075, CA-088, CA-090, CA-091, CA-093, CA-
FT 095, CA-096, CA-100, CA-114, CA-120, CA-132, CA-133, CA-
FT 140, CA-147, NC-008, NC-011, NC-014, NC-015, NC-025, NC-
FT 034, NC-040, NC-042, NC-043, NC-044, NC-046, NC-047, NC-
FT 048, NC-051, NC-052, NC-054, NC-057, NC-060, NC-066, NC-
FT 069, NC-073, NC-075, NC-081, NC-084, NC-088, NC-091, NC-
FT 092, NC-094, NC-096, NC-101, NC-103, NC-107, NC-108, NC-
FT 110, NC-113, NC-114, NC-115, NC-116, NC-118, NC-119, NC-
FT 121, NC-123, NC-127, NC-128, NC-129, NC-135, NC-136, NC-
FT 137, NC-138, NC-139, NC-142, NC-144, NC-146, NC-148 and
FT Oregon-R)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 213
FT /note="S -> G (in strain: CA-015)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 531
FT /note="Q -> L (in strain: NC-104)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 536
FT /note="T -> A (in strain: CA-011, CA-017, CA-018, CA-062,
FT CA-130, NC-118, NC-022, NC-026, NC-049 and NC-073)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 547..550
FT /note="APSG -> GPMGPL (in strain: CA-013, CA-026 and CA-
FT 093)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 571
FT /note="E -> V (in strain: CA-002, CA-003, CA-008, CA-011,
FT CA-012, CA-015, CA-023, CA-027, CA-030, CA-031, CA-034, CA-
FT 035, CA-037, CA-043, CA-044, CA-045, CA-046, CA-048, CA-
FT 052, CA-055, CA-057, CA-058, CA-063, CA-064, CA-065, CA-
FT 066, CA-068, CA-070, CA-072, CA-073, CA-075, CA-081, CA-
FT 083, CA-087, CA-088, CA-089, CA-091, CA-096, CA-100, CA-
FT 105, CA-114, CA-120, CA-123, CA-128, CA-129, CA-133, CA-
FT 140, CA-145, CA-147, CA-148, NC-001, NC-002, NC-003, NC-
FT 010, NC-011, NC-012, NC-013, NC-015, NC-023, NC-024, NC-
FT 025, NC-027, NC-028, NC-029, NC-030, NC-032, NC-033, NC-
FT 034, NC-036, NC-040, NC-041, NC-042, NC-043, NC-044, NC-
FT 046, NC-047, NC-048, NC-050, NC-051, NC-052, NC-054, NC-
FT 057, NC-059, NC-060, NC-061, NC-066, NC-069, NC-071, NC-
FT 072, NC-074, NC-075, NC-077, NC-079, NC-080, NC-081, NC-
FT 084, NC-086, NC-087, NC-088, NC-089, NC-091, NC-092, NC-
FT 094, NC-098, NC-101, NC-103, NC-104, NC-107, NC-109, NC-
FT 110, NC-111, NC-112, NC-113, NC-114, NC-115, NC-116, NC-
FT 119, NC-121, NC-124, NC-127, NC-128, NC-129, NC-131, NC-
FT 133, NC-134, NC-135, NC-136, NC-137, NC-138, NC-144, NC-
FT 146, NC-147, NC-148 and NC-149)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 585
FT /note="T -> K (in strain: NC-026)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 588
FT /note="T -> M (in strain: Berkeley, CA-009, CA-010, CA-013,
FT CA-026, CA-041, CA-060, CA-063, CA-066, CA-086, CA-093, CA-
FT 113, CA-137, CA-145, NC-006, NC-008, NC-021, NC-064, NC-
FT 067, NC-123, NC-142 and NC-150)"
FT /evidence="ECO:0000269|PubMed:10731132,
FT ECO:0000269|PubMed:15611167, ECO:0000269|Ref.4"
FT VARIANT 589
FT /note="T -> R (in strain: CA-040, CA-056, CA-115, CA-118,
FT CA-126, CA-132, CA-142, NC-005, NC-037, NC-038, NC-039, NC-
FT 053, NC-068, NC-095, NC-100, NC-105, NC-125, NC-126 and NC-
FT 139)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 648
FT /note="A -> V (in strain: CA-023, CA-048, NC-015, NC-110,
FT NC-128, NC-133 and NC-137)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 657
FT /note="Q -> P (in strain: CA-130)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 682
FT /note="S -> W (in strain: CA-043, CA-058 and CA-105)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 688
FT /note="T -> I (in strain: CA-088)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 692
FT /note="S -> T (in strain: NC-104)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 706
FT /note="P -> T (in strain: NC-001)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 716..718
FT /note="Missing (in strain: NC-118)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 716..717
FT /note="Missing (in strain: CA-002, CA-009, CA-010, CA-011,
FT CA-017, CA-018, CA-023, CA-030, CA-031, CA-037, CA-040, CA-
FT 041, CA-044, CA-045, CA-047, CA-048, CA-052, CA-056, CA-
FT 057, CA-062, CA-068, CA-070, CA-075, CA-086, CA-087, CA-
FT 088, CA-089, CA-091, CA-095, CA-096, CA-100, CA-113, CA-
FT 114, CA-115, CA-118, CA-120, CA-126, CA-127, CA-129, CA-
FT 132, CA-133, CA-136, CA-140, CA-142, CA-145, CA-147, NC-
FT 001, NC-003, NC-004, NC-005, NC-011, NC-015, NC-017, NC-
FT 021, NC-022, NC-025, NC-033, NC-034, NC-036, NC-037, NC-
FT 038, NC-039, NC-040, NC-042, NC-044, NC-046, NC-048, NC-
FT 049, NC-051, NC-052, NC-053, NC-054, NC-057, NC-059, NC-
FT 068, NC-069, NC-070, NC-071, NC-079, NC-080, NC-084, NC-
FT 086, NC-087, NC-088, NC-089, NC-091, NC-092, NC-094, NC-
FT 095, NC-100, NC-101, NC-104, NC-105, NC-107, NC-109, NC-
FT 110, NC-111, NC-112, NC-113, NC-114, NC-115, NC-116, NC-
FT 119, NC-121, NC-123, NC-125, NC-126, NC-128, NC-129, NC-
FT 133, NC-134, NC-135, NC-136, NC-137, NC-138, NC-139, NC-
FT 142, NC-144, NC-146, NC-147, NC-148, NC-149 and NC-150)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 716
FT /note="Q -> H (in strain: NC-032)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT VARIANT 716
FT /note="Q -> QH (in strain: NC-047)"
FT VARIANT 717..719
FT /note="QQQ -> H (in strain: CA-069, NC-096 and NC-108)"
FT /evidence="ECO:0000269|PubMed:15611167"
FT CONFLICT 135
FT /note="R -> W (in Ref. 1; CAA77570)"
FT /evidence="ECO:0000305"
FT CONFLICT 400
FT /note="L -> M (in Ref. 1; CAA77570)"
FT /evidence="ECO:0000305"
FT CONFLICT 813
FT /note="R -> Q (in Ref. 4; AAY84887)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 834 AA; 89521 MW; D3E27389921BD04F CRC64;
MAHETSFNDA LDYIYIANSM NDRAFLIAEP HPEQPNVDGQ DQDDAELEEL DDMAVTDDGQ
LEDTNNNNNS KRYYSSGKRR ADFIGSLALK PPPTDVNTTT TTAGSPLATA ALAAAAASAS
VAAAAARITA KAAHRALTTK QDATSSPASS PALQLIDMDN NYTNVAVGLG AMLLNDTLLL
EGNDSSLFGE MLANRSGQLD LINGTGGLNV TTSKVAEDDF TQLLRMAVTS VLLGLMILVT
IIGNVFVIAA IILERNLQNV ANYLVASLAV ADLFVACLVM PLGAVYEISQ GWILGPELCD
IWTSCDVLCC TASILHLVAI AVDRYWAVTN IDYIHSRTSN RVFMMIFCVW TAAVIVSLAP
QFGWKDPDYL QRIEQQKCMV SQDVSYQVFA TCCTFYVPLL VILALYWKIY QTARKRIHRR
RPRPVDAAVN NNQPDGGAAT DTKLHRLRLR LGRFSTAKSK TGSAVGVSGP ASGGRALGLV
DGNSTNTVNT VEDTEFSSSN VDSKSRAGVE APSTSGNQIA TVSHLVALAK QQGKSTAKSS
AAVNGMAPSG RQEDDGQRPE HGEQEDREEL EDQDEQVGPQ PTTATSATTA AGTNESEDQC
KANGVEVLED PQLQQQLEQV QQLQKSVKSG GGGGASTSNA TTITSISALS PQTPTSQGVG
IAAAAAGPMT AKTSTLTSCN QSHPLCGTAN ESPSTPEPRS RQPTTPQQQP HQQAHQQQQQ
QQQLSSIANP MQKVNKRKET LEAKRERKAA KTLAIITGAF VVCWLPFFVM ALTMPLCAAC
QISDSVASLF LWLGYFNSTL NPVIYTIFSP EFRQAFKRIL FGGHRPVHYR SGKL
