ID   LLDP_SALTY              Reviewed;         551 AA.
AC   Q8ZL63;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=L-lactate permease {ECO:0000250|UniProtKB:P33231};
GN   Name=lldP; Synonyms=lctP; OrderedLocusNames=STM3692;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Uptake of L-lactate across the membrane (By similarity). Can
CC       also transport D-lactate and glycolate (By similarity). Seems to be
CC       driven by a proton motive force (By similarity).
CC       {ECO:0000250|UniProtKB:P33231}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out);
CC         Xref=Rhea:RHEA:29415, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651;
CC         Evidence={ECO:0000250|UniProtKB:P33231};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29417;
CC         Evidence={ECO:0000250|UniProtKB:P33231};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-lactate(in) + H(+)(in) = (R)-lactate(out) + H(+)(out);
CC         Xref=Rhea:RHEA:71791, ChEBI:CHEBI:15378, ChEBI:CHEBI:16004;
CC         Evidence={ECO:0000250|UniProtKB:P33231};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71793;
CC         Evidence={ECO:0000250|UniProtKB:P33231};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycolate(in) + H(+)(in) = glycolate(out) + H(+)(out);
CC         Xref=Rhea:RHEA:29411, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805;
CC         Evidence={ECO:0000250|UniProtKB:P33231};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29413;
CC         Evidence={ECO:0000250|UniProtKB:P33231};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P33231}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the lactate permease family. {ECO:0000305}.
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DR   EMBL; AE006468; AAL22551.1; -; Genomic_DNA.
DR   RefSeq; NP_462592.1; NC_003197.2.
DR   RefSeq; WP_001055305.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZL63; -.
DR   STRING; 99287.STM3692; -.
DR   PaxDb; Q8ZL63; -.
DR   PRIDE; Q8ZL63; -.
DR   EnsemblBacteria; AAL22551; AAL22551; STM3692.
DR   GeneID; 1255216; -.
DR   KEGG; stm:STM3692; -.
DR   PATRIC; fig|99287.12.peg.3905; -.
DR   HOGENOM; CLU_021628_0_0_6; -.
DR   OMA; LFVYKMP; -.
DR   PhylomeDB; Q8ZL63; -.
DR   BioCyc; SENT99287:STM3692-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003; PTHR30003; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
DR   TIGRFAMs; TIGR00795; lctP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..551
FT                   /note="L-lactate permease"
FT                   /id="PRO_0000210378"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        530..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   551 AA;  59417 MW;  EF7314BC5FF04F88 CRC64;
     MNLWQQNYDP AGNIWLSSLI ASLPILFFFF ALIKLKLKGY VAASWTVVIA LAVALLFYKM
     PVDHALASVV YGFFYGLWPI AWIIIAAVFV YKISVKTGQF DIIRSSILSI TPDQRLQMLI
     VGFCFGAFLE GAAGFGAPVA ITAALLVGLG FNPLYAAGLC LIVNTAPVAF GAMGIPILVA
     GQVTGLDSFE IGQMVGRQLP FLTIIVLFWI MAIMDGWRGV KETWPAVMVA GGSFAIAQYL
     SSNFIGPELP DIISSLVSLV CLTLFLKRWQ PVRIFRFGDM GASQVDQTLA RTRYTTGQIV
     RAWSPFLFLT ATVTLWSVPP FKALFAPGGA LYDWVINVPV PYLDKLVARM PPVVHEATAY
     AAVYKFDWFS ATGTAILFAA LLSIVWLKMK PSAAIQTFGS TLKELALPIY SIGMVLAFAF
     ISNYSGLSST LALALAHTGS AFTFFSPFLG WLGVFLTGSD TSSNALFASL QATAAQQIGV
     SDVLMVAANT TGGVTGKMIS PQSIAIACAA VGLVGKESDL FRFTVKHSLI FTCMVGVITT
     LQAYVLTWMI P