ID   LLDR_ECOLI              Reviewed;         258 AA.
AC   P0ACL7; P33233; Q2M7R8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Putative L-lactate dehydrogenase operon regulatory protein;
GN   Name=lldR; Synonyms=lctR; OrderedLocusNames=b3604, JW3579;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=8407843; DOI=10.1128/jb.175.20.6671-6678.1993;
RA   Dong J.M., Taylor J.S., Latour D.J., Iuchi S., Lin E.C.C.;
RT   "Three overlapping lct genes involved in L-lactate utilization by
RT   Escherichia coli.";
RL   J. Bacteriol. 175:6671-6678(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA   Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT   from 76.0 to 81.5 minutes.";
RL   Nucleic Acids Res. 22:2576-2586(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: May be a regulatory protein for the LCT genes.
CC   -!- INDUCTION: By L-lactate; aerobically.
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DR   EMBL; L13970; AAA03584.1; -; Unassigned_DNA.
DR   EMBL; U00039; AAB18581.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76628.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77688.1; -; Genomic_DNA.
DR   PIR; B49904; B49904.
DR   RefSeq; NP_418061.1; NC_000913.3.
DR   RefSeq; WP_000636500.1; NZ_STEB01000024.1.
DR   AlphaFoldDB; P0ACL7; -.
DR   SMR; P0ACL7; -.
DR   BioGRID; 4260906; 7.
DR   DIP; DIP-10110N; -.
DR   IntAct; P0ACL7; 5.
DR   STRING; 511145.b3604; -.
DR   PaxDb; P0ACL7; -.
DR   PRIDE; P0ACL7; -.
DR   EnsemblBacteria; AAC76628; AAC76628; b3604.
DR   EnsemblBacteria; BAE77688; BAE77688; BAE77688.
DR   GeneID; 58389546; -.
DR   GeneID; 948122; -.
DR   KEGG; ecj:JW3579; -.
DR   KEGG; eco:b3604; -.
DR   PATRIC; fig|1411691.4.peg.3102; -.
DR   EchoBASE; EB1905; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_5_6; -.
DR   InParanoid; P0ACL7; -.
DR   OMA; SFVVDFH; -.
DR   PhylomeDB; P0ACL7; -.
DR   BioCyc; EcoCyc:EG11962-MON; -.
DR   PRO; PR:P0ACL7; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:EcoCyc.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IMP:EcoCyc.
DR   GO; GO:0001217; F:DNA-binding transcription repressor activity; IMP:EcoCyc.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR   GO; GO:2000143; P:negative regulation of DNA-templated transcription, initiation; IMP:EcoCyc.
DR   GO; GO:2000144; P:positive regulation of DNA-templated transcription, initiation; IMP:EcoCyc.
DR   GO; GO:0044010; P:single-species biofilm formation; IMP:EcoCyc.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..258
FT                   /note="Putative L-lactate dehydrogenase operon regulatory
FT                   protein"
FT                   /id="PRO_0000050652"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   258 AA;  29166 MW;  59C4643B3456079E CRC64;
     MIVLPRRLSD EVADRVRALI DEKNLEAGMK LPAERQLAMQ LGVSRNSLRE ALAKLVSEGV
     LLSRRGGGTF IRWRHDTWSE QNIVQPLKTL MADDPDYSFD ILEARYAIEA STAWHAAMRA
     TPGDKEKIQL CFEATLSEDP DIASQADVRF HLAIAEASHN IVLLQTMRGF FDVLQSSVKH
     SRQRMYLVPP VFSQLTEQHQ AVIDAIFAGD ADGARKAMMA HLSFVHTTMK RFDEDQARHA
     RITRLPGEHN EHSREKNA