ID   LLDR_SHIFL              Reviewed;         258 AA.
AC   P0ACL8; P33233;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Putative L-lactate dehydrogenase operon regulatory protein;
GN   Name=lldR; Synonyms=lctR; OrderedLocusNames=SF3643, S4125;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: May be a regulatory protein for the LCT genes. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005674; AAN45090.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP19102.1; -; Genomic_DNA.
DR   RefSeq; NP_709383.2; NC_004337.2.
DR   RefSeq; WP_000636500.1; NZ_WPGW01000082.1.
DR   AlphaFoldDB; P0ACL8; -.
DR   SMR; P0ACL8; -.
DR   STRING; 198214.SF3643; -.
DR   PRIDE; P0ACL8; -.
DR   EnsemblBacteria; AAN45090; AAN45090; SF3643.
DR   EnsemblBacteria; AAP19102; AAP19102; S4125.
DR   GeneID; 1026271; -.
DR   GeneID; 58389546; -.
DR   KEGG; sfl:SF3643; -.
DR   KEGG; sfx:S4125; -.
DR   PATRIC; fig|198214.7.peg.4302; -.
DR   HOGENOM; CLU_017584_9_5_6; -.
DR   OrthoDB; 1875458at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..258
FT                   /note="Putative L-lactate dehydrogenase operon regulatory
FT                   protein"
FT                   /id="PRO_0000050653"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   258 AA;  29166 MW;  59C4643B3456079E CRC64;
     MIVLPRRLSD EVADRVRALI DEKNLEAGMK LPAERQLAMQ LGVSRNSLRE ALAKLVSEGV
     LLSRRGGGTF IRWRHDTWSE QNIVQPLKTL MADDPDYSFD ILEARYAIEA STAWHAAMRA
     TPGDKEKIQL CFEATLSEDP DIASQADVRF HLAIAEASHN IVLLQTMRGF FDVLQSSVKH
     SRQRMYLVPP VFSQLTEQHQ AVIDAIFAGD ADGARKAMMA HLSFVHTTMK RFDEDQARHA
     RITRLPGEHN EHSREKNA