ID   LLPA_NOTEU              Reviewed;         176 AA.
AC   P20462;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Late lactation protein A;
DE            Short=LLP-A;
DE   Flags: Precursor;
GN   Name=LLPA;
OS   Notamacropus eugenii (Tammar wallaby) (Macropus eugenii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Notamacropus.
OX   NCBI_TaxID=9315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2590207; DOI=10.1016/0006-291x(89)91822-6;
RA   Collet C., Joseph R., Nicholas K.R.;
RT   "Molecular cloning and characterization of a novel marsupial milk protein
RT   gene.";
RL   Biochem. Biophys. Res. Commun. 164:1380-1383(1989).
RN   [2]
RP   PROTEIN SEQUENCE OF 19-87 AND 116-131.
RX   PubMed=3109381; DOI=10.1042/bj2410899;
RA   Nicholas K.R., Messer M., Elliot C., Maher F., Shaw D.C.;
RT   "A novel whey protein synthesized only in late lactation by the mammary
RT   gland from the tammar (Macropus eugenii).";
RL   Biochem. J. 241:899-904(1987).
RN   [3]
RP   SIMILARITY TO THE LIPOCALIN FAMILY.
RX   PubMed=8466952; DOI=10.1016/0005-2760(93)90165-6;
RA   Collet C., Joseph R.;
RT   "A novel member of the lipocalin superfamily: tammar wallaby late-lactation
RT   protein.";
RL   Biochim. Biophys. Acta 1167:219-222(1993).
CC   -!- FUNCTION: Probably serves a role in the transport of a small ligand
CC       released during the hydrolysis of milk fat.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- DEVELOPMENTAL STAGE: Produced during the late phase of lactation.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; X15213; CAA33283.1; -; mRNA.
DR   PIR; A28561; A28561.
DR   PIR; A33672; A33672.
DR   AlphaFoldDB; P20462; -.
DR   SMR; P20462; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002450; von_Ebner_gland.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01175; VNEBNERGLAND.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Milk protein; Secreted; Signal;
KW   Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:3109381"
FT   CHAIN           19..176
FT                   /note="Late lactation protein A"
FT                   /id="PRO_0000017985"
FT   DISULFID        78..171
FT                   /evidence="ECO:0000250"
FT   CONFLICT        59
FT                   /note="T -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        126
FT                   /note="T -> I (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   176 AA;  20612 MW;  B327EA4F09DED435 CRC64;
     MRVLFLTISL SLFSIIHADD FAFSEFKPSE GTYYVQVIAV DKEFPEDEIP RDISPLTITY
     LNNGKMEAKF TVKKDNNCEE INLTLEKIDE PRKITTTRHL HHICDTVRTS EEKYWILSCV
     REFQGTQIRE AELVGPNTDE NPKALEDFYR FINRERFVER RIITPRQTEA CTSENA