LLPH_BOVIN
ID LLPH_BOVIN Reviewed; 127 AA.
AC Q2TBR9;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Protein LLP homolog;
DE AltName: Full=Protein LAPS18-like;
GN Name=LLPH;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In hippocampal neurons, regulates dendritic and spine growth
CC and synaptic transmission. {ECO:0000250|UniProtKB:Q9D945}.
CC -!- SUBUNIT: Interacts with CTCF, MYO1C and with the transcriptional
CC machinery, including RNA polymerase II and TBP.
CC {ECO:0000250|UniProtKB:Q9D945}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9D945}. Chromosome
CC {ECO:0000250|UniProtKB:Q9BRT6}. Note=Cell-permeable protein. 22 hours
CC after injection in the hippocampal area CA1, internalized by most cells
CC at the injection site (By similarity). Localizes at the chromosome
CC periphery during mitosis (By similarity).
CC {ECO:0000250|UniProtKB:Q9BRT6, ECO:0000250|UniProtKB:Q9D945}.
CC -!- SIMILARITY: Belongs to the learning-associated protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC109741; AAI09742.1; -; mRNA.
DR RefSeq; NP_001033611.1; NM_001038522.1.
DR RefSeq; XP_005206609.1; XM_005206552.3.
DR AlphaFoldDB; Q2TBR9; -.
DR SMR; Q2TBR9; -.
DR STRING; 9913.ENSBTAP00000002597; -.
DR PaxDb; Q2TBR9; -.
DR PRIDE; Q2TBR9; -.
DR Ensembl; ENSBTAT00000002597; ENSBTAP00000002597; ENSBTAG00000002004.
DR GeneID; 510518; -.
DR KEGG; bta:510518; -.
DR CTD; 84298; -.
DR VEuPathDB; HostDB:ENSBTAG00000002004; -.
DR VGNC; VGNC:30917; LLPH.
DR eggNOG; KOG4811; Eukaryota.
DR GeneTree; ENSGT00390000012979; -.
DR HOGENOM; CLU_134502_0_0_1; -.
DR InParanoid; Q2TBR9; -.
DR OMA; PVWMNPR; -.
DR OrthoDB; 1594400at2759; -.
DR TreeFam; TF314654; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000002004; Expressed in oocyte and 108 other tissues.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0001099; F:basal RNA polymerase II transcription machinery binding; IBA:GO_Central.
DR GO; GO:0097484; P:dendrite extension; IBA:GO_Central.
DR InterPro; IPR018784; LAPS18-like.
DR PANTHER; PTHR34253; PTHR34253; 1.
DR Pfam; PF10169; Laps; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation.
FT CHAIN 1..127
FT /note="Protein LLP homolog"
FT /id="PRO_0000274345"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..118
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 65
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9BRT6"
FT CROSSLNK 72
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9BRT6"
SQ SEQUENCE 127 AA; 15047 MW; C5A09F0A7EF76E7A CRC64;
MAKSLRSKWK RKMRAEKRKK NAPKELSRLK SILKIDGDVL MKDVQEIATV VEPKHCQEKT
QCVVKDETDD MKMETDIKRN KKTLLDQHGQ YPIWMNQRQR KRLKAKRERK KGKSKVKAMK
AAKGLTW
