LLPH_DANRE
ID LLPH_DANRE Reviewed; 126 AA.
AC Q3B748;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Protein LLP homolog;
DE AltName: Full=Protein LAPS18-like;
GN Name=llph; ORFNames=si:dkey-9a20.7, zgc:123180;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB; TISSUE=Liver;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates dendritic and spine growth and synaptic
CC transmission. {ECO:0000250|UniProtKB:Q9D945}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9D945}. Chromosome
CC {ECO:0000250|UniProtKB:Q9BRT6}. Note=Cell-permeable protein (By
CC similarity). Localizes at the chromosome periphery during mitosis (By
CC similarity). {ECO:0000250|UniProtKB:Q9BRT6,
CC ECO:0000250|UniProtKB:Q9D945}.
CC -!- SIMILARITY: Belongs to the learning-associated protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX537162; CAK11290.1; -; Genomic_DNA.
DR EMBL; BC107822; AAI07823.1; -; mRNA.
DR RefSeq; NP_001032184.1; NM_001037107.1.
DR RefSeq; NP_001096610.1; NM_001103140.1.
DR AlphaFoldDB; Q3B748; -.
DR SMR; Q3B748; -.
DR STRING; 7955.ENSDARP00000072173; -.
DR PaxDb; Q3B748; -.
DR Ensembl; ENSDART00000077707; ENSDARP00000072173; ENSDARG00000055360.
DR GeneID; 100003313; -.
DR KEGG; dre:100003313; -.
DR CTD; 84298; -.
DR ZFIN; ZDB-GENE-051030-30; llph.
DR eggNOG; KOG4811; Eukaryota.
DR GeneTree; ENSGT00940000165344; -.
DR HOGENOM; CLU_134502_0_0_1; -.
DR InParanoid; Q3B748; -.
DR OMA; PVWMNPR; -.
DR OrthoDB; 1594400at2759; -.
DR PhylomeDB; Q3B748; -.
DR TreeFam; TF314654; -.
DR PRO; PR:Q3B748; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000055360; Expressed in gastrula and 34 other tissues.
DR ExpressionAtlas; Q3B748; baseline and differential.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0001099; F:basal RNA polymerase II transcription machinery binding; ISS:UniProtKB.
DR GO; GO:0097484; P:dendrite extension; ISS:UniProtKB.
DR GO; GO:0060999; P:positive regulation of dendritic spine development; ISS:UniProtKB.
DR InterPro; IPR018784; LAPS18-like.
DR PANTHER; PTHR34253; PTHR34253; 1.
DR Pfam; PF10169; Laps; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Nucleus; Reference proteome.
FT CHAIN 1..126
FT /note="Protein LLP homolog"
FT /id="PRO_0000274349"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..126
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 126 AA; 14491 MW; 9DB47FA096C39619 CRC64;
MAKSLRSKWR RKMRAEKRKK VAPKELARLK SALGQGEKGE ISMKDVAEIA TVVPPEKVKQ
KPADVDMQEE EADGGKMDLD TKRNKKTMLD EHGRYPVWMN QRQAKKLKAK RVGKNGKPKP
KKRLAW
