ID   LLP_BPT5                Reviewed;          77 AA.
AC   Q38162; Q66LQ9;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Lytic conversion lipoprotein {ECO:0000312|EMBL:AAU05293.1};
DE   Flags: Precursor;
GN   Name=llp;
GN   ORFNames=T5.158 {ECO:0000312|EMBL:AAS77197.1},
GN   T5p154 {ECO:0000312|EMBL:AAU05293.1};
OS   Escherichia phage T5 (Enterobacteria phage T5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus.
OX   NCBI_TaxID=2695836;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DIACYLGLYCEROL AT CYS-16, FUNCTION,
RP   INDUCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=8057856; DOI=10.1111/j.1365-2958.1994.tb01020.x;
RA   Decker K., Krauel V., Meesmann A., Heller K.J.;
RT   "Lytic conversion of Escherichia coli by bacteriophage T5: blocking of the
RT   FhuA receptor protein by a lipoprotein expressed early during infection.";
RL   Mol. Microbiol. 12:321-332(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Ksenzenko V.N., Kaliman A.V., Krutilina A.I., Shlyapnikov M.G.;
RT   "Bacteriophage T5 complete genome.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND INDUCTION.
RC   STRAIN=ATCC 11303-B5 {ECO:0000312|EMBL:AAX12084.1};
RX   PubMed=15661140; DOI=10.1016/j.virol.2004.10.049;
RA   Wang J., Jiang Y., Vincent M., Sun Y., Yu H., Wang J., Bao Q., Kong H.,
RA   Hu S.;
RT   "Complete genome sequence of bacteriophage T5.";
RL   Virology 332:45-65(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=St0 deletion mutant;
RX   PubMed=24198424; DOI=10.1128/jvi.02262-13;
RA   Zivanovic Y., Confalonieri F., Ponchon L., Lurz R., Chami M., Flayhan A.,
RA   Renouard M., Huet A., Decottignies P., Davidson A.R., Breyton C.,
RA   Boulanger P.;
RT   "Insights into bacteriophage T5 structure from analysis of its
RT   morphogenesis genes and protein components.";
RL   J. Virol. 88:1162-1174(2014).
RN   [5]
RP   FUNCTION.
RX   PubMed=8045901; DOI=10.1128/jb.176.15.4710-4717.1994;
RA   Braun V., Killmann H., Herrmann C.;
RT   "Inactivation of FhuA at the cell surface of Escherichia coli K-12 by a
RT   phage T5 lipoprotein at the periplasmic face of the outer membrane.";
RL   J. Bacteriol. 176:4710-4717(1994).
CC   -!- FUNCTION: Inhibits of the adsorption of T5 to its FhuA receptor. By
CC       this means, T5 within cells excludes superinfection by T5 and other
CC       phages using FhuA receptor as a ligand. {ECO:0000269|PubMed:8045901,
CC       ECO:0000269|PubMed:8057856}.
CC   -!- SUBCELLULAR LOCATION: Host cell outer membrane
CC       {ECO:0000269|PubMed:8057856}; Lipid-anchor {ECO:0000305}. Note=Attached
CC       to the host membrane by a lipid anchor. {ECO:0000305}.
CC   -!- INDUCTION: Expressed early during infection.
CC       {ECO:0000269|PubMed:8057856, ECO:0000305|PubMed:15661140}.
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DR   EMBL; X75922; CAA53520.1; -; Genomic_DNA.
DR   EMBL; AY543070; AAS77197.1; -; Genomic_DNA.
DR   EMBL; AY692264; AAU05293.1; -; Genomic_DNA.
DR   EMBL; AY587007; AAX12084.1; -; Genomic_DNA.
DR   PIR; S46547; S46547.
DR   RefSeq; YP_006986.1; NC_005859.1.
DR   GeneID; 2777682; -.
DR   KEGG; vg:2777682; -.
DR   Proteomes; UP000002107; Genome.
DR   Proteomes; UP000002141; Genome.
DR   Proteomes; UP000002503; Genome.
DR   GO; GO:0036406; C:anchored component of periplasmic side of cell outer membrane; IDA:CACAO.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1902735; P:negative regulation of receptor-mediated virion attachment to host cell; IMP:CACAO.
DR   GO; GO:0098669; P:superinfection exclusion; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Early protein; Host cell outer membrane; Host membrane;
KW   Host-virus interaction; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal; Superinfection exclusion.
FT   SIGNAL          1..15
FT   CHAIN           16..77
FT                   /note="Lytic conversion lipoprotein"
FT                   /id="PRO_0000003347"
FT   LIPID           16
FT                   /note="N-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000305"
FT   LIPID           16
FT                   /note="S-diacylglycerol cysteine; by host"
FT                   /evidence="ECO:0000269|PubMed:8057856"
SQ   SEQUENCE   77 AA;  8709 MW;  CA081269DA924873 CRC64;
     MKKLFLAMAV VLLSACSTFG PKDIKCEAYY MQDHVKYKAN VFDRKGDMFL VSPIMAYGSF
     WAPVSYFTEG NTCEGVF