LMA1L_MOUSE
ID LMA1L_MOUSE Reviewed; 505 AA.
AC Q8VCD3; Q4H2F4;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein ERGIC-53-like;
DE AltName: Full=ERGIC53-like protein;
DE AltName: Full=Lectin mannose-binding 1-like;
DE Short=LMAN1-like protein;
DE AltName: Full=Sublingual acinar membrane protein;
DE Short=Slamp;
DE Flags: Precursor;
GN Name=Lman1l; Synonyms=Ergl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=15923361; DOI=10.1369/jhc.5a6618.2005;
RA Sakulsak N., Wakayama T., Hipkaeo W., Yamamoto M., Iseki S.;
RT "Cloning and characterization of a novel animal lectin expressed in the rat
RT sublingual gland.";
RL J. Histochem. Cytochem. 53:1335-1343(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000250}; Single-pass type I membrane protein
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8VCD3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VCD3-2; Sequence=VSP_039811, VSP_039812;
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DR EMBL; AB211986; BAE16262.1; -; mRNA.
DR EMBL; CH466522; EDL25917.1; -; Genomic_DNA.
DR EMBL; BC020188; AAH20188.1; -; mRNA.
DR CCDS; CCDS52810.1; -. [Q8VCD3-1]
DR RefSeq; NP_954692.2; NM_199222.3. [Q8VCD3-1]
DR AlphaFoldDB; Q8VCD3; -.
DR SMR; Q8VCD3; -.
DR BioGRID; 231657; 7.
DR STRING; 10090.ENSMUSP00000091352; -.
DR GlyGen; Q8VCD3; 1 site.
DR PhosphoSitePlus; Q8VCD3; -.
DR MaxQB; Q8VCD3; -.
DR PaxDb; Q8VCD3; -.
DR PRIDE; Q8VCD3; -.
DR ProteomicsDB; 292267; -. [Q8VCD3-1]
DR ProteomicsDB; 292268; -. [Q8VCD3-2]
DR Antibodypedia; 55435; 106 antibodies from 17 providers.
DR DNASU; 235416; -.
DR Ensembl; ENSMUST00000044937; ENSMUSP00000041631; ENSMUSG00000056271. [Q8VCD3-2]
DR Ensembl; ENSMUST00000093832; ENSMUSP00000091352; ENSMUSG00000056271. [Q8VCD3-1]
DR GeneID; 235416; -.
DR KEGG; mmu:235416; -.
DR UCSC; uc009pvi.2; mouse. [Q8VCD3-1]
DR CTD; 79748; -.
DR MGI; MGI:2667537; Lman1l.
DR VEuPathDB; HostDB:ENSMUSG00000056271; -.
DR eggNOG; KOG3838; Eukaryota.
DR GeneTree; ENSGT00940000161890; -.
DR HOGENOM; CLU_041093_4_1_1; -.
DR InParanoid; Q8VCD3; -.
DR OMA; MAMWYTQ; -.
DR OrthoDB; 1377709at2759; -.
DR PhylomeDB; Q8VCD3; -.
DR TreeFam; TF313311; -.
DR Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR Reactome; R-MMU-5694530; Cargo concentration in the ER.
DR BioGRID-ORCS; 235416; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Lman1l; mouse.
DR PRO; PR:Q8VCD3; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8VCD3; protein.
DR Bgee; ENSMUSG00000056271; Expressed in submandibular gland and 12 other tissues.
DR Genevisible; Q8VCD3; MM.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005537; F:mannose binding; IBA:GO_Central.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR005052; Lectin_leg.
DR Pfam; PF03388; Lectin_leg-like; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS51328; L_LECTIN_LIKE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Lectin; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..505
FT /note="Protein ERGIC-53-like"
FT /id="PRO_0000017664"
FT TOPO_DOM 26..438
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 460..505
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..254
FT /note="L-type lectin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00658"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 177..216
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00658"
FT VAR_SEQ 356..374
FT /note="NTAKVSTLLYGQRTLIQAL -> GSSCPDGFRSTRLLPACGH (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039811"
FT VAR_SEQ 375..505
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039812"
SQ SEQUENCE 505 AA; 56312 MW; F56B1A83DCBCA16F CRC64;
MLEIRGLSPS LCLLSLLLVL HGAERSQPPP RRRFEYKLSF KGPRLAVPGA GIPFWSHHGD
AILGLEEVRL VPSMKNRSGA VWSNISVSFP SWEVEMQMRV TGPGRRGAQG VAMWYTKDRA
QVGSVVEELA SWDGIGIYFD SSTSDVQDSP VIRVLASDGH DLQEQSGDGN VRELGSCHRD
FRNRPFPFRA RVTYWRQRLR VSLSGGLTPK DPEEVCVDVE PLFLAPGGFF GVSAATGTLA
ADDHDVLSFL TFSLREPGPE ETPQPFMEKD QLLLARKLEE LKARLALGTR EASIPPLNPK
AQEEGERFFN LEDTLGRQSQ ILQALQALSR QMAQAEKHWK QQLGSTVQVR PEGGWNTAKV
STLLYGQRTL IQALQEMREA AARMASGAHV FYLPVGTKHH FFELDHILSL LQKDLRGLVK
KTAKAPRPSG WLLGSSTCLH TSIFLFFLLL QTVGFFCYVN FSRQELDKRL QEYLSTGSLS
LEPALPITRT IGVLRRQPIS PSMQA
