ID   LMBD1_ASPCL             Reviewed;         564 AA.
AC   A1C3U0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=ACLA_057360;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DS026990; EAW15080.1; -; Genomic_DNA.
DR   RefSeq; XP_001276506.1; XM_001276505.1.
DR   AlphaFoldDB; A1C3U0; -.
DR   SMR; A1C3U0; -.
DR   STRING; 5057.CADACLAP00005440; -.
DR   EnsemblFungi; EAW15080; EAW15080; ACLA_057360.
DR   GeneID; 4708923; -.
DR   KEGG; act:ACLA_057360; -.
DR   VEuPathDB; FungiDB:ACLA_057360; -.
DR   eggNOG; ENOG502QQ2T; Eukaryota.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   OMA; IITTFTW; -.
DR   OrthoDB; 744771at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..564
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365822"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   564 AA;  63083 MW;  172C95567D71702A CRC64;
     MESLQIYLIW SVYGVAIAIL IAVASTFICA YQTPRDRSPS VTLICIISIT VLLATVLLLP
     VDIALVSSIT SSALGRRKSW ATQAEVDKIT FSLTIVYYSL YTVDALLCLI GIPFTYFWYE
     EYDEVAAEAG QQTAGQRFWA AFKYTLFFVA ILIVLFLVGF FIPTSRNLAG HDSDFLRRLF
     TEDRGQHALT FSVGILTTLG LSLYIIYTSS GLARLPVLLM KTAPSFSSPS LIASTAMQLD
     SNRERQRQLD GRCGGDTALL SSKDRRELDS LVREERTLTR RQRLAEGAQE ERRSWPIKVY
     HKMEAVLHPF KLLAGFVLLL AALFLWTSLC VTAIDKLMNS PCKHRCGYIL ERVNIFNPVN
     WVLIQSSRVF PVDYVIFTLI VLFLFCSSVV GIAAFGIRFL WIQIFSIRKG RTSPQALLLL
     TSMLMLITLA LNYSVAVILA PQYATFGPQT FCDMPPVSSG PQPDCSRARN LIKSCSEKAE
     NIGANGLCTP SVASTLLNQM TSNFPFFGAV FFWAQFIFLG LYLLVLVVSV TRSPRLDEHQ
     LDEDAEEAEE ERLLARTGRR INTA