ID   LMBD1_ASPNC             Reviewed;         576 AA.
AC   A2R920;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=An16g09150;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AM270382; CAK47111.1; -; Genomic_DNA.
DR   RefSeq; XP_001398212.1; XM_001398175.2.
DR   AlphaFoldDB; A2R920; -.
DR   SMR; A2R920; -.
DR   PaxDb; A2R920; -.
DR   EnsemblFungi; CAK47111; CAK47111; An16g09150.
DR   GeneID; 4989305; -.
DR   KEGG; ang:ANI_1_1234144; -.
DR   VEuPathDB; FungiDB:An16g09150; -.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   Proteomes; UP000006706; Chromosome 5R.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..576
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365825"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          549..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..576
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        570
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   576 AA;  64668 MW;  DEED6C3AFDB2748B CRC64;
     MALLQTSLIW AVYAIVVAVL VMVASVFIYT YQTPRDRSSV VTFTCIVAIT SLLATVLLLP
     VDVALTSSTT SSKLGQRKPW ATQDEVDKIV SLLTAVYYLL YSLDAFLCLL AIPFVYFWYE
     EYDEVAVESG EQSAAKRLWT AFKYTISFIA IVVVLFIVGF LVPVANIKDS KVSDYLRKLL
     AENRGERVLT FTLGLLITMG LFLYILYTST GLAVLPMRMI RAAPSVSDMT WKASTSAQLE
     SNRERQRQLE GRCRGDPGLL SSKERRELDT LVRDERTLIR RQRLAEEADG EGQSRFMRAW
     LKTTAFFRPL KLLGGIAILL ITLMIWISML LTAIDKAKNS ICKQRCGYIL SGIGVFNPIN
     WIFVQSAKVF PIDYAVLTVV VLLLFGSSVV GISTIGIRFL WIRIFHVRKG HTSPQALLLT
     TAMLMLTILA LDYSIPMLVA PQYATFGPQT FCDRPQGQQS DCLTNKHLIK PCSELTDNTA
     AKRVCTPSVT SMFLNRVTIS YPFFGTVFFW SQFIFLVIYL LVLVTSFIRH PKLDERLLDQ
     EAEEAEEERL LTSSARGVGD TYQSVGGRNN FSTRAG