ID   LMBD1_ASPOR             Reviewed;         583 AA.
AC   Q2TZ20;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=AO090103000016;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AP007174; BAE65503.1; -; Genomic_DNA.
DR   RefSeq; XP_001826636.1; XM_001826584.2.
DR   AlphaFoldDB; Q2TZ20; -.
DR   STRING; 510516.Q2TZ20; -.
DR   EnsemblFungi; BAE65503; BAE65503; AO090103000016.
DR   GeneID; 5998758; -.
DR   KEGG; aor:AO090103000016; -.
DR   VEuPathDB; FungiDB:AO090103000016; -.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   OMA; IITTFTW; -.
DR   Proteomes; UP000006564; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..583
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365826"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          541..562
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   583 AA;  65759 MW;  615A8BB671062861 CRC64;
     MALLQTSLIW AVYAIVVAIL AAVASVFIYT YQTPRDRCPS VILTCIVAVT TLLATVLLVP
     VDVALVSSTI NPALGRRQDW ATQSEVDRIL LCLKIVYYFL YSLDALLCLI VIPFIYFLYE
     EYDEVASETE QQSFGQRFWA AFKYTVSFLA IVVVLFLVGF FVPVAKDGDG GGLDYFKHLL
     TENRGERALT FALGLLITIG LCLYVLYTST GLALFPITLI KEGPSVISPT LKATTAVQLC
     SNRERQRQLE GRCRGNPGLL SSKDRRELDT LVREERTLIR RQRLADEAHG KHQNWLMQLW
     LKFGAIFRPF QLLSGVIFSL LALIIWISML LTTIDKAKNS FCKQRCGYIL GHINVFNPIN
     WVFVQSAKIF PVDYVIFTLL VLFLFSSSIV GISAVGIRFL WIRIFQIRKG HTSPQALLLA
     TAMLMLIILA LNYSTSMILA PQYATYGPQT FCDRELSFSE KQPDCSRDKH LIRPCSEVAD
     SLAAKQVCTP SVVSTFLNRV TMNFPFFGAI FFWAQFAFLG IYLLVMVTAL LHSPKLDERQ
     LDEDAEEAEE ESLLANTRGR AETTWEDITS RLRRQNEVDR AGA