ID   LMBD1_ASPTN             Reviewed;         578 AA.
AC   Q0D219;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=ATEG_00015;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CH476594; EAU38661.1; -; Genomic_DNA.
DR   RefSeq; XP_001210101.1; XM_001210101.1.
DR   AlphaFoldDB; Q0D219; -.
DR   SMR; Q0D219; -.
DR   STRING; 341663.Q0D219; -.
DR   EnsemblFungi; EAU38661; EAU38661; ATEG_00015.
DR   GeneID; 4354771; -.
DR   VEuPathDB; FungiDB:ATEG_00015; -.
DR   eggNOG; ENOG502QQ2T; Eukaryota.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   OMA; IITTFTW; -.
DR   OrthoDB; 744771at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..578
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365827"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          539..578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        168
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   578 AA;  64777 MW;  D755C66000F76BE4 CRC64;
     MALLQTSLIW VVYAIAIAVL IAVASVFIYV YQTPRDRSPS VTLTCIFAIT TLLATVLLLP
     VDVALVSSTN SSALGRRKDW ATDHEVNKIL FSLKVVYYLL YSLDALLCLL VIPFTYFWYE
     EYDEVAAEEG EQTTGNRFWA AFKYTITFIA IVIVLFLVGF FVPVAKDNHS GGLDYFKKLL
     TENRGERALT FALGLLITIG LCLYVLYTST GLALLPVSLI KTAPSISAPN LKATTAMQLD
     SNRERQRQLE GRCGGNTELL SSKDRRELDM LVREERTLIR RQRLADEAQG EGRSWLMRAW
     LKTEAVFRPF KLLGGIILLI IALVIWVSML LTAIDKATNS FCKYHCGYIL GHITVFNPIN
     WVFVQAAKVF PVDYVIFTLL VLLFFCSSVV GIAIVGIRFL WIRIFQIRKG HTSPQALLLT
     TAMLMLTILA LNYSVSMVVA PQYATFGPQT FCDRTTGTFG EQADCSNARH LIKPCSEMIK
     NPAASGVCTP SIASTFLNRV TINFPFFGVI FFWGQFVFLG VYLIVVVASL FRSPKLDERQ
     MDEDAEEAEE EGLLASTGRR LDTAWQDITG RSNRQRDS