ID   LMBD1_CHAGB             Reviewed;         646 AA.
AC   Q2HDJ0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=CHGG_01714;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CH408029; EAQ93479.1; -; Genomic_DNA.
DR   RefSeq; XP_001220935.1; XM_001220934.1.
DR   AlphaFoldDB; Q2HDJ0; -.
DR   STRING; 306901.Q2HDJ0; -.
DR   TCDB; 9.A.54.1.2; the lysosomal cobalamin (b12) transporter (l-b12t) family.
DR   EnsemblFungi; EAQ93479; EAQ93479; CHGG_01714.
DR   GeneID; 4386940; -.
DR   eggNOG; ENOG502QQ2T; Eukaryota.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   InParanoid; Q2HDJ0; -.
DR   OMA; LINESHG; -.
DR   OrthoDB; 744771at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..646
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365829"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          459..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        513..544
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        297
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        545
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        626
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   646 AA;  70835 MW;  2594B97FA4B0F38A CRC64;
     MAPAGLLQTS LIWVAYGVAV ALVLLVSVIT TLTWQTPHER SIAVSIVSII SLTALLATVF
     LLPVDIALVS STASAHLGAK KDWATPGRVD GILLTLKIVY YTLYTLDALL CLIVIPFTYF
     WFEEYDEVEE EEGTSSAAAR IWRALKYTLG FVFLVVILFL IGFFVPAAGN NPGKHMDLDY
     FKRLLAANNG EKALTFGVGL LITLGTLLYI LYTSAGLALL PVSFIKSAPS ISAPQLSATT
     ASALEHNREL QRQLEMRNSG RPEGMSQKDR REMDALLREE RTLVRRERLA AEARGDNRSK
     IYRAWTKVEA VFRPLKLLGG IFLLLLAILI WVSMLITGID KAANSICKQH CGYILGHLNV
     FQPINWIFVQ SAKAFPVDYI LMALLVLLFF SSSITGLATI GIRFLWVRIF QLKKGRTAPQ
     ALLIATVLLG PHDPRHQLRG RHARGAAVRH LRHADLLRQP AAATRASSPT AASTATWCAP
     APRPSASPAA IGRLHADRHV HLPQPRPPSN WPRLRRPSTS GPSSSSSPSS SSSSSPASSR
     TPRLNLSELD EEAEVDERGG PAGPAPAAAL ARPGAISPAA PRRTPPRRAR RVMARRLGTR
     MGVGRARGVK LNGGAATEND KKEKKNGTWV WAWVWEWEWQ TDWLAE