ID   LMBD1_COCIM             Reviewed;         584 AA.
AC   Q1E5A9; J3KLB1;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=CIMG_02254;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG704911; EAS36900.3; -; Genomic_DNA.
DR   RefSeq; XP_001248483.1; XM_001248482.2.
DR   AlphaFoldDB; Q1E5A9; -.
DR   SMR; Q1E5A9; -.
DR   STRING; 246410.Q1E5A9; -.
DR   EnsemblFungi; EAS36900; EAS36900; CIMG_02254.
DR   GeneID; 4568109; -.
DR   KEGG; cim:CIMG_02254; -.
DR   VEuPathDB; FungiDB:CIMG_02254; -.
DR   InParanoid; Q1E5A9; -.
DR   OMA; IITTFTW; -.
DR   OrthoDB; 744771at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..584
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365830"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        509..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   584 AA;  66039 MW;  E94E0F11FD941B18 CRC64;
     MALLHSTLIW IVYAIVVGIL SIVASTFVYI YQTPRDRSAA VTTVCIFTLT ALLATVLLLP
     VDVALVSSTT SEFGRRKDWA TDHEVEKITY SLTVVYYFLY SLDAVLCLLI VPFTYFWYEE
     YDEVAYEDDG RFTRKPFWGA FKYTLVFILL TIILFLVGFF VPVAKDRKGA HFDLDYFKRL
     LTENHGERAL TFALGLLIVM GIIVYVIYSS TGLAFFPISF IKSSPSISSP MLSANIESRL
     EENIERQRQL EGRCGGNPDH LSSKDRRELD SLVREERTLR RRKRLAEASR GQGRNFVIKV
     WYKLGAVFRP IKLLGGLLLL AISVMIWISM LLTCIDKAKN SVCKQKCGYI LGKINIINPV
     NWVLVEAASV FPADYVIFIV LVLHLFTSSV VGIATIGIRF LWIRLLQIRK GHTSPQALLL
     ATVMLTLITL ALNYSISMIV VPQYATYGPQ TFCDYPSIPA SAPLDCSKHK EYLKPCSELA
     NNPAAKAVCT PSVASTFLNR ITLNFPFFGI VDFWAQFVFL GFSLIVLLIS LFRTPRFDEQ
     QMDEDAEEAE EEGLLAASGS RFNAAWQDTT GRTRDQRVRF RDDE