ID   LMBD1_MAGO7             Reviewed;         586 AA.
AC   A4RE85; G4NEP6;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=MGG_00740;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM001235; EHA48676.1; -; Genomic_DNA.
DR   RefSeq; XP_003718260.1; XM_003718212.1.
DR   AlphaFoldDB; A4RE85; -.
DR   SMR; A4RE85; -.
DR   STRING; 318829.MGG_00740T0; -.
DR   EnsemblFungi; MGG_00740T0; MGG_00740T0; MGG_00740.
DR   GeneID; 2674691; -.
DR   KEGG; mgr:MGG_00740; -.
DR   VEuPathDB; FungiDB:MGG_00740; -.
DR   eggNOG; ENOG502QQ2T; Eukaryota.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   InParanoid; A4RE85; -.
DR   OMA; IITTFTW; -.
DR   OrthoDB; 744771at2759; -.
DR   Proteomes; UP000009058; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..586
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365832"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        509..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        540
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   586 AA;  64887 MW;  1126C6B1665A93CC CRC64;
     MAPYLQTSLI WIAYAVAVGL ALFAAIVTTF TWQKPRERSA VVNTVAVVSL TSLLATVLLL
     PVDIALVSST GSVHLGVNKE WATPEHVAGM LRTLQIVYYS LYSLDALLCL IVIPFAYFWY
     EEYDEVEEEE GTRSTGAKLW GAFKYTSGFI ILVLILFFVG FFVPAAGNQK GGHLDLDYFK
     RLLAANKGEK ALTFAVGLLV CLGTLLYVLY TSSGLALLPI SFIKSAPSIS APQLSETTAS
     ALERNRERQR QLELRNGGNH DEMPSKDRRE LESLVREERT LVRRARLAAE AQGEGRSWVY
     RTWTKICAVF RPLKLVGGIL LLLVSVIVWV SMLITTIDKA SNSLCKGHCG YILGQIKIFQ
     PVNWLFLQAA KAFPVDYIIM AFLVLFFFSS SISGLATVGI RFLWVQIFQI RRGRTAPQAI
     LIATVMMALI ILGINYSIAM MAAPQYSIYG TQTFCTAEPT AHGKQPDCSE HPEMVRPCSE
     GFKQPLAKDI CTPSVMSTFL NRVTLNWPVF GAVDFWAQVA FLAVFLIVLV TSLFRTPKLN
     MSELDEEAEA DEEEGLLAST GRRFGATWQD ITGRSGQASN QENGDN