ID   LMBD1_NEOFI             Reviewed;         563 AA.
AC   A1DB12;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=NFIA_096740;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DS027694; EAW20052.1; -; Genomic_DNA.
DR   RefSeq; XP_001261949.1; XM_001261948.1.
DR   AlphaFoldDB; A1DB12; -.
DR   SMR; A1DB12; -.
DR   STRING; 36630.CADNFIAP00009090; -.
DR   EnsemblFungi; EAW20052; EAW20052; NFIA_096740.
DR   GeneID; 4588323; -.
DR   KEGG; nfi:NFIA_096740; -.
DR   VEuPathDB; FungiDB:NFIA_096740; -.
DR   eggNOG; ENOG502QQ2T; Eukaryota.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   OMA; IITTFTW; -.
DR   OrthoDB; 744771at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..563
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365834"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          537..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   563 AA;  63398 MW;  6025D60513EA91FC CRC64;
     MPLPWISLIW FAYLIVITVL IVVASVFIHV YQTPRDRSSF VTFMCVFSIA ALLATVMLLP
     VDVALVSSTT SSALGQRKEW ATQEEVDKIT YSLTVIYYSL YFLDALLCLV GIPFAYFWHE
     EYDEVAFEAG DQTPCKRFWA ATKYTLAFIA VVIALVLVGF FAPMSESQPG HDLGYWRGFL
     IENRGEHAFT FLLGFVTTIG SCLYVFYTPS GLALLPALFL RRSYSFANQT LVGSTAMQLD
     FNRERQRQLE GRCGGNSALL SPKDRRELDT LVREERTLIR RQRLIEGRQE EDQSWPVTVY
     SKLKTILRPF RLLGGFSLFL VGLSTWISLL MTVIDKLINS PCKHHCGYVL SRTNFNPISW
     LLIQSSRAFP TDYIIFALIV FLFFWGSVVG VVAVGIRFLW IRIFQIRKGH TSPQAMLLAT
     AMLTLITLGL NYSVVMMLAP RYATFGPQTF CDLAPTSSEE QPDCSNHWHL VKPCSEKADS
     TAADNTCTPS VASTILNRVA LNFPLFGALL LWAHFLFLGI YLVILVASLV RSPRLDERQL
     DEDAEEAEEE SLLASTGRSG NPT