ID   LMBD1_PODAN             Reviewed;         596 AA.
AC   B2AA26; A0A090CBS9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   OrderedLocusNames=Pa_1_2600; ORFNames=PODANS_1_2600;
OS   Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS   (Pleurage anserina).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC   Podospora anserina.
OX   NCBI_TaxID=515849;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX   PubMed=18460219; DOI=10.1186/gb-2008-9-5-r77;
RA   Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M.,
RA   Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V.,
RA   Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M.,
RA   Contamine V., Arnaise S., Bourdais A., Berteaux-Lecellier V., Gautheret D.,
RA   de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B.,
RA   El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H.,
RA   Debuchy R., Wincker P., Weissenbach J., Silar P.;
RT   "The genome sequence of the model ascomycete fungus Podospora anserina.";
RL   Genome Biol. 9:R77.1-R77.22(2008).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX   PubMed=24558260; DOI=10.1534/genetics.113.159988;
RA   Grognet P., Bidard F., Kuchly C., Tong L.C.H., Coppin E., Benkhali J.A.,
RA   Couloux A., Wincker P., Debuchy R., Silar P.;
RT   "Maintaining two mating types: Structure of the mating type locus and its
RT   role in heterokaryosis in Podospora anserina.";
RL   Genetics 197:421-432(2014).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CU633438; CAP59937.1; -; Genomic_DNA.
DR   EMBL; FO904936; CDP22579.1; -; Genomic_DNA.
DR   RefSeq; XP_001912456.1; XM_001912421.1.
DR   AlphaFoldDB; B2AA26; -.
DR   SMR; B2AA26; -.
DR   STRING; 5145.XP_001912456.1; -.
DR   EnsemblFungi; CAP59937; CAP59937; PODANS_1_2600.
DR   GeneID; 6196704; -.
DR   KEGG; pan:PODANSg09504; -.
DR   VEuPathDB; FungiDB:PODANS_1_2600; -.
DR   eggNOG; ENOG502QQ2T; Eukaryota.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   OrthoDB; 744771at2759; -.
DR   Proteomes; UP000001197; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..596
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365837"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        512..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          576..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        543
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   596 AA;  65530 MW;  381FC7307DA1128A CRC64;
     MLASAGLLQT SLIWVAYAVA VALVLLVAII TTFTWQSPHE RSVTVSIVAI VSLTSLLATV
     FLLPVDIALV SSTASAHLGA KKDWATPERI DGILLTLKVV YYTLYSFDAL LCLIVIPFAY
     FWYEEYDEVE EEEGTSGAGA RFWKAAKYTL GFVFLVLILF LLGFFVPAAG SGNGKHLDLD
     YFKRLLAANK GEKALTFGVG LLITLGTFLY TLYTGAGLAL LPVSLIKSAP SISAPQLSAT
     IATDLEHNRE LQRQIEMRNA GRPDGISQKD RRELDALLRE ERTLVRRERL AAETRGDGRS
     GVFRAWTKIQ AVFRPLKLLG GILLLLLSIL VWASMLITGI DKAANSICKE HCGYILGHIN
     VFQPVNWIFV QSAKAFPVDY ILMALLVLFF FGSSITGIAT IGIRFLWVRV FQIKKGRTSP
     QALLIATVML ALIILAINYA IAMIVAPQYA IYGTQTFCVN APRHPGEQPD CREHRDMVRP
     CSEVFSEPAA KDVCTPTVMS TFLNRVTINW PVFGAIDFWA QFAFLGVFMV VFVTSLFRTP
     RLNLSELDEE AEVDEEEGLL ASTGRRFGAT WGDITGRAKN RNGYGTGGGE GSNGRG