ID   LMBD1_PYRTR             Reviewed;         591 AA.
AC   B2WCU2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=PTRG_07801;
OS   Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus)
OS   (Drechslera tritici-repentis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC   Pyrenophora.
OX   NCBI_TaxID=426418;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pt-1C-BFP;
RX   PubMed=23316438; DOI=10.1534/g3.112.004044;
RA   Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B.,
RA   Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H.,
RA   Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W.,
RA   Schwartz D.C., Spatafora J.W., Turgeon B.G., Yandava C., Young S., Zhou S.,
RA   Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.;
RT   "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-
RT   repentis, reveals transduplication and the impact of repeat elements on
RT   pathogenicity and population divergence.";
RL   G3 (Bethesda) 3:41-63(2013).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DS231622; EDU50720.1; -; Genomic_DNA.
DR   RefSeq; XP_001938133.1; XM_001938098.1.
DR   AlphaFoldDB; B2WCU2; -.
DR   SMR; B2WCU2; -.
DR   STRING; 426418.B2WCU2; -.
DR   EnsemblFungi; EDU50720; EDU50720; PTRG_07801.
DR   GeneID; 6346075; -.
DR   eggNOG; ENOG502QQ2T; Eukaryota.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   InParanoid; B2WCU2; -.
DR   OMA; IITTFTW; -.
DR   OrthoDB; 744771at2759; -.
DR   Proteomes; UP000001471; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..591
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365838"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        509..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          238..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..266
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   591 AA;  65813 MW;  6CC727024434D17D CRC64;
     MALIQTSLIW VAYAVAVAIL FLIASTFVYV YQKPRDRAAA VTIVCIFTTL ALLATVLLIP
     VDVALVSSTS RSSLGRKKDW ATPDKVDSIV YTLRIVYYTL YSLDAVLCLL VIPFTYFWYE
     EYDQDAAEHG EQTAAQRIGG ALKWTLGFLI FVVAIFLVGF FVPFAKQAKE DKRLDLDYFK
     HLLSENHGER ALSFGLGFLI TVGTVLFVLY TGAGMALLPV AMIKSAPSVS APTLAANTAS
     QLETNRERQR QLEGRNEGRE GGLDSRDRRE LEALVREERT LIRRERLAAE SSGEDRHWIV
     KAWIKTEAFF RPLKLIGGLI LLVFALVIFA SMLITGIDKA KNSICGAHCG YILGHINIFQ
     PLNWVLVKSA KVFPIDYVLF LLLVLFLFSA SVVGIATAGI RFLWVTIFKI RKGQTSPQAL
     LMATVLLTLI TLAINYSVAM VVAPQYATWG PQTYCDMKTN SLDEQPDCAE HKDLIKPCSE
     LATNPAAQQV CTPSVLSTFI NRVTINFPFF GIVLFWAQFA FLGVYLIVFL TTLFKAPTLD
     QEQIDRDLEE EEDEGLLAST GRRFGAAWSD VTGRATKPAN YGATERDERI Q