ID   LMBD1_SCLS1             Reviewed;         596 AA.
AC   A7F2V9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=SS1G_12257;
OS   Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS   (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=665079;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18683 / 1980 / Ss-1;
RX   PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC       cobalamin from lysosomes allowing its conversion to cofactors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CH476639; EDN96051.1; -; Genomic_DNA.
DR   RefSeq; XP_001587227.1; XM_001587177.1.
DR   AlphaFoldDB; A7F2V9; -.
DR   SMR; A7F2V9; -.
DR   STRING; 665079.A7F2V9; -.
DR   EnsemblFungi; EDN96051; EDN96051; SS1G_12257.
DR   GeneID; 5483347; -.
DR   KEGG; ssl:SS1G_12257; -.
DR   VEuPathDB; FungiDB:sscle_05g042210; -.
DR   eggNOG; ENOG502QQ2T; Eukaryota.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   InParanoid; A7F2V9; -.
DR   OMA; IITTFTW; -.
DR   Proteomes; UP000001312; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0072665; P:protein localization to vacuole; IBA:GO_Central.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..596
FT                   /note="Probable lysosomal cobalamin transporter"
FT                   /id="PRO_0000365839"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        507..527
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          566..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   596 AA;  65749 MW;  EBAC164E917A16CE CRC64;
     MALIQTAFIW VAYAVAVGIV ALIAAIFAYT YQTPRDRSAL VSTITIITLT SLLATVLLLP
     VDIALVSSTT SSKLGAKKDW ATPETVRNIL LTLKIVYYAL YSLDAVLCLL VIPFTYFFYE
     EYDEVDTEEG TQTLGQRLLG AAKYTLFFVV LVVILFLVGF FAPVARGGGS DMDLDYFKRL
     LAENHGERAL TFALGLLISL GTLLYILYTS VGLALLPMSF IKSAPSISAP QLSETTASAL
     EQNRERQRQL EGRNVGRNAG LSAKDQRELE ALHREERTLV RRERLAAEAR GEGKSFIVKA
     WTKTCAIFRP LKLVGGILLL LLSVIIWASM LITGIDKAKN SFCKQHCGYI LGSINIFQPL
     NWVFVKSSIV FPIDYVLMAL LVLFLFSSSV TGIAVIGLRF LWVRLFEIRK GHTSPQALLM
     ATVMLTLIIL AINYSIAMII APQYAIYGAQ TFCTNPTRFP GDQPDCSNHP ELIKTCSELS
     SGEGAEKVCT PTVVSTFLNR VTVNFPFFGA LAFWAQFVFL AIFLIVFVTA LFRTPKLDLS
     ELDEDAEADE EEGLLATTGR RFGATWQDIR GKAKNQTPSR GAAGRGIRGD DDHDDD