LMBD2_DROME
ID LMBD2_DROME Reviewed; 694 AA.
AC Q8MRQ4; Q9VHE2;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=LMBR1 domain-containing protein 2 homolog;
GN ORFNames=CG8135;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LIMR family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54372.1; -; Genomic_DNA.
DR EMBL; AY119474; AAM50128.1; -; mRNA.
DR RefSeq; NP_649890.1; NM_141633.2.
DR AlphaFoldDB; Q8MRQ4; -.
DR SMR; Q8MRQ4; -.
DR IntAct; Q8MRQ4; 1.
DR STRING; 7227.FBpp0081508; -.
DR GlyGen; Q8MRQ4; 2 sites.
DR PaxDb; Q8MRQ4; -.
DR PRIDE; Q8MRQ4; -.
DR EnsemblMetazoa; FBtr0082030; FBpp0081508; FBgn0037689.
DR GeneID; 41123; -.
DR KEGG; dme:Dmel_CG8135; -.
DR UCSC; CG8135-RA; d. melanogaster.
DR FlyBase; FBgn0037689; CG8135.
DR VEuPathDB; VectorBase:FBgn0037689; -.
DR eggNOG; KOG2296; Eukaryota.
DR GeneTree; ENSGT00390000018651; -.
DR HOGENOM; CLU_018886_0_0_1; -.
DR InParanoid; Q8MRQ4; -.
DR OMA; ERICYSA; -.
DR PhylomeDB; Q8MRQ4; -.
DR BioGRID-ORCS; 41123; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41123; -.
DR PRO; PR:Q8MRQ4; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037689; Expressed in male reproductive gland and 10 other tissues.
DR Genevisible; Q8MRQ4; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR Pfam; PF04791; LMBR1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..694
FT /note="LMBR1 domain-containing protein 2 homolog"
FT /id="PRO_0000299168"
FT TOPO_DOM 1..3
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 403..426
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 448..467
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 468..488
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 489..514
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 536..694
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 673..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 222..249
FT /evidence="ECO:0000255"
FT COILED 564..592
FT /evidence="ECO:0000255"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 393
FT /note="M -> I (in Ref. 1; AAM50128)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 694 AA; 78440 MW; 8AA0B5A660239875 CRC64;
MAYLLSFGIV AALFLASISL YRYGNIPRQH ILVTLSVLTA WCFSFLIVFT IPLDVTSTLY
RQCVEEHRPT PAPNVTNTSS ATVGPPPQCQ EPWGMVPASV FPNLWRIIYW SSQFLTWLIM
PLMQSYLKAG DFTVKGKLKS ALIENAIYYG SYLFICGVLL IYIAVKGESL DWQKLKAIAS
SASNTWGLFL LILLLGYALV EVPRSLWNNA KPGFALQYAY FKAAKLSTEK AEAEEHVDDI
LESLQGLSRV IPNNHELRPC LETILRKVPI ELQERASRNF ARTGGSGMGA TSSTILPSEK
ALVRIHKQVI KSLQTLQRTE ALWSVQVQTV LHLEDVAKNI HSSDRRFKSE FPRQRTQLER
ICYSASLQWY WECLLKAPFL KTMCVLTATM SAMVVWSELT FFSRHPVLSI FANVIYVAKE
SYDFFTIEVF SMVVLCYFFY CTYSTILRIR FLNLYYLAPH HQTNEHSLIF SGMLLCRLTP
PMCLNFLGLI HMDTHIIPNR IMETVYTQIM GHMDVIGIIS NGFNIYFPMC MLAFCLATWF
SLGSRALNAL GFQQFLQNET IATELVQEGK DLIAREKRRR QRAEEAMARR RDFNRTDQVL
GSDYLSKYRS GGPGGLTSSR TPADGLLRDG DGSFDYAAVA SSSALGVPRS LSEEINDRFG
VSTQVQVGFR DPDYEAETDG RIVGPPPRGL FDDV
