ID   LMBD2_XENLA             Reviewed;         713 AA.
AC   Q7ZYA0;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=G-protein coupled receptor-associated protein LMBRD2 {ECO:0000250|UniProtKB:Q68DH5};
DE   AltName: Full=LMBR1 domain-containing protein 2;
GN   Name=lmbrd2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May associate with G-protein coupled receptors and regulate
CC       downstream signaling pathways. {ECO:0000250|UniProtKB:Q68DH5}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q68DH5};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the LIMR family. {ECO:0000305}.
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DR   EMBL; BC043881; AAH43881.1; -; mRNA.
DR   RefSeq; NP_001080584.1; NM_001087115.1.
DR   AlphaFoldDB; Q7ZYA0; -.
DR   SMR; Q7ZYA0; -.
DR   PRIDE; Q7ZYA0; -.
DR   DNASU; 380276; -.
DR   GeneID; 380276; -.
DR   KEGG; xla:380276; -.
DR   CTD; 380276; -.
DR   Xenbase; XB-GENE-991218; lmbrd2.L.
DR   OrthoDB; 778022at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 380276; Expressed in testis and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071875; P:adrenergic receptor signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..713
FT                   /note="G-protein coupled receptor-associated protein
FT                   LMBRD2"
FT                   /id="PRO_0000299165"
FT   TOPO_DOM        1..3
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..32
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..122
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..167
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        189..203
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        225..404
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        426..449
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        471..490
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        491..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        512..538
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        539..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        560..713
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          600..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          246..314
FT                   /evidence="ECO:0000255"
FT   COILED          587..620
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        600..633
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..654
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        655..670
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        697..713
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   713 AA;  82694 MW;  7804C52BABBC1F4F CRC64;
     MSGVALGIEI VSVFFLALFL LHRYGDFKKQ HKLVIVGTLL AWYLCFLIVF IIPLDVSTTI
     YNRCVARHAV TPAPSNITVL SPTPGIVSNT TAQNHLPSAD KLRSSDNSLE ECSKPWSYIP
     RGIMPIFWRV VYWTSQFLTW ILMPFMQSYA RSGGFSITGK IKTALIENAI YYGTYLLIFG
     ALLIYVAVNP NLHLEWYQLQ TIGIAAANTW GLFLLVLLMG YGLVEIPRSQ WNGAKKGYLL
     MKTYFKAAKL MTEKADAEET LEDVMEEVRK VNECIKYNHP LRKCVDTILK KCPAEYQEKM
     GRNMDDYEDF EEKNISYPSE KTLVKLHKQV IYAVQRHRRT QVQWSILLEQ AFHLEDVAKN
     ETSAAKQFVH TFPHQEPESW IMRRLYTPTI EWYWECLLRP WCSRILAVIL ALFSTVVVWS
     ECTFFSAKPV LSLFAVFIQQ AEQTHNYIYV EVVCFLSIFF LSICVYSTVF RIRVFNYYYL
     ASHHQTDAYS LLFSGMLFCR LTPPLCLNFL GLTHMDVSIS HQNIEPTAYT SIMGSLRVLP
     LIADVFYIYY PMLVLILCIA TYFSLGTRCL NLLGFQQFMG DNDMTSDLTD EGKELIKREK
     RKRQRLEDGE TRRREWKERY PTNREDTSRN RSVNSDQKEP TYTEMTTNRS SKYTRASNRT
     ERDRIELLQD AEPLDFNADT FNDDPLDSES GRYQPGGRYL SMSQSNSRIF DDV