LMBR1_MOUSE
ID LMBR1_MOUSE Reviewed; 490 AA.
AC Q9JIT0; Q766D0; Q91WC6; Q9JIS9;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Limb region 1 protein;
GN Name=Lmbr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=B10.D2/nSn;
RX PubMed=10945466; DOI=10.1006/geno.2000.6225;
RA Clark R.M., Marker P.C., Kingsley D.M.;
RT "A novel candidate gene for mouse and human preaxial polydactyly with
RT altered expression in limbs of hemimelic extra-toes mutant mice.";
RL Genomics 67:19-27(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-141.
RX PubMed=14727139; DOI=10.1007/s00335-033-2317-5;
RA Sagai T., Masuya H., Tamura M., Shimizu K., Yada Y., Wakana S., Gondo Y.,
RA Noda T., Shiroishi T.;
RT "Phylogenetic conservation of a limb-specific, cis-acting regulator of
RT Sonic hedgehog (Shh).";
RL Mamm. Genome 15:23-34(2004).
CC -!- FUNCTION: Putative membrane receptor.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=LMBR1L;
CC IsoId=Q9JIT0-1; Sequence=Displayed;
CC Name=2; Synonyms=LMBR1S;
CC IsoId=Q9JIT0-2; Sequence=VSP_016889, VSP_016890;
CC Name=3;
CC IsoId=Q9JIT0-3; Sequence=VSP_016891;
CC -!- SIMILARITY: Belongs to the LIMR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD07410.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF190665; AAF91092.1; -; mRNA.
DR EMBL; AF190666; AAF91093.1; -; mRNA.
DR EMBL; BC016110; AAH16110.1; -; mRNA.
DR EMBL; AB114903; BAD07410.1; ALT_FRAME; Genomic_DNA.
DR CCDS; CCDS19148.1; -. [Q9JIT0-1]
DR RefSeq; NP_064691.2; NM_020295.3. [Q9JIT0-1]
DR AlphaFoldDB; Q9JIT0; -.
DR STRING; 10090.ENSMUSP00000058405; -.
DR PhosphoSitePlus; Q9JIT0; -.
DR MaxQB; Q9JIT0; -.
DR PaxDb; Q9JIT0; -.
DR PRIDE; Q9JIT0; -.
DR ProteomicsDB; 290044; -. [Q9JIT0-1]
DR ProteomicsDB; 290046; -. [Q9JIT0-3]
DR Antibodypedia; 18896; 149 antibodies from 22 providers.
DR DNASU; 56873; -.
DR Ensembl; ENSMUST00000055195; ENSMUSP00000058405; ENSMUSG00000010721. [Q9JIT0-1]
DR Ensembl; ENSMUST00000198105; ENSMUSP00000142755; ENSMUSG00000010721. [Q9JIT0-3]
DR GeneID; 56873; -.
DR KEGG; mmu:56873; -.
DR UCSC; uc008wug.1; mouse. [Q9JIT0-1]
DR UCSC; uc012dtv.1; mouse. [Q9JIT0-3]
DR CTD; 64327; -.
DR MGI; MGI:1861746; Lmbr1.
DR VEuPathDB; HostDB:ENSMUSG00000010721; -.
DR eggNOG; KOG3722; Eukaryota.
DR GeneTree; ENSGT00390000007809; -.
DR HOGENOM; CLU_029445_1_0_1; -.
DR InParanoid; Q9JIT0; -.
DR OMA; YFIIRRY; -.
DR OrthoDB; 768229at2759; -.
DR PhylomeDB; Q9JIT0; -.
DR TreeFam; TF313485; -.
DR BioGRID-ORCS; 56873; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Lmbr1; mouse.
DR PRO; PR:Q9JIT0; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9JIT0; protein.
DR Bgee; ENSMUSG00000010721; Expressed in spermatid and 245 other tissues.
DR ExpressionAtlas; Q9JIT0; baseline and differential.
DR Genevisible; Q9JIT0; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISO:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR008075; LIMR.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR12625; PTHR12625; 1.
DR Pfam; PF04791; LMBR1; 2.
DR PRINTS; PR01692; LIPOCALINIMR.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Membrane; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..490
FT /note="Limb region 1 protein"
FT /id="PRO_0000053907"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..339
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..383
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 405..426
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 448..490
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT COILED 256..287
FT /evidence="ECO:0000255"
FT VAR_SEQ 23..32
FT /note="ICFLLFAILY -> RNGRFTSYLW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10945466"
FT /id="VSP_016889"
FT VAR_SEQ 33..490
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10945466"
FT /id="VSP_016890"
FT VAR_SEQ 107..133
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016891"
SQ SEQUENCE 490 AA; 55115 MW; 869184C2F0729C91 CRC64;
MEGQDEVSAR EQHFHSQVRE STICFLLFAI LYIVSYFIII RYKRKSDEQE DEDAVVNRIS
LFLSTFTLAV SAGAVLLLPF SIISNEILLA FPHNYYIQWL NGSLIHGLWN LASLFSNLCL
FVLMPFAFFF LESEGFAGLK KGIRARILET LVMLLLLALL ILGMVWVASA LIDSDAASME
SLYDLWEFYL PYLYSCISLM GCLLLLLCTP VGLSRMFTVM GQLLVKPAIL EDLDEQIYMI
TLEEEALQRR LHGLSSSVEY NVMELEQELE NVKILKTKLE RRKKASAWER NLVYPAVMVL
LLIETSISVL LVACNILCLL VDETAMPKGT RGPGIGSASL STFGFVGAAL EIILIFYLMV
SSVVGFYSLR FFGNFTPKKD DTTMTKIIGN CVSILVLSSA LPVMSRTLGI TRFDLLGDFG
RFNWLGNFYI VLSYNLLFAI MTTLCLIRKF TSAVREELFK ALGLHKLHLS DTSRDSETTK
PSANGHQKAL
