ID   LMBR1_XENTR             Reviewed;         485 AA.
AC   Q5U4X7;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Limb region 1 protein homolog;
GN   Name=lmbr1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative membrane receptor.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. {ECO:0000305}.
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DR   EMBL; BC084916; AAH84916.1; -; mRNA.
DR   RefSeq; NP_001011160.1; NM_001011160.1.
DR   RefSeq; XP_012820042.1; XM_012964588.2.
DR   AlphaFoldDB; Q5U4X7; -.
DR   STRING; 8364.ENSXETP00000036627; -.
DR   DNASU; 496578; -.
DR   GeneID; 496578; -.
DR   KEGG; xtr:496578; -.
DR   CTD; 64327; -.
DR   Xenbase; XB-GENE-981846; lmbr1.
DR   eggNOG; KOG3722; Eukaryota.
DR   InParanoid; Q5U4X7; -.
DR   OrthoDB; 768229at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013512; Expressed in testis and 17 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR008075; LIMR.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   PANTHER; PTHR12625; PTHR12625; 1.
DR   Pfam; PF04791; LMBR1; 2.
DR   PRINTS; PR01692; LIPOCALINIMR.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Receptor; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..485
FT                   /note="Limb region 1 protein homolog"
FT                   /id="PRO_0000053909"
FT   TOPO_DOM        1..18
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..61
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        83..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        213..290
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        312..338
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        360..382
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        404..425
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        447..485
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   COILED          261..284
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   485 AA;  54690 MW;  95B3F74F0190F58D CRC64;
     MEEDEVTIRE QNFYSQVREC IICFLLFAIL YIVSYFIIKR YKRKGDEQED EDATVNRVSL
     FLCTFTLAVS GGAVLLLPFS IISNEILLCF PKSYYIQWLN GSLIHGLWNL VSLFSNLCLF
     VLMPFAFFFL ESEGFAGLKK GIKARILETI IMLILLALLI FGIVWVASAL IDNSSASMES
     LYDLWDCYLP YLYSCISLMG CLLLLLCTPV GLSRMFTVMG QLLVKPTILE DIDEQMYIIS
     LQEEALQRKL NGGNYTADYS RKKIEHDLLN ARSMKSKLER RKNASAWQRN LVYPAVMILL
     LIATFSSVIL VSLNILRLLV DETAMPKGSK GSGFGDASLF TFGFAGATLE IILIFYLMVS
     SVVGFYSLRF FSSFTPRKDD TTMTKVIGNC LSILVLSSAL PVMSRTLGIT RFDLLGDFGR
     FNWLGNFYIV VAYNLMFAVM TTLCLVRKFT SAVREELLKA IGLDRLQLSN KSSDSPSPNG
     HQKSL