ID   LMBRL_DANRE             Reviewed;         491 AA.
AC   Q803C7;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Limb region 1 homolog-like protein;
GN   Name=lmbr1l; ORFNames=zgc:55912;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in lymphocyte development by negatively
CC       regulating the canonical Wnt signaling pathway (By similarity). May act
CC       as a LCN1 receptor (By similarity). {ECO:0000250|UniProtKB:Q6UX01,
CC       ECO:0000250|UniProtKB:Q9D1E5}.
CC   -!- SUBUNIT: Dimer (By similarity). Can also form higher oligomers (By
CC       similarity). {ECO:0000250|UniProtKB:Q6UX01}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6UX01};
CC       Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum
CC       membrane {ECO:0000250|UniProtKB:Q6UX01}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the LIMR family. {ECO:0000305}.
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DR   EMBL; BC044535; AAH44535.1; -; mRNA.
DR   RefSeq; NP_942575.1; NM_198874.1.
DR   AlphaFoldDB; Q803C7; -.
DR   STRING; 7955.ENSDARP00000019361; -.
DR   PaxDb; Q803C7; -.
DR   Ensembl; ENSDART00000027224; ENSDARP00000019361; ENSDARG00000004745.
DR   GeneID; 321314; -.
DR   KEGG; dre:321314; -.
DR   CTD; 55716; -.
DR   ZFIN; ZDB-GENE-030131-9906; lmbr1l.
DR   eggNOG; KOG3722; Eukaryota.
DR   GeneTree; ENSGT00390000007809; -.
DR   HOGENOM; CLU_029445_1_0_1; -.
DR   InParanoid; Q803C7; -.
DR   OMA; NCSAFEE; -.
DR   OrthoDB; 768229at2759; -.
DR   PhylomeDB; Q803C7; -.
DR   TreeFam; TF313485; -.
DR   PRO; PR:Q803C7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000004745; Expressed in blastula and 34 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR008075; LIMR.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   PANTHER; PTHR12625; PTHR12625; 1.
DR   Pfam; PF04791; LMBR1; 2.
DR   PRINTS; PR01692; LIPOCALINIMR.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endocytosis; Endoplasmic reticulum; Membrane; Receptor;
KW   Reference proteome; Transmembrane; Transmembrane helix;
KW   Wnt signaling pathway.
FT   CHAIN           1..491
FT                   /note="Limb region 1 homolog-like protein"
FT                   /id="PRO_0000053915"
FT   TOPO_DOM        1..20
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..111
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..152
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..292
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        314..346
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        368..384
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        406..427
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        449..491
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   491 AA;  55147 MW;  36D4075E6411FF22 CRC64;
     METEDVTVRE QIFHDRVRET IICVLLFICL YILSHFILTH FKKSAEFVTD DIEDATVNKI
     ALWLCTFTLS VAVCAVLLLP ISILSNEVLL TFPHSYYMQW LNGSLIRGLW NLVFLFSNLS
     LVFLMPFAYF FTESEGFAGS KKGVMARVYE TAVMLLLLSL LVLGIVWVAS ALLHHNTARE
     SLYDLWEYYL PYLYSGISLF GVLLLLLCTP FGLSRMFSVT GSLLVKPRLL ENLEETMNCA
     VFEEASLSRK LKSTNTCWIS AHLEALNKEF LSVQSKRITL ELRKRASPWQ RNLVYPVAML
     LLLALTAVSV LMVCFHVLEL LFDESAMPRG MEDPHLGLAS FSMLGSLGAA VQVVIILYLM
     VSSVVGFYSS PLFTGLLPRA QDTTLTQIIG NCVSLLILSS ALPVFSRTLG ITKFDLLGDF
     GRHDWLGSFH IVFLYNMLFA GLTSACLINT VTWALQRELI RAFGLHRLPL TVSRSTIPLK
     LLLANGLSKI H