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LMBRL_MACFA
ID   LMBRL_MACFA             Reviewed;         489 AA.
AC   Q4R7X9;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Protein LMBR1L;
DE   AltName: Full=Lipocalin-1-interacting membrane receptor {ECO:0000250|UniProtKB:Q6UX01};
DE            Short=LIMR {ECO:0000250|UniProtKB:Q6UX01};
GN   Name=LMBR1L; ORFNames=QtsA-14131;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in lymphocyte development by
CC       negatively regulating the canonical Wnt signaling pathway (By
CC       similarity). In association with UBAC2 and E3 ubiquitin-protein ligase
CC       AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt
CC       receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-
CC       catenin destruction complex that is required for regulating CTNNB1
CC       levels (By similarity). Acts as a LCN1 receptor and can mediate its
CC       endocytosis (By similarity). {ECO:0000250|UniProtKB:Q6UX01,
CC       ECO:0000250|UniProtKB:Q9D1E5}.
CC   -!- SUBUNIT: Dimer (By similarity). Can also form higher oligomers (By
CC       similarity). Interacts with LCN1; this interaction mediates the
CC       endocytosis of LCN1 (By similarity). Interacts with UBAC2, FAF2, VCP,
CC       AMFR, ZNRF3, CTNNB1, LRP6, GSK3A, GSK3B, FZD6, DVL2 and RNF43 (By
CC       similarity). Interaction with LGB and SCGB1A1 is controversial (By
CC       similarity). {ECO:0000250|UniProtKB:Q6UX01,
CC       ECO:0000250|UniProtKB:Q9D1E5}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6UX01};
CC       Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum
CC       membrane {ECO:0000250|UniProtKB:Q6UX01}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the LIMR family. {ECO:0000305}.
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DR   EMBL; AB168682; BAE00793.1; -; mRNA.
DR   RefSeq; XP_005570811.1; XM_005570754.2.
DR   AlphaFoldDB; Q4R7X9; -.
DR   STRING; 9541.XP_005570810.1; -.
DR   Ensembl; ENSMFAT00000066199; ENSMFAP00000015672; ENSMFAG00000031019.
DR   GeneID; 102126507; -.
DR   KEGG; mcf:102126507; -.
DR   CTD; 55716; -.
DR   VEuPathDB; HostDB:ENSMFAG00000031019; -.
DR   eggNOG; KOG3722; Eukaryota.
DR   GeneTree; ENSGT00390000007809; -.
DR   OMA; NCSAFEE; -.
DR   Proteomes; UP000233100; Chromosome 11.
DR   Bgee; ENSMFAG00000031019; Expressed in lymph node and 13 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR   GO; GO:0060218; P:hematopoietic stem cell differentiation; ISS:UniProtKB.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR   GO; GO:0070231; P:T cell apoptotic process; ISS:UniProtKB.
DR   GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
DR   GO; GO:0042098; P:T cell proliferation; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR008075; LIMR.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   PANTHER; PTHR12625; PTHR12625; 1.
DR   Pfam; PF04791; LMBR1; 2.
DR   PRINTS; PR01692; LIPOCALINIMR.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endocytosis; Endoplasmic reticulum; Membrane; Receptor;
KW   Reference proteome; Transmembrane; Transmembrane helix;
KW   Wnt signaling pathway.
FT   CHAIN           1..489
FT                   /note="Protein LMBR1L"
FT                   /id="PRO_0000053911"
FT   TOPO_DOM        1..21
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..66
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..114
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..154
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..305
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        327..350
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        372..388
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        410..431
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        432..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        453..489
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..76
FT                   /note="LCN1-binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q6UX01"
FT   REGION          1..59
FT                   /note="Interaction with LGB"
FT                   /evidence="ECO:0000250|UniProtKB:Q6UX01"
SQ   SEQUENCE   489 AA;  55048 MW;  19985D0412774E0B CRC64;
     MEAPDCEVLS VREQLFHERI RECIISTLLF ATLYILCHIF LTRFKKPAEF TTVDDADATV
     NKIALELCTF TLAIALGAVL LLPFSIISNE VLLSLPRNYY IQWLNGSLIH GLWNLVFLFS
     NLSLIFLMPF AYFFTESEGF AGSRKGVLGR VYETVVMLML LTLLVLGMVW VASAIVDNNK
     ASRESLYDFW EYYLPYLYSC ISFLGVLLLL VCTPLGLARM FSVTGKLLVK PRLLEDLEEQ
     LYCSAFEEAA LTRRICNPTS CWLPLDMELL HRQLLALQTQ RVLLEKRRKA SAWQRNLGYP
     LAMLCLLVLT GLSVLIVAIH ILELLIDEAA MPRGMQGASL GQVSFSKLGS FGAVVQVVLI
     FYLMVSSVVG FYSSPLFRSL RPRWHDTAMT QIIGNCVCLL VLSSALPVFS RTLGLTRFDL
     LGDFGRFNWL GNFYIVFLYN AAFAGLTTLC LVKTFTAAVR AELIRAFGLD RLPLPVSGFP
     RASRKTQHQ
 
 
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