LMBRL_MACFA
ID LMBRL_MACFA Reviewed; 489 AA.
AC Q4R7X9;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Protein LMBR1L;
DE AltName: Full=Lipocalin-1-interacting membrane receptor {ECO:0000250|UniProtKB:Q6UX01};
DE Short=LIMR {ECO:0000250|UniProtKB:Q6UX01};
GN Name=LMBR1L; ORFNames=QtsA-14131;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an essential role in lymphocyte development by
CC negatively regulating the canonical Wnt signaling pathway (By
CC similarity). In association with UBAC2 and E3 ubiquitin-protein ligase
CC AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt
CC receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-
CC catenin destruction complex that is required for regulating CTNNB1
CC levels (By similarity). Acts as a LCN1 receptor and can mediate its
CC endocytosis (By similarity). {ECO:0000250|UniProtKB:Q6UX01,
CC ECO:0000250|UniProtKB:Q9D1E5}.
CC -!- SUBUNIT: Dimer (By similarity). Can also form higher oligomers (By
CC similarity). Interacts with LCN1; this interaction mediates the
CC endocytosis of LCN1 (By similarity). Interacts with UBAC2, FAF2, VCP,
CC AMFR, ZNRF3, CTNNB1, LRP6, GSK3A, GSK3B, FZD6, DVL2 and RNF43 (By
CC similarity). Interaction with LGB and SCGB1A1 is controversial (By
CC similarity). {ECO:0000250|UniProtKB:Q6UX01,
CC ECO:0000250|UniProtKB:Q9D1E5}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6UX01};
CC Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum
CC membrane {ECO:0000250|UniProtKB:Q6UX01}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the LIMR family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB168682; BAE00793.1; -; mRNA.
DR RefSeq; XP_005570811.1; XM_005570754.2.
DR AlphaFoldDB; Q4R7X9; -.
DR STRING; 9541.XP_005570810.1; -.
DR Ensembl; ENSMFAT00000066199; ENSMFAP00000015672; ENSMFAG00000031019.
DR GeneID; 102126507; -.
DR KEGG; mcf:102126507; -.
DR CTD; 55716; -.
DR VEuPathDB; HostDB:ENSMFAG00000031019; -.
DR eggNOG; KOG3722; Eukaryota.
DR GeneTree; ENSGT00390000007809; -.
DR OMA; NCSAFEE; -.
DR Proteomes; UP000233100; Chromosome 11.
DR Bgee; ENSMFAG00000031019; Expressed in lymph node and 13 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; ISS:UniProtKB.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0070231; P:T cell apoptotic process; ISS:UniProtKB.
DR GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
DR GO; GO:0042098; P:T cell proliferation; ISS:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR008075; LIMR.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR12625; PTHR12625; 1.
DR Pfam; PF04791; LMBR1; 2.
DR PRINTS; PR01692; LIPOCALINIMR.
PE 2: Evidence at transcript level;
KW Cell membrane; Endocytosis; Endoplasmic reticulum; Membrane; Receptor;
KW Reference proteome; Transmembrane; Transmembrane helix;
KW Wnt signaling pathway.
FT CHAIN 1..489
FT /note="Protein LMBR1L"
FT /id="PRO_0000053911"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..114
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..350
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..388
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 410..431
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 453..489
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..76
FT /note="LCN1-binding"
FT /evidence="ECO:0000250|UniProtKB:Q6UX01"
FT REGION 1..59
FT /note="Interaction with LGB"
FT /evidence="ECO:0000250|UniProtKB:Q6UX01"
SQ SEQUENCE 489 AA; 55048 MW; 19985D0412774E0B CRC64;
MEAPDCEVLS VREQLFHERI RECIISTLLF ATLYILCHIF LTRFKKPAEF TTVDDADATV
NKIALELCTF TLAIALGAVL LLPFSIISNE VLLSLPRNYY IQWLNGSLIH GLWNLVFLFS
NLSLIFLMPF AYFFTESEGF AGSRKGVLGR VYETVVMLML LTLLVLGMVW VASAIVDNNK
ASRESLYDFW EYYLPYLYSC ISFLGVLLLL VCTPLGLARM FSVTGKLLVK PRLLEDLEEQ
LYCSAFEEAA LTRRICNPTS CWLPLDMELL HRQLLALQTQ RVLLEKRRKA SAWQRNLGYP
LAMLCLLVLT GLSVLIVAIH ILELLIDEAA MPRGMQGASL GQVSFSKLGS FGAVVQVVLI
FYLMVSSVVG FYSSPLFRSL RPRWHDTAMT QIIGNCVCLL VLSSALPVFS RTLGLTRFDL
LGDFGRFNWL GNFYIVFLYN AAFAGLTTLC LVKTFTAAVR AELIRAFGLD RLPLPVSGFP
RASRKTQHQ