ID   LMBRL_XENLA             Reviewed;         483 AA.
AC   Q7ZX75;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Protein LMBR1L;
GN   Name=lmbr1l;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in lymphocyte development by negatively
CC       regulating the canonical Wnt signaling pathway (By similarity). May act
CC       as a LCN1 receptor (By similarity). {ECO:0000250|UniProtKB:Q6UX01,
CC       ECO:0000250|UniProtKB:Q9D1E5}.
CC   -!- SUBUNIT: Dimer (By similarity). Can also form higher oligomers (By
CC       similarity). {ECO:0000250|UniProtKB:Q6UX01}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6UX01};
CC       Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum
CC       membrane {ECO:0000250|UniProtKB:Q6UX01}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the LIMR family. {ECO:0000305}.
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DR   EMBL; BC045132; AAH45132.1; -; mRNA.
DR   RefSeq; NP_001080737.1; NM_001087268.1.
DR   AlphaFoldDB; Q7ZX75; -.
DR   GeneID; 380429; -.
DR   KEGG; xla:380429; -.
DR   CTD; 380429; -.
DR   Xenbase; XB-GENE-5859065; lmbr1l.L.
DR   OrthoDB; 768229at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 380429; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR008075; LIMR.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   PANTHER; PTHR12625; PTHR12625; 1.
DR   Pfam; PF04791; LMBR1; 2.
DR   PRINTS; PR01692; LIPOCALINIMR.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endocytosis; Endoplasmic reticulum; Membrane; Receptor;
KW   Reference proteome; Transmembrane; Transmembrane helix;
KW   Wnt signaling pathway.
FT   CHAIN           1..483
FT                   /note="Protein LMBR1L"
FT                   /id="PRO_0000053914"
FT   TOPO_DOM        1..21
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..112
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..294
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        316..342
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        364..386
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        408..429
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        451..483
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   483 AA;  54229 MW;  40AD9BB154DB4AD5 CRC64;
     MEVNQDVSVR EQIFHDWVRE CIICSLLFST LYLLSYIVIT KFKKHADFAT VDVEDAAVNR
     IALWMCTFTL AVSVGAVLLL PFSIISNEVL LSVPHNYYIQ WLNGSLIHGL WNLVFLFSNL
     SLVFLMPFAY LFTEAEGFAG SKKGVMSRVY ETTVVLLLLT LLVFGIVWVA SAIFDDDSAG
     RESLYDLWEY YLPYLYSGIS LFGVLLLLLC TPFGLSRMFS VTGNLLVKPR LLENLEEHLS
     CTAFEEAAIS RKISTKASCW LNLNMEALQK RLLAIQSHRI TLEMRRRASP WQRNLVYPLA
     MLLLLALTGI TVLIVCVNVL ELLIDEAAMP KGIQGSQLGK VSFSVFGSFG AAVQVILIFY
     LMASSVVGFY SSPLFIQLLP QKQNTPMTKI IGNCVSLLIL SSALPVFSRT LGITRFDLLG
     DFGRFNWLGN FYLILLYNMM FAGLATLCLV KKFTWAVQAE LIRAFGLDRL PLSVKKIRSQ
     GKA