ID   LMCD1_BOVIN             Reviewed;         363 AA.
AC   Q17QE2;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=LIM and cysteine-rich domains protein 1;
GN   Name=LMCD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional cofactor that restricts GATA6 function by
CC       inhibiting DNA-binding, resulting in repression of GATA6
CC       transcriptional activation of downstream target genes. Represses GATA6-
CC       mediated trans activation of lung- and cardiac tissue-specific
CC       promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC
CC       promoter. Plays a critical role in the development of cardiac
CC       hypertrophy via activation of calcineurin/nuclear factor of activated
CC       T-cells signaling pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with beta-dystroglycan. Interacts with GATA1, GATA4
CC       and GATA6 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}.
CC   -!- DOMAIN: The LIM zinc-binding domains and the Cys-rich region mediate
CC       interaction with GATA6. {ECO:0000250}.
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DR   EMBL; BC118414; AAI18415.1; -; mRNA.
DR   RefSeq; NP_001069690.1; NM_001076222.2.
DR   AlphaFoldDB; Q17QE2; -.
DR   SMR; Q17QE2; -.
DR   STRING; 9913.ENSBTAP00000007149; -.
DR   PaxDb; Q17QE2; -.
DR   Ensembl; ENSBTAT00000007149; ENSBTAP00000007149; ENSBTAG00000005431.
DR   GeneID; 540474; -.
DR   KEGG; bta:540474; -.
DR   CTD; 29995; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005431; -.
DR   VGNC; VGNC:30926; LMCD1.
DR   eggNOG; KOG1704; Eukaryota.
DR   GeneTree; ENSGT00940000158813; -.
DR   HOGENOM; CLU_008937_1_0_1; -.
DR   InParanoid; Q17QE2; -.
DR   OMA; MCSGFEP; -.
DR   OrthoDB; 997264at2759; -.
DR   TreeFam; TF313265; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000005431; Expressed in gluteus medius and 99 other tissues.
DR   ExpressionAtlas; Q17QE2; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; ISS:UniProtKB.
DR   GO; GO:0010611; P:regulation of cardiac muscle hypertrophy; ISS:UniProtKB.
DR   CDD; cd09829; PET_testin; 1.
DR   InterPro; IPR010442; PET_domain.
DR   InterPro; IPR033724; PET_testin.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   Pfam; PF06297; PET; 1.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR   PROSITE; PS51303; PET; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; LIM domain; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..363
FT                   /note="LIM and cysteine-rich domains protein 1"
FT                   /id="PRO_0000252665"
FT   DOMAIN          99..206
FT                   /note="PET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00636"
FT   DOMAIN          239..304
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          305..363
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   REGION          200..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         16
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZU5"
SQ   SEQUENCE   363 AA;  40723 MW;  7115263766A64F39 CRC64;
     MAKVAKDLNP RVQKMSLGQQ QSARGVPCLR CKGTCSGFEP HSWRKICKSC KCSQEDHCLS
     SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI MTNPIATGKD PTFDTITYEW
     APPGVTQKLG LQYMELIPKE KQPVTGTEGA LYRRRQLMHQ LPIYDQDPSR CRGLLENELK
     VMEEFVKQYK SEALGVGEVA LPGQGGLPKE EGKQQEKPEG AETAPPTTNG SIGDPSKEYV
     CELCKGVAPA DSPVVYSDRA GYSKQWHPAC FVCAKCSEPL VDLIYFWKDG APWCGRHYCE
     SLRPRCSGCD EIIFSEDYQR VEDLAWHRKH FVCEGCEQQL GGRAYIVTMG QLLCPTCSKS
     KRS