LMCD1_PIG
ID LMCD1_PIG Reviewed; 363 AA.
AC Q5PXT2;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=LIM and cysteine-rich domains protein 1;
GN Name=LMCD1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=16331329; DOI=10.1111/j.1745-7270.2005.00113.x;
RA Wang J., Deng C.Y., Xiong Y.Z., Zuo B., Xing L., Li F.E., Lei M.G.,
RA Zheng R., Jiang S.W.;
RT "cDNA cloning, sequence analysis of the porcine LIM and cysteine-rich
RT domain 1 gene.";
RL Acta Biochim. Biophys. Sin. 37:843-850(2005).
CC -!- FUNCTION: Transcriptional cofactor that restricts GATA6 function by
CC inhibiting DNA-binding, resulting in repression of GATA6
CC transcriptional activation of downstream target genes. Represses GATA6-
CC mediated trans activation of lung- and cardiac tissue-specific
CC promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC
CC promoter. Plays a critical role in the development of cardiac
CC hypertrophy via activation of calcineurin/nuclear factor of activated
CC T-cells signaling pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with beta-dystroglycan. Interacts with GATA1, GATA4
CC and GATA6 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in both skeletal muscle and
CC cardiac muscle. {ECO:0000269|PubMed:16331329}.
CC -!- DOMAIN: The LIM zinc-binding domains and the Cys-rich region mediate
CC interaction with GATA6. {ECO:0000250}.
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DR EMBL; AY821789; AAV70654.1; -; mRNA.
DR RefSeq; NP_001008692.1; NM_001008692.1.
DR AlphaFoldDB; Q5PXT2; -.
DR STRING; 9823.ENSSSCP00000012297; -.
DR PaxDb; Q5PXT2; -.
DR PeptideAtlas; Q5PXT2; -.
DR Ensembl; ENSSSCT00000012628; ENSSSCP00000012297; ENSSSCG00000011538.
DR Ensembl; ENSSSCT00005064392; ENSSSCP00005039795; ENSSSCG00005040226.
DR Ensembl; ENSSSCT00015051691; ENSSSCP00015020610; ENSSSCG00015038849.
DR Ensembl; ENSSSCT00025010180; ENSSSCP00025004069; ENSSSCG00025007594.
DR Ensembl; ENSSSCT00030057456; ENSSSCP00030026092; ENSSSCG00030041369.
DR Ensembl; ENSSSCT00035031849; ENSSSCP00035012509; ENSSSCG00035024215.
DR Ensembl; ENSSSCT00040045681; ENSSSCP00040019153; ENSSSCG00040033943.
DR Ensembl; ENSSSCT00045029952; ENSSSCP00045020760; ENSSSCG00045017376.
DR Ensembl; ENSSSCT00050033057; ENSSSCP00050013768; ENSSSCG00050024517.
DR Ensembl; ENSSSCT00055060507; ENSSSCP00055048470; ENSSSCG00055030407.
DR Ensembl; ENSSSCT00060068489; ENSSSCP00060029431; ENSSSCG00060050314.
DR Ensembl; ENSSSCT00065061058; ENSSSCP00065026445; ENSSSCG00065044614.
DR Ensembl; ENSSSCT00070041799; ENSSSCP00070035102; ENSSSCG00070021039.
DR GeneID; 494020; -.
DR KEGG; ssc:494020; -.
DR CTD; 29995; -.
DR VGNC; VGNC:89756; LMCD1.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00940000158813; -.
DR HOGENOM; CLU_008937_1_0_1; -.
DR InParanoid; Q5PXT2; -.
DR OMA; MCSGFEP; -.
DR OrthoDB; 997264at2759; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Proteomes; UP000314985; Chromosome 13.
DR Bgee; ENSSSCG00000011538; Expressed in psoas major muscle and 45 other tissues.
DR ExpressionAtlas; Q5PXT2; baseline and differential.
DR Genevisible; Q5PXT2; SS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; ISS:UniProtKB.
DR GO; GO:0010611; P:regulation of cardiac muscle hypertrophy; ISS:UniProtKB.
DR CDD; cd09829; PET_testin; 1.
DR InterPro; IPR010442; PET_domain.
DR InterPro; IPR033724; PET_testin.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF06297; PET; 1.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS51303; PET; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; LIM domain; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..363
FT /note="LIM and cysteine-rich domains protein 1"
FT /id="PRO_0000265102"
FT DOMAIN 99..206
FT /note="PET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00636"
FT DOMAIN 239..304
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 305..363
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REGION 200..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZU5"
SQ SEQUENCE 363 AA; 40660 MW; 2E9A904ACD584A68 CRC64;
MAKVAKDLNP GVQKMSLGQQ QSARGVPCLR CKGTCSGFEP HSWRKICKSC KCSQEDHFLS
SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI MTNPIATGKD PTFDTITYEW
APPGVTQKLG LQYMELIPKE KQPVTGTEGA YYRRRQLMHQ LPIYDQDPSR CRGLLESELK
VMEEFVKQYK SEALGVGEVA LPGQGGLPKE EGKQQEKPEG AETAAPTANG SLGDPSKEYV
CELCKGVAPA DSPVVYSDRA GYSKQWHPAC FVCAKCSEPL VDLIYFWKDG APWCGRHYCE
SLRPRCSGCD EIIFSEDYQR VEDLAWHRKH FVCEGCEQQL GGRAYIITKG QLLCPTCSKS
KRT
