ID   LMCSN_LUMTE             Reviewed;          11 AA.
AC   C0HLK7;
DT   31-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   31-JUL-2019, sequence version 1.
DT   02-JUN-2021, entry version 4.
DE   RecName: Full=Lumbricusin {ECO:0000303|PubMed:24796676};
OS   Lumbricus terrestris (Common earthworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Oligochaeta; Crassiclitellata; Lumbricina; Lumbricidae; Lumbricinae;
OC   Lumbricus.
OX   NCBI_TaxID=6398;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND SYNTHESIS.
RX   PubMed=24796676; DOI=10.1016/j.bbrc.2014.04.105;
RA   Kim D.H., Lee I.H., Nam S.T., Hong J., Zhang P., Hwang J.S., Seok H.,
RA   Choi H., Lee D.G., Kim J.I., Kim H.;
RT   "Neurotropic and neuroprotective activities of the earthworm peptide
RT   Lumbricusin.";
RL   Biochem. Biophys. Res. Commun. 448:292-297(2014).
RN   [2] {ECO:0000305}
RP   SYNTHESIS.
RX   PubMed=26215270; DOI=10.4014/jmb.1507.07011;
RA   Kim D.H., Lee I.H., Nam S.T., Hong J., Zhang P., Lu L.F., Hwang J.S.,
RA   Park K.C., Kim H.;
RT   "Antimicrobial peptide, Lumbricusin, ameliorates motor dysfunction and
RT   dopaminergic neurodegeneration in a mouse model of Parkinson's Disease.";
RL   J. Microbiol. Biotechnol. 25:1640-1647(2015).
CC   -!- MISCELLANEOUS: Induces proliferation of human neuroblastoma cells but
CC       not of human colonic epithelial cells or human adrenal carcinoma cells
CC       (PubMed:24796676). Also increases proliferation of mouse neural stem
CC       cells (PubMed:26215270). In human neuroblastoma cells and mouse neural
CC       stem cells, inhibits apoptosis induced by the synthetic neurotoxic
CC       compound 6-hydroxydopamine (6-OHDA) (PubMed:24796676). In human
CC       neuroblastoma cells and mouse neural stem cells, increases
CC       ubiquitination of cyclin-dependent kinase inhibitor CDKN1B, promoting
CC       its degradation (PubMed:24796676, PubMed:26215270). Attenuates motor
CC       impairments in 6-OHDA-treated mice (PubMed:26215270).
CC       {ECO:0000269|PubMed:24796676, ECO:0000269|PubMed:26215270}.
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PE   1: Evidence at protein level;
KW   Direct protein sequencing.
FT   PEPTIDE         1..11
FT                   /note="Lumbricusin"
FT                   /evidence="ECO:0000269|PubMed:24796676"
FT                   /id="PRO_0000447646"
SQ   SEQUENCE   11 AA;  1446 MW;  70007740A05EA364 CRC64;
     RNRRWCIDQQ A