LMD2B_DICDI
ID LMD2B_DICDI Reviewed; 790 AA.
AC Q54TM2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=LMBR1 domain-containing protein 2 homolog B;
GN ORFNames=DDB_G0281669;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LIMR family. {ECO:0000305}.
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DR EMBL; AAFI02000042; EAL66596.1; -; Genomic_DNA.
DR RefSeq; XP_640569.1; XM_635477.1.
DR AlphaFoldDB; Q54TM2; -.
DR SMR; Q54TM2; -.
DR STRING; 44689.DDB0204597; -.
DR PaxDb; Q54TM2; -.
DR EnsemblProtists; EAL66596; EAL66596; DDB_G0281669.
DR GeneID; 8623178; -.
DR KEGG; ddi:DDB_G0281669; -.
DR dictyBase; DDB_G0281669; lmbd2B.
DR eggNOG; KOG2296; Eukaryota.
DR HOGENOM; CLU_355438_0_0_1; -.
DR InParanoid; Q54TM2; -.
DR OMA; KYTSYVM; -.
DR PhylomeDB; Q54TM2; -.
DR PRO; PR:Q54TM2; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0071944; C:cell periphery; IDA:dictyBase.
DR GO; GO:0031941; C:filamentous actin; IDA:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR GO; GO:0001726; C:ruffle; IDA:dictyBase.
DR GO; GO:0016477; P:cell migration; IMP:dictyBase.
DR GO; GO:0006935; P:chemotaxis; IMP:dictyBase.
DR GO; GO:0006897; P:endocytosis; IEP:dictyBase.
DR GO; GO:0031268; P:pseudopodium organization; IMP:dictyBase.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..790
FT /note="LMBR1 domain-containing protein 2 homolog B"
FT /id="PRO_0000339414"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 539..559
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 236..266
FT /evidence="ECO:0000255"
SQ SEQUENCE 790 AA; 88926 MW; D5C67FDB060FD803 CRC64;
MSSNTTTPTP TSTPTPTSSP SIGPVPIPYE SASFGNLLFF AISLVLCGVV VLIGMKQYIS
LKRTPIYATF FSFLGWFMCF SIAYLVPLDI IVTDHLQCVI ENNETLTGEC EIPVTYLPYG
MITQQWRFLY FGSLILCWVI FPVLQSFSTA GDFRFWERVK RATKENVILY TFMFIAGLIG
IIVILSVKEM DPSSFLSFVM LLANVYGVIL ITITMGYGLI DVPRNLLRKG SHYAILRNYR
VEAVVLKTEL EDVKRQLIDH LKLIKTISDR AGQYDPFRIY LDVIISKCPT EYDVLIQEYH
AEPLPAGMEA EILSYKYLVG IHSTLLDLVD RNHSAEVLYE RLLGKAFAIE DIIETRERNK
QTAGNNQIAG EERSIQWSFK STKSNGKFEY LWHMYIHPWY FIIAGLVCVC LSGIILWSEI
VLALVSNPDY SPFYRAIVRM EPGIGLQIFC FIPMIYMCVC SYSTLFKLRI SNYYRLVPQQ
SNTFSIMFSA NYLCRLAAPL AYNFIQICHV NQDNSIVSPF SKIMGDMNAF GDNALGKRFT
LFFPIFMIVV CVISFFNLHK RLAGSCCIRS LRIVTDTSEG AVDHGLKILK QEREERSLTG
GVAPVKTRMS IVKEMFTKKK GAGILVTDNS QLDGASGAHR EPSIDSSNRY KPTPTKTSIN
IPKLSRTYTS AAGNVYSSTQ DGDENSNSGI KPINSFFSSI LGEKGNASNN NNNNNNNNNN
NNSNNKNSNN NNNSILTSNY ESYSTPRTKD KQGLLSSALD KMDFSFQDDD DHTFDDIEMG
AYGTGRKNKK
