ID   LMF1_BOVIN              Reviewed;         561 AA.
AC   Q0P5C0;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Lipase maturation factor 1;
DE   AltName: Full=Transmembrane protein 112;
GN   Name=LMF1; Synonyms=TMEM112;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the maturation of specific proteins in the
CC       endoplasmic reticulum. Required for maturation and transport of active
CC       lipoprotein lipase (LPL) through the secretory pathway. Each LMF1
CC       molecule chaperones 50 or more molecules of LPL (By similarity).
CC       {ECO:0000250|UniProtKB:Q3U3R4, ECO:0000250|UniProtKB:Q96S06}.
CC   -!- SUBUNIT: Interacts with LPL and SEL1L. {ECO:0000250|UniProtKB:Q3U3R4}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q3U3R4}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q3U3R4}.
CC   -!- SIMILARITY: Belongs to the lipase maturation factor family.
CC       {ECO:0000305}.
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DR   EMBL; BC120253; AAI20254.1; -; mRNA.
DR   RefSeq; NP_001068658.1; NM_001075190.2.
DR   AlphaFoldDB; Q0P5C0; -.
DR   STRING; 9913.ENSBTAP00000004206; -.
DR   PaxDb; Q0P5C0; -.
DR   GeneID; 505124; -.
DR   KEGG; bta:505124; -.
DR   CTD; 64788; -.
DR   eggNOG; ENOG502QT4H; Eukaryota.
DR   HOGENOM; CLU_020557_2_0_1; -.
DR   InParanoid; Q0P5C0; -.
DR   OrthoDB; 759759at2759; -.
DR   TreeFam; TF314339; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051604; P:protein maturation; IBA:GO_Central.
DR   GO; GO:0006641; P:triglyceride metabolic process; ISS:UniProtKB.
DR   InterPro; IPR009613; LMF.
DR   PANTHER; PTHR14463; PTHR14463; 1.
DR   Pfam; PF06762; LMF1; 2.
PE   2: Evidence at transcript level;
KW   Chaperone; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..561
FT                   /note="Lipase maturation factor 1"
FT                   /id="PRO_0000276738"
FT   TOPO_DOM        1..42
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..120
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        145..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        215..285
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        315..360
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        383..561
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   561 AA;  64022 MW;  763BD4CF7C2A473D CRC64;
     MAAPRESLRR RKAGAGDPEP EAPPGQGRDL KGRPARLRAG TFWLTRIVLL RALAFVYFVA
     FLVAFHQNKQ LIGDRGLLPC RAYLQSVQRH FGGRVSWDAL SYAPTILWLL DWSHMDANLD
     ALALLGLGIS SFILVSGCAN MVLMAALWVL YMSLVNVGQI WYSFGWESQL LETGFLGIFL
     CPLWTLSALP RGTPTSWVVM WGFRWLIFRI MLGAGLIKIR GDRCWRDLTC MDFHYETQPV
     PNPVAYFLHR SPWWFHRFET LSNHFLELVV PFFIFLGRRM CIVHGALQVL FQVVLIISGN
     LSFLNWLTIV PSLACFDDAT LGGLFPSGPG RLKDQVLKIQ EEETRGARAP RTRGSVARGT
     VNLALGILVA WLSIPVVLNL LSPRQVMNSS FNPLRIVNTY GAFGSITRER TEVILQGTAS
     ANASAPDSAW EDYEFKCKPG DPRRRPCLIS PYHHRLDWLM WFAAFQTYEH NEWIIHLAGK
     LLANDAQALS LLARNPFEGR DPPRWVRGEH YRYKFSRPGG RHAAEGKWWI RRRLGPYFPP
     LSRQDLRGYF TSRQWPYPEP E