LMF2_BOVIN
ID LMF2_BOVIN Reviewed; 703 AA.
AC A1L504; Q32PH4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Lipase maturation factor 2;
GN Name=LMF2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the maturation of specific proteins in the
CC endoplasmic reticulum. May be required for maturation and transport of
CC active lipoprotein lipase (LPL) through the secretory pathway (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A1L504-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1L504-2; Sequence=VSP_032252, VSP_032253;
CC -!- SIMILARITY: Belongs to the lipase maturation factor family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABM06059.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BT029791; ABM06059.1; ALT_FRAME; mRNA.
DR EMBL; BC108115; AAI08116.1; -; mRNA.
DR RefSeq; NP_001032532.1; NM_001037455.1.
DR AlphaFoldDB; A1L504; -.
DR STRING; 9913.ENSBTAP00000050413; -.
DR PaxDb; A1L504; -.
DR GeneID; 510646; -.
DR KEGG; bta:510646; -.
DR CTD; 91289; -.
DR eggNOG; ENOG502QTN6; Eukaryota.
DR InParanoid; A1L504; -.
DR OrthoDB; 759759at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051604; P:protein maturation; IBA:GO_Central.
DR InterPro; IPR009613; LMF.
DR PANTHER; PTHR14463; PTHR14463; 1.
DR Pfam; PF06762; LMF1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..703
FT /note="Lipase maturation factor 2"
FT /id="PRO_0000324509"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 637..657
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 660..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 489
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..31
FT /note="MAGSRVPRQLFLQGVAAVFMFAFASLYTQIP -> MCPPT (in isoform
FT 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_032252"
FT VAR_SEQ 536..703
FT /note="VIRLVQNHVPSYPFHQQPPTYVRAQLYKYWFSHPWEQGQWWRRQWVEEFFPS
FT VSLGDPALDMLLRQFGLQDKSPPRAGGSSNTLSQALHWVRKQLSPLEAPALLWGLLGAV
FT GAIKVMQALLGPQSLPRTKEEKHKPAPQEDSVAASKQASPAPNISSGSQTPRRKKSP
FT -> ATHIRAGPALQVLVLAPLGAGPMVATPVGGRILPIRVPGGPGAGHAAQAVWPSGQK
FT PAPGRWLQQHPEPGSPLGTETAVSPGGPRPALGAPGGCGGHQGHAGPAGPAVPASDQGG
FT EAQASPPGGLGSCQQASFPSPQHQQRLPDPPAEKVAVICQPHVLRGSGSRLPLALCHRR
FT AQPPCLSQLPCRRRSGCWPVGGASPSASRASPHPHHVRSQDTLQ (in isoform
FT 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_032253"
FT CONFLICT 77
FT /note="G -> D (in Ref. 2; AAI08116)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="H -> R (in Ref. 2; AAI08116)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="V -> M (in Ref. 2; AAI08116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 703 AA; 79266 MW; 9ED680EE67242F52 CRC64;
MAGSRVPRQL FLQGVAAVFM FAFASLYTQI PGLYGPEGIL PARRTLRPQG KGRWQQLWET
PTLLWEAPLL GLDTAQGLEL LSLLGTVLAL GALLTRQLHH PLVYLLLWAA YLSVCQVGQV
FLYFQWDSLL LETGFLAMLV APLGLPPNHK QAPQGRPGGV SPHEGLPFWL VRWLLFRLMF
ASGVVKLTSR CPAWWGLTAL TYHYETQCLP TPAAWFAHHL PVWLHKLSVV ATFLIEIAVP
PLFFAPVRRL RLAAFYSQVL LQVLIILTGN YNFFNLLTLV LTTALLDDTH LAAKSSTSRR
KRMPSSWPKA LLAMLTLLLE LAVYGLLACG VVHYFGLEVD WEQHVVRSRT MFTFHQLSQW
LKTVTLPTMW LGAASLAWEL LTALWRWVQV RGSLRKLCAA VQLSVFGTAT VALFLISLVP
YSYMEPSSHG RLWTGAHRLF STVEHLQLAN SYGLFRRMTG LGGRPEVVLE GSYDGHQWTE
IEFMYKPGNL SRPPPIVVPH QPRLDWQMWF AALGPHTHSP WFTSLVLRLL QGKEPVIRLV
QNHVPSYPFH QQPPTYVRAQ LYKYWFSHPW EQGQWWRRQW VEEFFPSVSL GDPALDMLLR
QFGLQDKSPP RAGGSSNTLS QALHWVRKQL SPLEAPALLW GLLGAVGAIK VMQALLGPQS
LPRTKEEKHK PAPQEDSVAA SKQASPAPNI SSGSQTPRRK KSP
