ID   LMF2_CHICK              Reviewed;         714 AA.
AC   Q5ZKZ9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Lipase maturation factor 2;
GN   Name=LMF2; ORFNames=RCJMB04_8i13;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Involved in the maturation of specific proteins in the
CC       endoplasmic reticulum. May be required for maturation and transport of
CC       active lipoprotein lipase (LPL) through the secretory pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lipase maturation factor family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG31594.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ719935; CAG31594.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001026743.1; NM_001031572.1.
DR   AlphaFoldDB; Q5ZKZ9; -.
DR   STRING; 9031.ENSGALP00000039613; -.
DR   PaxDb; Q5ZKZ9; -.
DR   GeneID; 429380; -.
DR   KEGG; gga:429380; -.
DR   CTD; 91289; -.
DR   VEuPathDB; HostDB:geneid_429380; -.
DR   eggNOG; ENOG502QTN6; Eukaryota.
DR   InParanoid; Q5ZKZ9; -.
DR   PhylomeDB; Q5ZKZ9; -.
DR   PRO; PR:Q5ZKZ9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051604; P:protein maturation; IBA:GO_Central.
DR   InterPro; IPR009613; LMF.
DR   PANTHER; PTHR14463; PTHR14463; 1.
DR   Pfam; PF06762; LMF1; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..714
FT                   /note="Lipase maturation factor 2"
FT                   /id="PRO_0000324513"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        398..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        629..649
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          654..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..714
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        483
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   714 AA;  81566 MW;  35DDB08A87F2BCA2 CRC64;
     MGEPPRRPRE LFLAGLAAAY LAAFVSLYLQ IPGLYGRDGI LPARRVLRLS GKGLWEQLRD
     VPTLLWLGPQ LGLDTEQGME LLCLLGAVAS MGALLCAPLR DCLLFAVLRV FYLSLYQVGQ
     VFLYFQWDSL LLEAGFLAVL VAPLRLFKWR STAWRPHDSV TFWLVRWLLF RLMFASGVVK
     LTSRCPTWWG LTALTYHYET QCIPTPAAWY AHQLPVWFQK FSVVATYVIE IAVPLLFFMP
     IRRLRLFAFY CQVLLQILII LTGNYNFFNA LTIVLAFSLL DEEHMGRWMG RGKRKHGSSA
     WPPTLLSFLS TLLELATYAL LLYWSVHYFS LEIDWEKGLL ESKVAFTYHE FTQWLRAVTL
     PLVGLGFLSL SWEILSALYR CACVRGFFWK LWATLQWAVF ATATVGMFAI SLVPFTYIDY
     ESNGKLWPGI HQMFSAVERF QVVNSYGLFR RMTGVGGRPE VVLEGSYDKQ SWTEIEFMYK
     PGNVSAAPAV VAPHQPRLDW QMWFAALAHH SSSPWFASFV HRLLQGKEDV IRLVQVDEDK
     YPFSTQPPVY LRAQLYKYWF THSAESGAGA AQWWRRQHVQ EFFPTVSVGD PTLDGLLAQH
     GLKDKLPLKR PVDAFLPWLL SSVRQLSRPF SPHVVLWSLY VVAATTCLLR AMARRPRGGA
     PPTRHKAPKQ PRGDQGEKNG QLRRKEGREA EERGEGRSRG AADGEGPRGT KRRK