ID   LMF2_XENLA              Reviewed;         707 AA.
AC   Q7ZWN0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Lipase maturation factor 2;
GN   Name=lmf2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the maturation of specific proteins in the
CC       endoplasmic reticulum. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lipase maturation factor family.
CC       {ECO:0000305}.
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DR   EMBL; BC046869; AAH46869.1; -; mRNA.
DR   RefSeq; NP_001079679.1; NM_001086210.1.
DR   AlphaFoldDB; Q7ZWN0; -.
DR   DNASU; 379366; -.
DR   GeneID; 379366; -.
DR   KEGG; xla:379366; -.
DR   CTD; 379366; -.
DR   Xenbase; XB-GENE-974445; lmf2.L.
DR   OrthoDB; 759759at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 379366; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR   InterPro; IPR009613; LMF.
DR   PANTHER; PTHR14463; PTHR14463; 1.
DR   Pfam; PF06762; LMF1; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..707
FT                   /note="Lipase maturation factor 2"
FT                   /id="PRO_0000324514"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        634..654
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          661..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..694
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        483
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   707 AA;  82267 MW;  B37A31482CF5CB92 CRC64;
     MGEHRLARSA FLWGLSGIYL FAFVSLYVQI PGLYGREGIL PAWKMLRFTG KGFWEQMKDS
     PSLLWFGPRL GLDTEMTMEL ICLLGALLSL GALLFSCLRD SLVFLLLWVF YLSLYQVGQV
     FLYFQWDSLL LETGFLAILV APLHAMRWKT SVWSAHDGVT FWLTRWLLFR LMFASGVVKL
     TSRCPTWWGL TALTYHYETQ CIPNPAAWYA HQLPVWLQKF SVVATFFIEI GVPWLFFLPF
     RRLRLFSFYS QVLLQILIII TGNYNFFNLL TIVLCCSMLD DQHIAFFQRH KKTQHKGGIA
     TSAFSLRSLV SLLEIPIFGL LVFWTVKYFD LQINWDKHSL ESRTAFTYHD FQQWLRTITF
     PSIWIAAASL GWEILKGMYR SASVRGFFWK LWSTLQWLMF SCAAAAMFTI SLVPYTYMDF
     ESNGQLWPEV HQMFNTVDRY QLVNSYGLFR RMTGVGGRPE VVVEGSFDRE TWTEIEFMYK
     PGNISTIPTV IVPHQPRLDW QMWFAALSHH SHSPWFASFV YRLLQGNKDV IHLVQNDESL
     YPFHANPPTY IRAQQYKYWF TEVDQSGHMP KSWWRRRHVE EFFPAVFLDD PFLDNLLSQH
     GLKDKPPARR SLDAPIPFVL KLIRDFLHPL PAPLLLHSFI FGIFTIYFLQ AMFGGVSRPS
     VAKQRHSMPP NEKKKQKPNS GQGESASSKS SGHGTDTVRR NKKNEKS