ID   LMN1_HYPDU              Reviewed;         646 AA.
AC   A0A125S9M4;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Lamin-1 {ECO:0000303|PubMed:26840051};
OS   Hypsibius dujardini (Water bear) (Macrobiotus dujardini).
OC   Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC   Hypsibioidea; Hypsibiidae; Hypsibius.
OX   NCBI_TaxID=232323;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION, SUBCELLULAR LOCATION, AND
RP   DOMAIN.
RX   PubMed=26840051; DOI=10.7554/elife.11117;
RA   Hering L., Bouameur J.E., Reichelt J., Magin T.M., Mayer G.;
RT   "Novel origin of lamin-derived cytoplasmic intermediate filaments in
RT   tardigrades.";
RL   Elife 5:E11117-E11117(2016).
CC   -!- FUNCTION: Intermediate filament (IF) protein, component of the nuclear
CC       lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear
CC       membrane, which is thought to provide a framework for the nuclear
CC       envelope (PubMed:26840051). {ECO:0000305|PubMed:26840051}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26840051}.
CC       Note=Localizes throughout the nucleoplasm (PubMed:26840051).
CC       {ECO:0000269|PubMed:26840051}.
CC   -!- DOMAIN: Contains an alpha-helical IF rod domain organization with three
CC       coiled coil-forming segments (coil 1A, coil 1B, and coil 2)
CC       (PubMed:26840051). {ECO:0000305|PubMed:26840051}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; KU295460; AME17870.1; -; mRNA.
DR   AlphaFoldDB; A0A125S9M4; -.
DR   SMR; A0A125S9M4; -.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.1260; -; 1.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   InterPro; IPR036415; Lamin_tail_dom_sf.
DR   Pfam; PF00038; Filament; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF74853; SSF74853; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Nucleus.
FT   CHAIN           1..646
FT                   /note="Lamin-1"
FT                   /id="PRO_0000440214"
FT   DOMAIN          90..446
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188,
FT                   ECO:0000305|PubMed:26840051"
FT   DOMAIN          504..618
FT                   /note="LTD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT   REGION          1..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1..85
FT                   /note="Head"
FT                   /evidence="ECO:0000305|PubMed:26840051"
FT   REGION          86..126
FT                   /note="Coil 1A"
FT                   /evidence="ECO:0000305|PubMed:26840051"
FT   REGION          127..137
FT                   /note="Linker 1"
FT                   /evidence="ECO:0000305|PubMed:26840051"
FT   REGION          138..281
FT                   /note="Coil 1B"
FT                   /evidence="ECO:0000305|PubMed:26840051"
FT   REGION          281..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          282..299
FT                   /note="Linker 2"
FT                   /evidence="ECO:0000305|PubMed:26840051"
FT   REGION          300..439
FT                   /note="Coil 2"
FT                   /evidence="ECO:0000305|PubMed:26840051"
FT   REGION          440..646
FT                   /note="Tail"
FT                   /evidence="ECO:0000305|PubMed:26840051"
FT   REGION          476..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           457..471
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000305|PubMed:26840051"
FT   COMPBIAS        40..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..303
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..512
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   646 AA;  71615 MW;  E73574EF4F02AC92 CRC64;
     MAEKAGEAGV QTRSRRNRST SREVSNGVAA PPAKATRSSQ LEAVAEQATP SSQQSQKSVR
     TESSMSLGFN GGSSQGSRAT SPTSFSRAQE KEELQNLNDR LAKILNKLND SEEENRTLKI
     RLTTVQQETS ADLNDQIGKY RDELERARKA VDAITQEKDR ELLAKDKALG ELNEHKAQFA
     ALRKRLDELE ARLKAAEKAA RDKDNVLTEL KAQLAESETA GKRIQKELAD KTKQLDQARN
     QIEQEVISRT NLENALKTAE EKAKFENNLL ESKLQRQSLS VTTVDHHSAQ STSRRSGSDF
     SASVEDMRSA LEDAREEIQE NMDRMYGSKL EGLEVLSESQ KQTINGLNQA LTASRHDMKD
     LQKENQQLRK KVGEVEKELH QQHQKFDQHK MDCTARIAAL SDQSNQASQQ YQALLEEYRT
     TTHNNVEMRT ELEMYNKLLS DEEIRLGITS ADQYGGVRHG AKKRKLTETF YTTPFGSRSS
     AGSRSAGHNS TPVTKSQVTR TTVKTSENKS KASGPVRILE VAPGKVVRLE NISEAVMQLG
     HWRIHQHGAS GDAAFQFEKD QVIGGQSIIS VYSSTEDSQP NNGVTEIIAT NAWLADSHLE
     TVLSDGDGNQ MATYEVSADS NLDIHNDSVR DSPRSAGKGI LGFFGL