LMO3_HUMAN
ID LMO3_HUMAN Reviewed; 145 AA.
AC Q8TAP4; B4DG90; B4DH35; Q58A66; Q58A67; Q8N974; Q9UDD5;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=LIM domain only protein 3;
DE Short=LMO-3;
DE AltName: Full=Neuronal-specific transcription factor DAT1;
DE AltName: Full=Rhombotin-3;
GN Name=LMO3; Synonyms=RBTN3, RBTNL2, RHOM3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
RA Nakagawara A., Inuzuka H., Ohira M., Shishikura T., Morohashi A., Kuma H.,
RA Nozawa I.;
RT "The gene expressed in primary neuroblastoma.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
RC TISSUE=Amygdala, and Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-69.
RC TISSUE=Brain;
RX PubMed=1507224; DOI=10.1016/0022-2836(92)90630-3;
RA Foroni L., Boehm T., White L., Forster A., Sherrington P., Liao X.B.,
RA Brannan C.I., Jenkins N.A., Copeland N.G., Rabbitts T.H.;
RT "The rhombotin gene family encode related LIM-domain proteins whose
RT differing expression suggests multiple roles in mouse development.";
RL J. Mol. Biol. 226:747-761(1992).
CC -!- INTERACTION:
CC Q8TAP4; Q8N9N5: BANP; NbExp=3; IntAct=EBI-742259, EBI-744695;
CC Q8TAP4; Q8NA61: CBY2; NbExp=3; IntAct=EBI-742259, EBI-741724;
CC Q8TAP4; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-742259, EBI-10181988;
CC Q8TAP4; Q96AQ9: FAM131C; NbExp=3; IntAct=EBI-742259, EBI-741921;
CC Q8TAP4; Q8WUP2: FBLIM1; NbExp=5; IntAct=EBI-742259, EBI-3864120;
CC Q8TAP4; Q6FG41: FOS; NbExp=3; IntAct=EBI-742259, EBI-10198738;
CC Q8TAP4; Q13422: IKZF1; NbExp=3; IntAct=EBI-742259, EBI-745305;
CC Q8TAP4; Q719H9: KCTD1; NbExp=3; IntAct=EBI-742259, EBI-9027502;
CC Q8TAP4; Q86Y26: NUTM1; NbExp=3; IntAct=EBI-742259, EBI-10178410;
CC Q8TAP4; Q8N6K7: SAMD3; NbExp=3; IntAct=EBI-742259, EBI-748741;
CC Q8TAP4; Q02446: SP4; NbExp=3; IntAct=EBI-742259, EBI-10198587;
CC Q8TAP4; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-742259, EBI-529518;
CC Q8TAP4-4; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-11742507, EBI-11096309;
CC Q8TAP4-4; Q15027: ACAP1; NbExp=3; IntAct=EBI-11742507, EBI-751746;
CC Q8TAP4-4; Q9NPJ3: ACOT13; NbExp=3; IntAct=EBI-11742507, EBI-1045357;
CC Q8TAP4-4; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-11742507, EBI-19125216;
CC Q8TAP4-4; Q9Y2J4: AMOTL2; NbExp=3; IntAct=EBI-11742507, EBI-746752;
CC Q8TAP4-4; Q8IWZ3-3: ANKHD1; NbExp=3; IntAct=EBI-11742507, EBI-25833200;
CC Q8TAP4-4; O43307: ARHGEF9; NbExp=3; IntAct=EBI-11742507, EBI-3447299;
CC Q8TAP4-4; Q66PJ3-4: ARL6IP4; NbExp=3; IntAct=EBI-11742507, EBI-5280499;
CC Q8TAP4-4; Q9Y576: ASB1; NbExp=3; IntAct=EBI-11742507, EBI-2323092;
CC Q8TAP4-4; Q5T686: AVPI1; NbExp=3; IntAct=EBI-11742507, EBI-8640233;
CC Q8TAP4-4; Q14032: BAAT; NbExp=3; IntAct=EBI-11742507, EBI-8994378;
CC Q8TAP4-4; Q13072: BAGE; NbExp=3; IntAct=EBI-11742507, EBI-25884811;
CC Q8TAP4-4; Q8N9N5-2: BANP; NbExp=6; IntAct=EBI-11742507, EBI-11524452;
CC Q8TAP4-4; O75934: BCAS2; NbExp=5; IntAct=EBI-11742507, EBI-1050106;
CC Q8TAP4-4; Q7L4P6: BEND5; NbExp=3; IntAct=EBI-11742507, EBI-724373;
CC Q8TAP4-4; Q8N7W2-2: BEND7; NbExp=7; IntAct=EBI-11742507, EBI-10181188;
CC Q8TAP4-4; O14503: BHLHE40; NbExp=3; IntAct=EBI-11742507, EBI-711810;
CC Q8TAP4-4; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-11742507, EBI-2548012;
CC Q8TAP4-4; Q6PH81: C16orf87; NbExp=3; IntAct=EBI-11742507, EBI-6598617;
CC Q8TAP4-4; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-11742507, EBI-11976299;
CC Q8TAP4-4; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-11742507, EBI-11530605;
CC Q8TAP4-4; Q96HJ3-2: CCDC34; NbExp=3; IntAct=EBI-11742507, EBI-17641690;
CC Q8TAP4-4; Q96A33: CCDC47; NbExp=3; IntAct=EBI-11742507, EBI-720151;
CC Q8TAP4-4; Q96LY2-2: CCDC74B; NbExp=3; IntAct=EBI-11742507, EBI-17967022;
CC Q8TAP4-4; Q9GZT6: CCDC90B; NbExp=3; IntAct=EBI-11742507, EBI-713148;
CC Q8TAP4-4; Q9C0I3-2: CCSER1; NbExp=3; IntAct=EBI-11742507, EBI-17793327;
CC Q8TAP4-4; Q8N8U2: CDYL2; NbExp=3; IntAct=EBI-11742507, EBI-8467076;
CC Q8TAP4-4; Q7Z7K6: CENPV; NbExp=3; IntAct=EBI-11742507, EBI-1210604;
CC Q8TAP4-4; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-11742507, EBI-11752486;
CC Q8TAP4-4; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-11742507, EBI-742887;
CC Q8TAP4-4; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-11742507, EBI-743375;
CC Q8TAP4-4; Q99828: CIB1; NbExp=3; IntAct=EBI-11742507, EBI-372594;
CC Q8TAP4-4; P15169: CPN1; NbExp=3; IntAct=EBI-11742507, EBI-2116369;
CC Q8TAP4-4; P43234: CTSO; NbExp=3; IntAct=EBI-11742507, EBI-2874283;
CC Q8TAP4-4; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11742507, EBI-3867333;
CC Q8TAP4-4; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-11742507, EBI-10303987;
CC Q8TAP4-4; O95424: DEXI; NbExp=3; IntAct=EBI-11742507, EBI-724515;
CC Q8TAP4-4; O43598: DNPH1; NbExp=3; IntAct=EBI-11742507, EBI-748674;
CC Q8TAP4-4; P21728: DRD1; NbExp=3; IntAct=EBI-11742507, EBI-6624459;
CC Q8TAP4-4; P60228: EIF3E; NbExp=3; IntAct=EBI-11742507, EBI-347740;
CC Q8TAP4-4; Q96J88-3: EPSTI1; NbExp=3; IntAct=EBI-11742507, EBI-25885343;
CC Q8TAP4-4; Q8WUP2: FBLIM1; NbExp=3; IntAct=EBI-11742507, EBI-3864120;
CC Q8TAP4-4; Q8IVH2-2: FOXP4; NbExp=3; IntAct=EBI-11742507, EBI-25885364;
CC Q8TAP4-4; Q96NE9-2: FRMD6; NbExp=3; IntAct=EBI-11742507, EBI-13213391;
CC Q8TAP4-4; O14926: FSCN2; NbExp=3; IntAct=EBI-11742507, EBI-21017948;
CC Q8TAP4-4; Q06547-2: GABPB1; NbExp=3; IntAct=EBI-11742507, EBI-618189;
CC Q8TAP4-4; Q06547-3: GABPB1; NbExp=3; IntAct=EBI-11742507, EBI-9088619;
CC Q8TAP4-4; P19440-3: GGT1; NbExp=3; IntAct=EBI-11742507, EBI-21558069;
CC Q8TAP4-4; Q9UKD1: GMEB2; NbExp=3; IntAct=EBI-11742507, EBI-948296;
CC Q8TAP4-4; O95837: GNA14; NbExp=3; IntAct=EBI-11742507, EBI-7951023;
CC Q8TAP4-4; Q96F32: GNB5; NbExp=3; IntAct=EBI-11742507, EBI-25902214;
CC Q8TAP4-4; Q08379: GOLGA2; NbExp=5; IntAct=EBI-11742507, EBI-618309;
CC Q8TAP4-4; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11742507, EBI-5916454;
CC Q8TAP4-4; O43292-2: GPAA1; NbExp=3; IntAct=EBI-11742507, EBI-25884370;
CC Q8TAP4-4; Q9NWQ4-1: GPATCH2L; NbExp=6; IntAct=EBI-11742507, EBI-11959863;
CC Q8TAP4-4; Q9UJ42: GPR160; NbExp=3; IntAct=EBI-11742507, EBI-25885139;
CC Q8TAP4-4; Q96D09: GPRASP2; NbExp=3; IntAct=EBI-11742507, EBI-473189;
CC Q8TAP4-4; Q13322-4: GRB10; NbExp=3; IntAct=EBI-11742507, EBI-12353035;
CC Q8TAP4-4; P62805: H4C9; NbExp=3; IntAct=EBI-11742507, EBI-302023;
CC Q8TAP4-4; O00165: HAX1; NbExp=3; IntAct=EBI-11742507, EBI-357001;
CC Q8TAP4-4; Q8N7T0: hCG_1820408; NbExp=3; IntAct=EBI-11742507, EBI-25858908;
CC Q8TAP4-4; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-11742507, EBI-2549423;
CC Q8TAP4-4; P52597: HNRNPF; NbExp=3; IntAct=EBI-11742507, EBI-352986;
CC Q8TAP4-4; P31943: HNRNPH1; NbExp=3; IntAct=EBI-11742507, EBI-351590;
CC Q8TAP4-4; Q92826: HOXB13; NbExp=3; IntAct=EBI-11742507, EBI-11317274;
CC Q8TAP4-4; P09017: HOXC4; NbExp=3; IntAct=EBI-11742507, EBI-3923226;
CC Q8TAP4-4; Q03933-2: HSF2; NbExp=3; IntAct=EBI-11742507, EBI-10223348;
CC Q8TAP4-4; Q16082: HSPB2; NbExp=3; IntAct=EBI-11742507, EBI-739395;
CC Q8TAP4-4; Q02363: ID2; NbExp=3; IntAct=EBI-11742507, EBI-713450;
CC Q8TAP4-4; Q96FT9-2: IFT43; NbExp=3; IntAct=EBI-11742507, EBI-11944538;
CC Q8TAP4-4; P78318: IGBP1; NbExp=3; IntAct=EBI-11742507, EBI-1055954;
CC Q8TAP4-4; P17936: IGFBP3; NbExp=3; IntAct=EBI-11742507, EBI-715709;
CC Q8TAP4-4; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-11742507, EBI-11522367;
CC Q8TAP4-4; Q14005-2: IL16; NbExp=3; IntAct=EBI-11742507, EBI-17178971;
CC Q8TAP4-4; P26951: IL3RA; NbExp=3; IntAct=EBI-11742507, EBI-1757512;
CC Q8TAP4-4; Q0VD86: INCA1; NbExp=5; IntAct=EBI-11742507, EBI-6509505;
CC Q8TAP4-4; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11742507, EBI-2556193;
CC Q8TAP4-4; Q719H9: KCTD1; NbExp=3; IntAct=EBI-11742507, EBI-9027502;
CC Q8TAP4-4; Q8N5Z5: KCTD17; NbExp=3; IntAct=EBI-11742507, EBI-743960;
CC Q8TAP4-4; O00139-1: KIF2A; NbExp=3; IntAct=EBI-11742507, EBI-12197879;
CC Q8TAP4-4; Q9Y4X4: KLF12; NbExp=3; IntAct=EBI-11742507, EBI-750750;
CC Q8TAP4-4; Q5JUW0-3: KRBOX4; NbExp=6; IntAct=EBI-11742507, EBI-12893625;
CC Q8TAP4-4; Q15323: KRT31; NbExp=3; IntAct=EBI-11742507, EBI-948001;
CC Q8TAP4-4; O76015: KRT38; NbExp=3; IntAct=EBI-11742507, EBI-1047263;
CC Q8TAP4-4; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-11742507, EBI-9996449;
CC Q8TAP4-4; Q86U70-2: LDB1; NbExp=6; IntAct=EBI-11742507, EBI-11979761;
CC Q8TAP4-4; O43679: LDB2; NbExp=5; IntAct=EBI-11742507, EBI-2865580;
CC Q8TAP4-4; Q9H2C1: LHX5; NbExp=3; IntAct=EBI-11742507, EBI-25835523;
CC Q8TAP4-4; P48059-3: LIMS1; NbExp=3; IntAct=EBI-11742507, EBI-12864460;
CC Q8TAP4-4; Q9Y234: LIPT1; NbExp=3; IntAct=EBI-11742507, EBI-727376;
CC Q8TAP4-4; Q9C0E8-2: LNPK; NbExp=3; IntAct=EBI-11742507, EBI-11024283;
CC Q8TAP4-4; O60711: LPXN; NbExp=3; IntAct=EBI-11742507, EBI-744222;
CC Q8TAP4-4; P51884: LUM; NbExp=3; IntAct=EBI-11742507, EBI-725780;
CC Q8TAP4-4; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-11742507, EBI-1216080;
CC Q8TAP4-4; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-11742507, EBI-741037;
CC Q8TAP4-4; Q96GV9: MACIR; NbExp=3; IntAct=EBI-11742507, EBI-2350695;
CC Q8TAP4-4; Q9Y6D9: MAD1L1; NbExp=3; IntAct=EBI-11742507, EBI-742610;
CC Q8TAP4-4; Q9H213: MAGEH1; NbExp=3; IntAct=EBI-11742507, EBI-473834;
CC Q8TAP4-4; Q96EH3: MALSU1; NbExp=3; IntAct=EBI-11742507, EBI-2339737;
CC Q8TAP4-4; P80192: MAP3K9; NbExp=3; IntAct=EBI-11742507, EBI-3951604;
CC Q8TAP4-4; Q15759: MAPK11; NbExp=3; IntAct=EBI-11742507, EBI-298304;
CC Q8TAP4-4; O95983-2: MBD3; NbExp=3; IntAct=EBI-11742507, EBI-11978579;
CC Q8TAP4-4; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-11742507, EBI-12516603;
CC Q8TAP4-4; A0JLT2-2: MED19; NbExp=3; IntAct=EBI-11742507, EBI-13288755;
CC Q8TAP4-4; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-11742507, EBI-18582591;
CC Q8TAP4-4; Q9H8H3: METTL7A; NbExp=3; IntAct=EBI-11742507, EBI-1390168;
CC Q8TAP4-4; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-11742507, EBI-10172526;
CC Q8TAP4-4; P41218: MNDA; NbExp=3; IntAct=EBI-11742507, EBI-2829677;
CC Q8TAP4-4; Q8N983-3: MRPL43; NbExp=3; IntAct=EBI-11742507, EBI-11109389;
CC Q8TAP4-4; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11742507, EBI-11522433;
CC Q8TAP4-4; P15173: MYOG; NbExp=3; IntAct=EBI-11742507, EBI-3906629;
CC Q8TAP4-4; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-11742507, EBI-5662487;
CC Q8TAP4-4; Q9UHB4: NDOR1; NbExp=3; IntAct=EBI-11742507, EBI-10249760;
CC Q8TAP4-4; Q16718: NDUFA5; NbExp=3; IntAct=EBI-11742507, EBI-746417;
CC Q8TAP4-4; P49821: NDUFV1; NbExp=3; IntAct=EBI-11742507, EBI-748312;
CC Q8TAP4-4; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-11742507, EBI-10271199;
CC Q8TAP4-4; Q9GZT8: NIF3L1; NbExp=3; IntAct=EBI-11742507, EBI-740897;
CC Q8TAP4-4; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-11742507, EBI-741158;
CC Q8TAP4-4; Q2M1J6: OXA1L; NbExp=3; IntAct=EBI-11742507, EBI-9978021;
CC Q8TAP4-4; Q16342: PDCD2; NbExp=3; IntAct=EBI-11742507, EBI-359462;
CC Q8TAP4-4; Q9BRX2: PELO; NbExp=9; IntAct=EBI-11742507, EBI-1043580;
CC Q8TAP4-4; Q9Y6X2: PIAS3; NbExp=3; IntAct=EBI-11742507, EBI-2803703;
CC Q8TAP4-4; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-11742507, EBI-79165;
CC Q8TAP4-4; Q86T03: PIP4P1; NbExp=3; IntAct=EBI-11742507, EBI-6164623;
CC Q8TAP4-4; Q6P1J6-2: PLB1; NbExp=3; IntAct=EBI-11742507, EBI-10694821;
CC Q8TAP4-4; Q8ND90: PNMA1; NbExp=5; IntAct=EBI-11742507, EBI-302345;
CC Q8TAP4-4; Q9UNA4: POLI; NbExp=3; IntAct=EBI-11742507, EBI-741774;
CC Q8TAP4-4; P78424: POU6F2; NbExp=3; IntAct=EBI-11742507, EBI-12029004;
CC Q8TAP4-4; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-11742507, EBI-1105153;
CC Q8TAP4-4; P07225: PROS1; NbExp=3; IntAct=EBI-11742507, EBI-2803380;
CC Q8TAP4-4; P49023-2: PXN; NbExp=3; IntAct=EBI-11742507, EBI-11954250;
CC Q8TAP4-4; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-11742507, EBI-2798044;
CC Q8TAP4-4; Q3YEC7-3: RABL6; NbExp=3; IntAct=EBI-11742507, EBI-25885259;
CC Q8TAP4-4; Q96I51: RCC1L; NbExp=3; IntAct=EBI-11742507, EBI-2117080;
CC Q8TAP4-4; Q15293: RCN1; NbExp=3; IntAct=EBI-11742507, EBI-948278;
CC Q8TAP4-4; P40937: RFC5; NbExp=3; IntAct=EBI-11742507, EBI-712376;
CC Q8TAP4-4; O94844: RHOBTB1; NbExp=3; IntAct=EBI-11742507, EBI-6426999;
CC Q8TAP4-4; Q9UJD0: RIMS3; NbExp=3; IntAct=EBI-11742507, EBI-3909436;
CC Q8TAP4-4; Q9NWS8-3: RMND1; NbExp=3; IntAct=EBI-11742507, EBI-25884400;
CC Q8TAP4-4; Q9Y508: RNF114; NbExp=3; IntAct=EBI-11742507, EBI-723587;
CC Q8TAP4-4; Q9ULK6-3: RNF150; NbExp=3; IntAct=EBI-11742507, EBI-23640835;
CC Q8TAP4-4; P62913-2: RPL11; NbExp=3; IntAct=EBI-11742507, EBI-11027771;
CC Q8TAP4-4; P18077: RPL35A; NbExp=3; IntAct=EBI-11742507, EBI-353383;
CC Q8TAP4-4; Q99643: SDHC; NbExp=3; IntAct=EBI-11742507, EBI-1224539;
CC Q8TAP4-4; Q14141: SEPTIN6; NbExp=3; IntAct=EBI-11742507, EBI-745901;
CC Q8TAP4-4; Q01105-2: SET; NbExp=3; IntAct=EBI-11742507, EBI-7481343;
CC Q8TAP4-4; O14492-2: SH2B2; NbExp=3; IntAct=EBI-11742507, EBI-19952306;
CC Q8TAP4-4; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-11742507, EBI-12037847;
CC Q8TAP4-4; Q8ND83: SLAIN1; NbExp=3; IntAct=EBI-11742507, EBI-10269374;
CC Q8TAP4-4; Q13573: SNW1; NbExp=3; IntAct=EBI-11742507, EBI-632715;
CC Q8TAP4-4; Q9Y5X0: SNX10; NbExp=3; IntAct=EBI-11742507, EBI-10329478;
CC Q8TAP4-4; Q8WV41: SNX33; NbExp=3; IntAct=EBI-11742507, EBI-2481535;
CC Q8TAP4-4; P56693: SOX10; NbExp=3; IntAct=EBI-11742507, EBI-1167533;
CC Q8TAP4-4; Q9BRW5: SP2; NbExp=3; IntAct=EBI-11742507, EBI-25868254;
CC Q8TAP4-4; Q13586: STIM1; NbExp=3; IntAct=EBI-11742507, EBI-448878;
CC Q8TAP4-4; Q13033-2: STRN3; NbExp=3; IntAct=EBI-11742507, EBI-1053876;
CC Q8TAP4-4; O43761: SYNGR3; NbExp=3; IntAct=EBI-11742507, EBI-11321949;
CC Q8TAP4-4; P15884: TCF4; NbExp=3; IntAct=EBI-11742507, EBI-533224;
CC Q8TAP4-4; Q8TDR4: TCP10L; NbExp=3; IntAct=EBI-11742507, EBI-3923210;
CC Q8TAP4-4; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-11742507, EBI-11139477;
CC Q8TAP4-4; Q92481: TFAP2B; NbExp=3; IntAct=EBI-11742507, EBI-725275;
CC Q8TAP4-4; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-11742507, EBI-741515;
CC Q8TAP4-4; Q9BTD3: TMEM121; NbExp=3; IntAct=EBI-11742507, EBI-12155101;
CC Q8TAP4-4; Q3YBM2: TMEM176B; NbExp=3; IntAct=EBI-11742507, EBI-2821479;
CC Q8TAP4-4; Q969K7: TMEM54; NbExp=3; IntAct=EBI-11742507, EBI-3922833;
CC Q8TAP4-4; P51580: TPMT; NbExp=3; IntAct=EBI-11742507, EBI-25902017;
CC Q8TAP4-4; Q9UL33-2: TRAPPC2L; NbExp=3; IntAct=EBI-11742507, EBI-11119202;
CC Q8TAP4-4; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-11742507, EBI-492476;
CC Q8TAP4-4; P36406: TRIM23; NbExp=3; IntAct=EBI-11742507, EBI-740098;
CC Q8TAP4-4; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-11742507, EBI-2130429;
CC Q8TAP4-4; Q9UJA5: TRMT6; NbExp=3; IntAct=EBI-11742507, EBI-934061;
CC Q8TAP4-4; Q99598: TSNAX; NbExp=3; IntAct=EBI-11742507, EBI-742638;
CC Q8TAP4-4; Q9NNX1: TUFT1; NbExp=3; IntAct=EBI-11742507, EBI-2557363;
CC Q8TAP4-4; Q8NB14: USP38; NbExp=3; IntAct=EBI-11742507, EBI-2512509;
CC Q8TAP4-4; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-11742507, EBI-11975223;
CC Q8TAP4-4; Q15836: VAMP3; NbExp=3; IntAct=EBI-11742507, EBI-722343;
CC Q8TAP4-4; P61758: VBP1; NbExp=3; IntAct=EBI-11742507, EBI-357430;
CC Q8TAP4-4; Q2NL98: VMAC; NbExp=3; IntAct=EBI-11742507, EBI-2803134;
CC Q8TAP4-4; O95498: VNN2; NbExp=3; IntAct=EBI-11742507, EBI-21494555;
CC Q8TAP4-4; Q9UK41-2: VPS28; NbExp=3; IntAct=EBI-11742507, EBI-12146727;
CC Q8TAP4-4; Q9NZC7-5: WWOX; NbExp=6; IntAct=EBI-11742507, EBI-12040603;
CC Q8TAP4-4; O43298: ZBTB43; NbExp=3; IntAct=EBI-11742507, EBI-740718;
CC Q8TAP4-4; Q8NAP8: ZBTB8B; NbExp=3; IntAct=EBI-11742507, EBI-17494306;
CC Q8TAP4-4; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-11742507, EBI-14104088;
CC Q8TAP4-4; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-11742507, EBI-2849569;
CC Q8TAP4-4; Q96PE6: ZIM3; NbExp=3; IntAct=EBI-11742507, EBI-18199075;
CC Q8TAP4-4; Q15776: ZKSCAN8; NbExp=3; IntAct=EBI-11742507, EBI-2602314;
CC Q8TAP4-4; Q14202: ZMYM3; NbExp=3; IntAct=EBI-11742507, EBI-2556139;
CC Q8TAP4-4; P52747: ZNF143; NbExp=3; IntAct=EBI-11742507, EBI-2849334;
CC Q8TAP4-4; Q05CR2: ZNF248; NbExp=3; IntAct=EBI-11742507, EBI-25835471;
CC Q8TAP4-4; Q9UL40: ZNF346; NbExp=3; IntAct=EBI-11742507, EBI-2462313;
CC Q8TAP4-4; Q8N0Y2-2: ZNF444; NbExp=3; IntAct=EBI-11742507, EBI-12010736;
CC Q8TAP4-4; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-11742507, EBI-11035148;
CC Q8TAP4-4; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11742507, EBI-6427977;
CC Q8TAP4-4; Q6ZNG0: ZNF620; NbExp=3; IntAct=EBI-11742507, EBI-4395669;
CC Q8TAP4-4; Q96N77-2: ZNF641; NbExp=3; IntAct=EBI-11742507, EBI-12939666;
CC Q8TAP4-4; Q9UC07-2: ZNF69; NbExp=3; IntAct=EBI-11742507, EBI-12310821;
CC Q8TAP4-4; P51523: ZNF84; NbExp=3; IntAct=EBI-11742507, EBI-2849074;
CC Q8TAP4-4; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-11742507, EBI-527853;
CC Q8TAP4-4; O15535: ZSCAN9; NbExp=6; IntAct=EBI-11742507, EBI-751531;
CC Q8TAP4-4; Q9HBH6; NbExp=3; IntAct=EBI-11742507, EBI-25901704;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8TAP4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAP4-2; Sequence=VSP_045313;
CC Name=3;
CC IsoId=Q8TAP4-3; Sequence=VSP_045312;
CC Name=4;
CC IsoId=Q8TAP4-4; Sequence=VSP_047379;
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DR EMBL; AB044745; BAD93349.1; -; mRNA.
DR EMBL; AB044746; BAD93350.1; -; mRNA.
DR EMBL; AK095595; BAC04582.1; -; mRNA.
DR EMBL; AK294474; BAG57701.1; -; mRNA.
DR EMBL; AK294909; BAG57996.1; -; mRNA.
DR EMBL; AK316021; BAH14392.1; -; mRNA.
DR EMBL; AC007529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC007552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471094; EAW96371.1; -; Genomic_DNA.
DR EMBL; BC026311; AAH26311.1; -; mRNA.
DR EMBL; BC050085; AAH50085.1; -; mRNA.
DR CCDS; CCDS58210.1; -. [Q8TAP4-2]
DR CCDS; CCDS58211.1; -. [Q8TAP4-3]
DR CCDS; CCDS58212.1; -. [Q8TAP4-4]
DR CCDS; CCDS8678.1; -. [Q8TAP4-1]
DR RefSeq; NP_001001395.1; NM_001001395.2. [Q8TAP4-1]
DR RefSeq; NP_001230538.1; NM_001243609.1. [Q8TAP4-1]
DR RefSeq; NP_001230539.1; NM_001243610.1. [Q8TAP4-1]
DR RefSeq; NP_001230540.1; NM_001243611.1. [Q8TAP4-3]
DR RefSeq; NP_001230541.1; NM_001243612.1. [Q8TAP4-4]
DR RefSeq; NP_001230542.1; NM_001243613.1. [Q8TAP4-2]
DR RefSeq; NP_061110.2; NM_018640.4. [Q8TAP4-1]
DR RefSeq; XP_006719173.1; XM_006719110.3. [Q8TAP4-1]
DR RefSeq; XP_006719174.1; XM_006719111.2. [Q8TAP4-1]
DR RefSeq; XP_011519064.1; XM_011520762.1. [Q8TAP4-1]
DR RefSeq; XP_011519065.1; XM_011520763.1. [Q8TAP4-1]
DR AlphaFoldDB; Q8TAP4; -.
DR SMR; Q8TAP4; -.
DR BioGRID; 120977; 145.
DR DIP; DIP-50129N; -.
DR IntAct; Q8TAP4; 225.
DR MINT; Q8TAP4; -.
DR iPTMnet; Q8TAP4; -.
DR PhosphoSitePlus; Q8TAP4; -.
DR BioMuta; LMO3; -.
DR DMDM; 34098603; -.
DR MassIVE; Q8TAP4; -.
DR MaxQB; Q8TAP4; -.
DR PaxDb; Q8TAP4; -.
DR PeptideAtlas; Q8TAP4; -.
DR PRIDE; Q8TAP4; -.
DR ProteomicsDB; 4115; -.
DR ProteomicsDB; 4187; -.
DR ProteomicsDB; 73900; -. [Q8TAP4-1]
DR Antibodypedia; 23835; 284 antibodies from 28 providers.
DR DNASU; 55885; -.
DR Ensembl; ENST00000261169.10; ENSP00000261169.6; ENSG00000048540.16. [Q8TAP4-3]
DR Ensembl; ENST00000320122.10; ENSP00000312856.6; ENSG00000048540.16. [Q8TAP4-1]
DR Ensembl; ENST00000354662.5; ENSP00000346689.1; ENSG00000048540.16. [Q8TAP4-1]
DR Ensembl; ENST00000441439.6; ENSP00000412479.2; ENSG00000048540.16. [Q8TAP4-1]
DR Ensembl; ENST00000447609.5; ENSP00000413703.1; ENSG00000048540.16. [Q8TAP4-1]
DR Ensembl; ENST00000534946.5; ENSP00000439275.1; ENSG00000048540.16. [Q8TAP4-1]
DR Ensembl; ENST00000535535.5; ENSP00000446115.1; ENSG00000048540.16. [Q8TAP4-1]
DR Ensembl; ENST00000537304.6; ENSP00000440099.1; ENSG00000048540.16. [Q8TAP4-1]
DR Ensembl; ENST00000540445.5; ENSP00000442786.1; ENSG00000048540.16. [Q8TAP4-2]
DR Ensembl; ENST00000540848.5; ENSP00000445751.1; ENSG00000048540.16. [Q8TAP4-1]
DR Ensembl; ENST00000541295.5; ENSP00000446463.1; ENSG00000048540.16. [Q8TAP4-4]
DR Ensembl; ENST00000541846.5; ENSP00000444393.1; ENSG00000048540.16. [Q8TAP4-1]
DR GeneID; 55885; -.
DR KEGG; hsa:55885; -.
DR MANE-Select; ENST00000537304.6; ENSP00000440099.1; NM_018640.5; NP_061110.2.
DR UCSC; uc001rdj.3; human. [Q8TAP4-1]
DR CTD; 55885; -.
DR DisGeNET; 55885; -.
DR GeneCards; LMO3; -.
DR HGNC; HGNC:6643; LMO3.
DR HPA; ENSG00000048540; Tissue enhanced (brain).
DR MIM; 180386; gene.
DR neXtProt; NX_Q8TAP4; -.
DR OpenTargets; ENSG00000048540; -.
DR PharmGKB; PA30409; -.
DR VEuPathDB; HostDB:ENSG00000048540; -.
DR GeneTree; ENSGT00940000153908; -.
DR HOGENOM; CLU_001357_7_1_1; -.
DR InParanoid; Q8TAP4; -.
DR OMA; XLFGVTG; -.
DR OrthoDB; 1307952at2759; -.
DR PhylomeDB; Q8TAP4; -.
DR TreeFam; TF351071; -.
DR PathwayCommons; Q8TAP4; -.
DR SignaLink; Q8TAP4; -.
DR SIGNOR; Q8TAP4; -.
DR BioGRID-ORCS; 55885; 8 hits in 1067 CRISPR screens.
DR ChiTaRS; LMO3; human.
DR GeneWiki; LMO3; -.
DR GenomeRNAi; 55885; -.
DR Pharos; Q8TAP4; Tbio.
DR PRO; PR:Q8TAP4; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8TAP4; protein.
DR Bgee; ENSG00000048540; Expressed in middle temporal gyrus and 163 other tissues.
DR ExpressionAtlas; Q8TAP4; baseline and differential.
DR Genevisible; Q8TAP4; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IMP:UniProtKB.
DR GO; GO:2000324; P:positive regulation of glucocorticoid receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0035360; P:positive regulation of peroxisome proliferator activated receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; LIM domain; Metal-binding; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..145
FT /note="LIM domain only protein 3"
FT /id="PRO_0000075817"
FT DOMAIN 11..73
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 75..137
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT VAR_SEQ 1
FT /note="M -> MQKKEKSFGIQM (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_045312"
FT VAR_SEQ 1
FT /note="M -> MLMEGGRAAAARNVSSIQM (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047379"
FT VAR_SEQ 50..69
FT /note="VGSTLYTKANLILCRRDYLR -> HLKRCGSIYIHAAHTEIGICVTLEWPLP
FT FVIIDFSQQITIAW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045313"
FT CONFLICT 29
FT /note="L -> P (in Ref. 2; BAC04582)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 145 AA; 16594 MW; 05284546BA5EC226 CRC64;
MLSVQPDTKP KGCAGCNRKI KDRYLLKALD KYWHEDCLKC ACCDCRLGEV GSTLYTKANL
ILCRRDYLRL FGVTGNCAAC SKLIPAFEMV MRAKDNVYHL DCFACQLCNQ RFCVGDKFFL
KNNMILCQTD YEEGLMKEGY APQVR
