LMO3_MOUSE
ID LMO3_MOUSE Reviewed; 145 AA.
AC Q8BZL8;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=LIM domain only protein 3;
DE Short=LMO-3;
DE AltName: Full=Neuronal-specific transcription factor DAT1;
GN Name=Lmo3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK034177; BAC28617.1; -; mRNA.
DR EMBL; BC057086; AAH57086.1; -; mRNA.
DR CCDS; CCDS20669.1; -.
DR RefSeq; NP_997105.1; NM_207222.2.
DR RefSeq; XP_006505403.1; XM_006505340.1.
DR RefSeq; XP_006505404.1; XM_006505341.3.
DR RefSeq; XP_006505405.1; XM_006505342.2.
DR RefSeq; XP_006505407.1; XM_006505344.3.
DR RefSeq; XP_011239433.1; XM_011241131.2.
DR RefSeq; XP_011239434.1; XM_011241132.2.
DR RefSeq; XP_011239435.1; XM_011241133.2.
DR RefSeq; XP_017176802.1; XM_017321313.1.
DR AlphaFoldDB; Q8BZL8; -.
DR SMR; Q8BZL8; -.
DR BioGRID; 224886; 6.
DR IntAct; Q8BZL8; 6.
DR STRING; 10090.ENSMUSP00000125335; -.
DR PhosphoSitePlus; Q8BZL8; -.
DR MaxQB; Q8BZL8; -.
DR PaxDb; Q8BZL8; -.
DR PRIDE; Q8BZL8; -.
DR ProteomicsDB; 290134; -.
DR Antibodypedia; 23835; 284 antibodies from 28 providers.
DR DNASU; 109593; -.
DR Ensembl; ENSMUST00000161450; ENSMUSP00000124862; ENSMUSG00000030226.
DR Ensembl; ENSMUST00000162772; ENSMUSP00000125335; ENSMUSG00000030226.
DR Ensembl; ENSMUST00000163024; ENSMUSP00000125589; ENSMUSG00000030226.
DR Ensembl; ENSMUST00000203435; ENSMUSP00000145048; ENSMUSG00000030226.
DR GeneID; 109593; -.
DR KEGG; mmu:109593; -.
DR UCSC; uc009enl.1; mouse.
DR CTD; 55885; -.
DR MGI; MGI:102810; Lmo3.
DR VEuPathDB; HostDB:ENSMUSG00000030226; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000153908; -.
DR HOGENOM; CLU_001357_7_1_1; -.
DR InParanoid; Q8BZL8; -.
DR PhylomeDB; Q8BZL8; -.
DR TreeFam; TF351071; -.
DR BioGRID-ORCS; 109593; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8BZL8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BZL8; protein.
DR Bgee; ENSMUSG00000030226; Expressed in piriform cortex and 100 other tissues.
DR ExpressionAtlas; Q8BZL8; baseline and differential.
DR Genevisible; Q8BZL8; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:2000324; P:positive regulation of glucocorticoid receptor signaling pathway; ISO:MGI.
DR GO; GO:0035360; P:positive regulation of peroxisome proliferator activated receptor signaling pathway; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW LIM domain; Metal-binding; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..145
FT /note="LIM domain only protein 3"
FT /id="PRO_0000075818"
FT DOMAIN 11..73
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 75..137
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ SEQUENCE 145 AA; 16594 MW; 05284546BA5EC226 CRC64;
MLSVQPDTKP KGCAGCNRKI KDRYLLKALD KYWHEDCLKC ACCDCRLGEV GSTLYTKANL
ILCRRDYLRL FGVTGNCAAC SKLIPAFEMV MRAKDNVYHL DCFACQLCNQ RFCVGDKFFL
KNNMILCQTD YEEGLMKEGY APQVR
