ID   LMO3_RAT                Reviewed;         145 AA.
AC   Q99MB5;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=LIM domain only protein 3;
DE            Short=LMO-3;
DE   AltName: Full=Neuronal-specific transcription factor DAT1;
GN   Name=Lmo3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Shi J., Cai W., Xie Y.Y., Ying K., Wu C., Zhou Z.;
RT   "Molecular cloning and characterization of a new dopamine-inducible LIM-
RT   domain transcription factor from cultured astrocytes.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- INDUCTION: By dopamine.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK31207.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF353304; AAK31207.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q99MB5; -.
DR   SMR; Q99MB5; -.
DR   STRING; 10116.ENSRNOP00000064297; -.
DR   PaxDb; Q99MB5; -.
DR   UCSC; RGD:621166; rat.
DR   RGD; 621166; Lmo3.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; Q99MB5; -.
DR   PhylomeDB; Q99MB5; -.
DR   Reactome; R-RNO-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR   PRO; PR:Q99MB5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0046013; P:regulation of T cell homeostatic proliferation; ISO:RGD.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   LIM domain; Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..145
FT                   /note="LIM domain only protein 3"
FT                   /id="PRO_0000075819"
FT   DOMAIN          11..73
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          75..137
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ   SEQUENCE   145 AA;  16624 MW;  589218F8EC904FC1 CRC64;
     MLSVQPKGKQ KGCAGCNRKI KDRYLLKALD KYWHEDCLKC ACCDCRLGEV GSTLYTKANL
     ILCRRDYLRL FGTTGNCAAC SKLIPAFEMV MRARDNVYHL DCFACQLCNQ RFCVGDKFFL
     KNNMILCQTD YEEGLMKEGY APQVR