ID   LMO41_XENTR             Reviewed;         167 AA.
AC   Q5FVB2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=LIM domain transcription factor LMO4.1;
DE   AltName: Full=LIM domain only protein 4.1;
DE            Short=LMO-4.1;
GN   Name=lmo4.1; Synonyms=lmo4 {ECO:0000312|EMBL:AAH90104.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH90104.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:AAH90104.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a positive cofactor of GATA transcription factors to
CC       establish the identity of the ventral mesoderm during gastrulation.
CC       Down-regulation in the dorsal mesoderm is necessary for the proper
CC       formation of this territory since, when present, lmo4 may bind ldb1 and
CC       restrict the availability of this cofactor for Spemman organizer
CC       transcription factors. At neurula stages, suppresses primary neuron
CC       differentiation and modulates gene expression at the Isthmic Organizer
CC       of the midbrain-hindbrain boundary (By similarity).
CC       {ECO:0000250|UniProtKB:Q8AW92}.
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DR   EMBL; BC090104; AAH90104.1; -; mRNA.
DR   RefSeq; NP_001015822.1; NM_001015822.1.
DR   AlphaFoldDB; Q5FVB2; -.
DR   SMR; Q5FVB2; -.
DR   STRING; 8364.ENSXETP00000050669; -.
DR   PaxDb; Q5FVB2; -.
DR   DNASU; 548539; -.
DR   GeneID; 548539; -.
DR   KEGG; xtr:548539; -.
DR   CTD; 548539; -.
DR   Xenbase; XB-GENE-479327; lmo4.2.
DR   eggNOG; KOG0490; Eukaryota.
DR   HOGENOM; CLU_001357_7_1_1; -.
DR   InParanoid; Q5FVB2; -.
DR   OMA; PMLPDQK; -.
DR   OrthoDB; 1307952at2759; -.
DR   PhylomeDB; Q5FVB2; -.
DR   TreeFam; TF351071; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0007498; P:mesoderm development; ISS:UniProtKB.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Gastrulation; LIM domain;
KW   Metal-binding; Neurogenesis; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..167
FT                   /note="LIM domain transcription factor LMO4.1"
FT                   /id="PRO_0000317223"
FT   DOMAIN          22..84
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          86..148
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   167 AA;  18158 MW;  2EA95DCB349F2ED4 CRC64;
     MVNNRVTEST TTAVSSNGGP PKACAGCGGK IADRFLLYSM ERYWHTRCLK CSCCQAQLGE
     IGTSCYTKSG MILCRNDYIR LFGSSGACSA CGQSIPASEM VMRAQGSVYH LKCFTCATCR
     NRLVPGDRFH YVNGAIFCEH DRPTGLLSGH LNPLQSNPPM LPDQKVC