ID   LMO42_XENTR             Reviewed;         165 AA.
AC   Q6DJ06;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=LIM domain transcription factor LMO4.2;
DE   AltName: Full=LIM domain only protein 4.2;
DE            Short=LMO-4.2;
GN   Name=lmo4.2; Synonyms=lmo4 {ECO:0000312|EMBL:CAJ82708.1};
GN   ORFNames=TNeu050b22.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ82708.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:CAJ82708.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ82708.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=F6 {ECO:0000312|EMBL:AAH75379.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a positive cofactor of GATA transcription factors to
CC       establish the identity of the ventral mesoderm during gastrulation.
CC       Down-regulation in the dorsal mesoderm is necessary for the proper
CC       formation of this territory since, when present, lmo4 may bind ldb1 and
CC       restrict the availability of this cofactor for Spemman organizer
CC       transcription factors. At neurula stages, suppresses primary neuron
CC       differentiation and modulates gene expression at the Isthmic Organizer
CC       of the midbrain-hindbrain boundary (By similarity).
CC       {ECO:0000250|UniProtKB:Q8AW92}.
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DR   EMBL; CR760333; CAJ82708.1; -; mRNA.
DR   EMBL; BC075379; AAH75379.1; -; mRNA.
DR   RefSeq; NP_001004922.1; NM_001004922.1.
DR   AlphaFoldDB; Q6DJ06; -.
DR   BMRB; Q6DJ06; -.
DR   SMR; Q6DJ06; -.
DR   STRING; 8364.ENSXETP00000053847; -.
DR   PaxDb; Q6DJ06; -.
DR   DNASU; 448304; -.
DR   Ensembl; ENSXETT00000053847; ENSXETP00000053847; ENSXETG00000023295.
DR   GeneID; 448304; -.
DR   KEGG; xtr:448304; -.
DR   CTD; 448304; -.
DR   Xenbase; XB-GENE-971939; lmo4.1.
DR   eggNOG; KOG0490; Eukaryota.
DR   HOGENOM; CLU_001357_7_1_1; -.
DR   InParanoid; Q6DJ06; -.
DR   OMA; NNVVRCC; -.
DR   OrthoDB; 1307952at2759; -.
DR   TreeFam; TF351071; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023295; Expressed in brain and 14 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0007498; P:mesoderm development; ISS:UniProtKB.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Gastrulation; LIM domain;
KW   Metal-binding; Neurogenesis; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..165
FT                   /note="LIM domain transcription factor LMO4.2"
FT                   /id="PRO_0000317224"
FT   DOMAIN          21..83
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          85..147
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ   SEQUENCE   165 AA;  18052 MW;  69E45F6464D78B1D CRC64;
     MVNPGSSSQP PPVTASTLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC SCCQAQLGEI
     GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV MRAQGNVYHL KCFTCSTCRN
     RLVPGDRFHY INGSLFCEHD RPTALINGHL NSLQSNPLLP DQKVC