ID   LMO4B_XENLA             Reviewed;         171 AA.
AC   Q801P0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=LIM domain transcription factor LMO4-B;
DE   AltName: Full=LIM domain only protein 4-B;
DE            Short=LMO-4-B;
GN   Name=lmo4-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH48020.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud {ECO:0000312|EMBL:AAH48020.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a positive cofactor of GATA transcription factors to
CC       establish the identity of the ventral mesoderm during gastrulation.
CC       Down-regulation in the dorsal mesoderm is necessary for the proper
CC       formation of this territory since, when present, lmo4 may bind ldb1 and
CC       restrict the availability of this cofactor for Spemman organizer
CC       transcription factors. At neurula stages, suppresses primary neuron
CC       differentiation and modulates gene expression at the Isthmic Organizer
CC       of the midbrain-hindbrain boundary (By similarity).
CC       {ECO:0000250|UniProtKB:Q8AW92}.
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DR   EMBL; BC048020; AAH48020.1; -; mRNA.
DR   RefSeq; NP_001079705.1; NM_001086236.1.
DR   AlphaFoldDB; Q801P0; -.
DR   SMR; Q801P0; -.
DR   GeneID; 379392; -.
DR   KEGG; xla:379392; -.
DR   CTD; 379392; -.
DR   Xenbase; XB-GENE-6256064; lmo4.2.S.
DR   OMA; PMLPDQK; -.
DR   OrthoDB; 1307952at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 379392; Expressed in heart and 19 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0007498; P:mesoderm development; ISS:UniProtKB.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Gastrulation; LIM domain;
KW   Metal-binding; Neurogenesis; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..171
FT                   /note="LIM domain transcription factor LMO4-B"
FT                   /id="PRO_0000317222"
FT   DOMAIN          22..84
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          86..148
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   171 AA;  18697 MW;  E1EE9488ADC5407D CRC64;
     MVNNRISEST TTAVSNNGSP PKACAGCGGK IADRFLLYSM DRYWHTRCLK CSCCQAQLGE
     IGTSCYTKSG MILCRNDYIR LFGNSGACNA CGQSIPASEM VMRAQGSVYH LKCFTCATCR
     NRLVPGDRFH YVNGTIFCEH DRPTGLLNGH LNPLQSNPLQ GSPMLPDQKV C