ID   LMO4_BOVIN              Reviewed;         165 AA.
AC   Q3SWZ8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=LIM domain transcription factor LMO4;
DE   AltName: Full=LIM domain only protein 4;
DE            Short=LMO-4;
GN   Name=LMO4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcriptional factor. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts strongly with LDBS. Interacts with DEAF1; LMO4
CC       blocks export from nucleus. Interacts with CLIM1 and CLIM2. Interacts
CC       (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1
CC       (via the BRCT domains); the interaction represses BRCA1 transcriptional
CC       activity (By similarity). {ECO:0000250}.
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DR   EMBL; BC104582; AAI04583.1; -; mRNA.
DR   RefSeq; NP_001029923.1; NM_001034751.1.
DR   AlphaFoldDB; Q3SWZ8; -.
DR   BMRB; Q3SWZ8; -.
DR   SMR; Q3SWZ8; -.
DR   STRING; 9913.ENSBTAP00000000389; -.
DR   PaxDb; Q3SWZ8; -.
DR   PRIDE; Q3SWZ8; -.
DR   Ensembl; ENSBTAT00000000389; ENSBTAP00000000389; ENSBTAG00000000305.
DR   GeneID; 614212; -.
DR   KEGG; bta:614212; -.
DR   CTD; 8543; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000305; -.
DR   VGNC; VGNC:30936; LMO4.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000157730; -.
DR   HOGENOM; CLU_001357_7_1_1; -.
DR   InParanoid; Q3SWZ8; -.
DR   OMA; NNVVRCC; -.
DR   OrthoDB; 1307952at2759; -.
DR   TreeFam; TF351071; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000000305; Expressed in occipital lobe and 103 other tissues.
DR   ExpressionAtlas; Q3SWZ8; baseline and differential.
DR   GO; GO:0031252; C:cell leading edge; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0001843; P:neural tube closure; ISS:UniProtKB.
DR   GO; GO:0033674; P:positive regulation of kinase activity; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   LIM domain; Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..165
FT                   /note="LIM domain transcription factor LMO4"
FT                   /id="PRO_0000265108"
FT   DOMAIN          23..83
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          87..147
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ   SEQUENCE   165 AA;  17994 MW;  C8AC295144AD7787 CRC64;
     MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC SCCQAQLGDI
     GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV MRAQGNVYHL KCFTCSTCRN
     RLVPGDRFHY INGSLFCEHD RPTALINGHL NSLQSNPLLP DQKVC