LMO4_HUMAN
ID LMO4_HUMAN Reviewed; 165 AA.
AC P61968; D3DT23; O00158; O88894;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=LIM domain transcription factor LMO4;
DE AltName: Full=Breast tumor autoantigen;
DE AltName: Full=LIM domain only protein 4;
DE Short=LMO-4;
GN Name=LMO4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=10209267; DOI=10.1016/s0167-4781(99)00037-8;
RA Racevskis J., Dill A., Sparano J.A., Ruan H.;
RT "Molecular cloning of LMO4, a new human LIM domain gene.";
RL Biochim. Biophys. Acta 1445:148-153(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, Lung, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable transcriptional factor. {ECO:0000250}.
CC -!- SUBUNIT: Interacts strongly with LDBS. Interacts with DEAF1; LMO4
CC blocks export from nucleus. Interacts with CLIM1 and CLIM2. Interacts
CC (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1
CC (via the BRCT domains); the interaction represses BRCA1 transcriptional
CC activity (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC P61968; Q4LEZ3: AARD; NbExp=3; IntAct=EBI-2798728, EBI-5463075;
CC P61968; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-2798728, EBI-11096309;
CC P61968; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-2798728, EBI-10173507;
CC P61968; Q4VCS5-2: AMOT; NbExp=3; IntAct=EBI-2798728, EBI-3891843;
CC P61968; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-2798728, EBI-10187270;
CC P61968; A0A087WVE9: ARNT2; NbExp=3; IntAct=EBI-2798728, EBI-12808086;
CC P61968; Q8N9N5: BANP; NbExp=3; IntAct=EBI-2798728, EBI-744695;
CC P61968; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-2798728, EBI-11524452;
CC P61968; Q9BXC9: BBS2; NbExp=3; IntAct=EBI-2798728, EBI-748297;
CC P61968; O75934: BCAS2; NbExp=3; IntAct=EBI-2798728, EBI-1050106;
CC P61968; Q96CA5: BIRC7; NbExp=3; IntAct=EBI-2798728, EBI-517623;
CC P61968; Q86WS4: C12orf40; NbExp=3; IntAct=EBI-2798728, EBI-10286004;
CC P61968; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-2798728, EBI-739580;
CC P61968; Q68D86: CCDC102B; NbExp=6; IntAct=EBI-2798728, EBI-10171570;
CC P61968; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-2798728, EBI-744556;
CC P61968; Q96L14: CEP170P1; NbExp=3; IntAct=EBI-2798728, EBI-743488;
CC P61968; Q9Y2V7: COG6; NbExp=3; IntAct=EBI-2798728, EBI-3866319;
CC P61968; Q9UBG3: CRNN; NbExp=3; IntAct=EBI-2798728, EBI-3197866;
CC P61968; P43320: CRYBB2; NbExp=3; IntAct=EBI-2798728, EBI-974082;
CC P61968; P56545-3: CTBP2; NbExp=3; IntAct=EBI-2798728, EBI-10171902;
CC P61968; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-2798728, EBI-3867333;
CC P61968; P17661: DES; NbExp=3; IntAct=EBI-2798728, EBI-1055572;
CC P61968; Q16610: ECM1; NbExp=3; IntAct=EBI-2798728, EBI-947964;
CC P61968; Q2NKX8: ERCC6L; NbExp=3; IntAct=EBI-2798728, EBI-1042535;
CC P61968; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-2798728, EBI-371922;
CC P61968; Q86W67: FAM228A; NbExp=3; IntAct=EBI-2798728, EBI-12958227;
CC P61968; Q13643: FHL3; NbExp=3; IntAct=EBI-2798728, EBI-741101;
CC P61968; Q06547: GABPB1; NbExp=6; IntAct=EBI-2798728, EBI-618165;
CC P61968; Q08379: GOLGA2; NbExp=6; IntAct=EBI-2798728, EBI-618309;
CC P61968; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-2798728, EBI-5916454;
CC P61968; Q6ISB3: GRHL2; NbExp=7; IntAct=EBI-2798728, EBI-10219092;
CC P61968; A0A087WSW0: HELT; NbExp=3; IntAct=EBI-2798728, EBI-12057631;
CC P61968; O14964: HGS; NbExp=3; IntAct=EBI-2798728, EBI-740220;
CC P61968; O75031: HSF2BP; NbExp=3; IntAct=EBI-2798728, EBI-7116203;
CC P61968; Q02535: ID3; NbExp=3; IntAct=EBI-2798728, EBI-1387094;
CC P61968; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-2798728, EBI-11522367;
CC P61968; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-2798728, EBI-747204;
CC P61968; Q63ZY3: KANK2; NbExp=6; IntAct=EBI-2798728, EBI-2556193;
CC P61968; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-2798728, EBI-715394;
CC P61968; Q8N8K9: KIAA1958; NbExp=6; IntAct=EBI-2798728, EBI-10181113;
CC P61968; P19012: KRT15; NbExp=6; IntAct=EBI-2798728, EBI-739566;
CC P61968; Q15323: KRT31; NbExp=6; IntAct=EBI-2798728, EBI-948001;
CC P61968; Q14525: KRT33B; NbExp=3; IntAct=EBI-2798728, EBI-1049638;
CC P61968; O76011: KRT34; NbExp=5; IntAct=EBI-2798728, EBI-1047093;
CC P61968; O76015: KRT38; NbExp=3; IntAct=EBI-2798728, EBI-1047263;
CC P61968; Q6A163: KRT39; NbExp=3; IntAct=EBI-2798728, EBI-11958242;
CC P61968; Q6A162: KRT40; NbExp=3; IntAct=EBI-2798728, EBI-10171697;
CC P61968; Q7RTS7: KRT74; NbExp=3; IntAct=EBI-2798728, EBI-968660;
CC P61968; O95678: KRT75; NbExp=3; IntAct=EBI-2798728, EBI-2949715;
CC P61968; Q01546: KRT76; NbExp=3; IntAct=EBI-2798728, EBI-2952745;
CC P61968; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-2798728, EBI-1052037;
CC P61968; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-2798728, EBI-9996449;
CC P61968; Q16719-2: KYNU; NbExp=3; IntAct=EBI-2798728, EBI-12351611;
CC P61968; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-2798728, EBI-11985629;
CC P61968; Q14847-2: LASP1; NbExp=3; IntAct=EBI-2798728, EBI-9088686;
CC P61968; Q86U70: LDB1; NbExp=6; IntAct=EBI-2798728, EBI-677177;
CC P61968; Q86U70-2: LDB1; NbExp=8; IntAct=EBI-2798728, EBI-11979761;
CC P61968; O43679: LDB2; NbExp=6; IntAct=EBI-2798728, EBI-2865580;
CC P61968; P25791-3: LMO2; NbExp=3; IntAct=EBI-2798728, EBI-11959475;
CC P61968; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-2798728, EBI-1216080;
CC P61968; P59942: MCCD1; NbExp=3; IntAct=EBI-2798728, EBI-11987923;
CC P61968; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-2798728, EBI-8487781;
CC P61968; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-2798728, EBI-10172526;
CC P61968; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-2798728, EBI-11522433;
CC P61968; P15172: MYOD1; NbExp=3; IntAct=EBI-2798728, EBI-488878;
CC P61968; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-2798728, EBI-5662487;
CC P61968; O15049: N4BP3; NbExp=3; IntAct=EBI-2798728, EBI-2512055;
CC P61968; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-2798728, EBI-10271199;
CC P61968; Q13952-2: NFYC; NbExp=3; IntAct=EBI-2798728, EBI-11956831;
CC P61968; O00746: NME4; NbExp=3; IntAct=EBI-2798728, EBI-744871;
CC P61968; Q15233-2: NONO; NbExp=3; IntAct=EBI-2798728, EBI-10203843;
CC P61968; Q16656-4: NRF1; NbExp=3; IntAct=EBI-2798728, EBI-11742836;
CC P61968; Q5VU43: PDE4DIP; NbExp=4; IntAct=EBI-2798728, EBI-1105124;
CC P61968; Q9BRX2: PELO; NbExp=3; IntAct=EBI-2798728, EBI-1043580;
CC P61968; O15055: PER2; NbExp=3; IntAct=EBI-2798728, EBI-1054296;
CC P61968; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-2798728, EBI-12000762;
CC P61968; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-2798728, EBI-2798044;
CC P61968; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-2798728, EBI-1210429;
CC P61968; Q99708-2: RBBP8; NbExp=3; IntAct=EBI-2798728, EBI-10203615;
CC P61968; Q93062: RBPMS; NbExp=3; IntAct=EBI-2798728, EBI-740322;
CC P61968; Q15293: RCN1; NbExp=3; IntAct=EBI-2798728, EBI-948278;
CC P61968; O76064: RNF8; NbExp=3; IntAct=EBI-2798728, EBI-373337;
CC P61968; Q9HAT0: ROPN1; NbExp=3; IntAct=EBI-2798728, EBI-1378139;
CC P61968; Q9H0K4: RSPH6A; NbExp=3; IntAct=EBI-2798728, EBI-12169267;
CC P61968; Q16348: SLC15A2; NbExp=3; IntAct=EBI-2798728, EBI-12806032;
CC P61968; Q13485: SMAD4; NbExp=8; IntAct=EBI-2798728, EBI-347263;
CC P61968; P51692: STAT5B; NbExp=3; IntAct=EBI-2798728, EBI-1186119;
CC P61968; P51687: SUOX; NbExp=3; IntAct=EBI-2798728, EBI-3921347;
CC P61968; P15884: TCF4; NbExp=3; IntAct=EBI-2798728, EBI-533224;
CC P61968; P15884-3: TCF4; NbExp=3; IntAct=EBI-2798728, EBI-13636688;
CC P61968; Q8IWB6: TEX14; NbExp=3; IntAct=EBI-2798728, EBI-6674697;
CC P61968; Q9UBB9: TFIP11; NbExp=6; IntAct=EBI-2798728, EBI-1105213;
CC P61968; Q08117: TLE5; NbExp=3; IntAct=EBI-2798728, EBI-717810;
CC P61968; Q08117-2: TLE5; NbExp=3; IntAct=EBI-2798728, EBI-11741437;
CC P61968; Q13625-3: TP53BP2; NbExp=3; IntAct=EBI-2798728, EBI-10175039;
CC P61968; O00463: TRAF5; NbExp=3; IntAct=EBI-2798728, EBI-523498;
CC P61968; P14373: TRIM27; NbExp=3; IntAct=EBI-2798728, EBI-719493;
CC P61968; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-2798728, EBI-2130429;
CC P61968; Q6ZT98-3: TTLL7; NbExp=3; IntAct=EBI-2798728, EBI-13339851;
CC P61968; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-2798728, EBI-947187;
CC P61968; Q2NL98: VMAC; NbExp=3; IntAct=EBI-2798728, EBI-2803134;
CC P61968; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-2798728, EBI-2799833;
CC P61968; O43298: ZBTB43; NbExp=3; IntAct=EBI-2798728, EBI-740718;
CC P61968; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-2798728, EBI-12030590;
CC P61968; P52742: ZNF135; NbExp=3; IntAct=EBI-2798728, EBI-7101455;
CC P61968; O95125: ZNF202; NbExp=4; IntAct=EBI-2798728, EBI-751960;
CC P61968; O14771: ZNF213; NbExp=3; IntAct=EBI-2798728, EBI-12838388;
CC P61968; Q8NF99: ZNF397; NbExp=3; IntAct=EBI-2798728, EBI-10213894;
CC P61968; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-2798728, EBI-11741890;
CC P61968; Q7Z7K2: ZNF467; NbExp=3; IntAct=EBI-2798728, EBI-11986485;
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DR EMBL; U24576; AAB51073.1; -; mRNA.
DR EMBL; CH471097; EAW73168.1; -; Genomic_DNA.
DR EMBL; CH471097; EAW73169.1; -; Genomic_DNA.
DR EMBL; BC003600; AAH03600.1; -; mRNA.
DR EMBL; BC017673; AAH17673.1; -; mRNA.
DR EMBL; BC065818; AAH65818.1; -; mRNA.
DR CCDS; CCDS713.1; -.
DR RefSeq; NP_006760.1; NM_006769.3.
DR RefSeq; XP_005271348.1; XM_005271291.3.
DR PDB; 2L4Z; NMR; -; A=16-82.
DR PDBsum; 2L4Z; -.
DR AlphaFoldDB; P61968; -.
DR BMRB; P61968; -.
DR SMR; P61968; -.
DR BioGRID; 114113; 148.
DR CORUM; P61968; -.
DR DIP; DIP-41414N; -.
DR IntAct; P61968; 136.
DR MINT; P61968; -.
DR STRING; 9606.ENSP00000359575; -.
DR iPTMnet; P61968; -.
DR PhosphoSitePlus; P61968; -.
DR BioMuta; LMO4; -.
DR EPD; P61968; -.
DR jPOST; P61968; -.
DR MassIVE; P61968; -.
DR MaxQB; P61968; -.
DR PaxDb; P61968; -.
DR PeptideAtlas; P61968; -.
DR PRIDE; P61968; -.
DR ProteomicsDB; 57350; -.
DR Antibodypedia; 33592; 305 antibodies from 34 providers.
DR DNASU; 8543; -.
DR Ensembl; ENST00000370542.1; ENSP00000359573.1; ENSG00000143013.13.
DR Ensembl; ENST00000370544.10; ENSP00000359575.4; ENSG00000143013.13.
DR GeneID; 8543; -.
DR KEGG; hsa:8543; -.
DR MANE-Select; ENST00000370544.10; ENSP00000359575.4; NM_006769.4; NP_006760.1.
DR UCSC; uc001dmi.4; human.
DR CTD; 8543; -.
DR DisGeNET; 8543; -.
DR GeneCards; LMO4; -.
DR HGNC; HGNC:6644; LMO4.
DR HPA; ENSG00000143013; Low tissue specificity.
DR MIM; 603129; gene.
DR neXtProt; NX_P61968; -.
DR OpenTargets; ENSG00000143013; -.
DR PharmGKB; PA30410; -.
DR VEuPathDB; HostDB:ENSG00000143013; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000157730; -.
DR HOGENOM; CLU_001357_7_1_1; -.
DR InParanoid; P61968; -.
DR OMA; NNVVRCC; -.
DR OrthoDB; 1307952at2759; -.
DR PhylomeDB; P61968; -.
DR TreeFam; TF351071; -.
DR PathwayCommons; P61968; -.
DR SignaLink; P61968; -.
DR BioGRID-ORCS; 8543; 22 hits in 1082 CRISPR screens.
DR ChiTaRS; LMO4; human.
DR EvolutionaryTrace; P61968; -.
DR GeneWiki; LMO4; -.
DR GenomeRNAi; 8543; -.
DR Pharos; P61968; Tbio.
DR PRO; PR:P61968; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; P61968; protein.
DR Bgee; ENSG00000143013; Expressed in dorsolateral prefrontal cortex and 211 other tissues.
DR Genevisible; P61968; HS.
DR GO; GO:0031252; C:cell leading edge; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; ISS:UniProtKB.
DR GO; GO:0033674; P:positive regulation of kinase activity; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0050865; P:regulation of cell activation; IEA:Ensembl.
DR GO; GO:0042659; P:regulation of cell fate specification; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR IDEAL; IID00310; -.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; LIM domain; Metal-binding; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..165
FT /note="LIM domain transcription factor LMO4"
FT /id="PRO_0000075820"
FT DOMAIN 23..83
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 87..147
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT STRAND 21..29
FT /evidence="ECO:0007829|PDB:2L4Z"
FT STRAND 32..38
FT /evidence="ECO:0007829|PDB:2L4Z"
FT STRAND 41..44
FT /evidence="ECO:0007829|PDB:2L4Z"
FT TURN 45..47
FT /evidence="ECO:0007829|PDB:2L4Z"
FT TURN 51..53
FT /evidence="ECO:0007829|PDB:2L4Z"
FT HELIX 57..59
FT /evidence="ECO:0007829|PDB:2L4Z"
FT STRAND 67..69
FT /evidence="ECO:0007829|PDB:2L4Z"
FT HELIX 74..80
FT /evidence="ECO:0007829|PDB:2L4Z"
SQ SEQUENCE 165 AA; 17994 MW; C8AC295144AD7787 CRC64;
MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC SCCQAQLGDI
GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV MRAQGNVYHL KCFTCSTCRN
RLVPGDRFHY INGSLFCEHD RPTALINGHL NSLQSNPLLP DQKVC
