ID   LMP1_CAEEL              Reviewed;         237 AA.
AC   Q11117;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=LAMP family protein lmp-1;
DE   Flags: Precursor;
GN   Name=lmp-1; ORFNames=C03B1.12;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RX   PubMed=10862717; DOI=10.1242/jcs.113.14.2595;
RA   Kostich M., Fire A., Fambrough D.M.;
RT   "Identification and molecular-genetic characterization of a LAMP/CD68-like
RT   protein from Caenorhabditis elegans.";
RL   J. Cell Sci. 113:2595-2606(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00740};
CC       Single-pass type I membrane protein {ECO:0000255|PROSITE-
CC       ProRule:PRU00740}.
CC   -!- DEVELOPMENTAL STAGE: Present from early embryonic stages through
CC       adulthood.
CC   -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00740}.
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DR   EMBL; AF186848; AAD56712.1; -; mRNA.
DR   EMBL; FO080304; CCD62744.1; -; Genomic_DNA.
DR   PIR; T15389; T15389.
DR   RefSeq; NP_509072.1; NM_076671.4.
DR   AlphaFoldDB; Q11117; -.
DR   SMR; Q11117; -.
DR   BioGRID; 45842; 1.
DR   STRING; 6239.C03B1.12; -.
DR   EPD; Q11117; -.
DR   PaxDb; Q11117; -.
DR   PeptideAtlas; Q11117; -.
DR   EnsemblMetazoa; C03B1.12.1; C03B1.12.1; WBGene00003053.
DR   GeneID; 180912; -.
DR   KEGG; cel:CELE_C03B1.12; -.
DR   UCSC; C03B1.12.1; c. elegans.
DR   CTD; 180912; -.
DR   WormBase; C03B1.12; CE03912; WBGene00003053; lmp-1.
DR   eggNOG; KOG4818; Eukaryota.
DR   HOGENOM; CLU_1215950_0_0_1; -.
DR   InParanoid; Q11117; -.
DR   OMA; CYLDART; -.
DR   OrthoDB; 1330331at2759; -.
DR   PhylomeDB; Q11117; -.
DR   Reactome; R-CEL-114608; Platelet degranulation.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   PRO; PR:Q11117; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00003053; Expressed in embryo and 4 other tissues.
DR   GO; GO:0044841; C:gut granule membrane; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IDA:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
DR   GO; GO:0043227; C:membrane-bounded organelle; IDA:WormBase.
DR   GO; GO:0045335; C:phagocytic vesicle; IDA:WormBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0072594; P:establishment of protein localization to organelle; IBA:GO_Central.
DR   InterPro; IPR002000; Lysosome-assoc_membr_glycop.
DR   PANTHER; PTHR11506; PTHR11506; 1.
DR   PRINTS; PR00336; LYSASSOCTDMP.
DR   PROSITE; PS51407; LAMP_3; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..237
FT                   /note="LAMP family protein lmp-1"
FT                   /id="PRO_0000017115"
FT   TOPO_DOM        18..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT   TOPO_DOM        226..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        50
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   237 AA;  25792 MW;  E701B33757A886AD CRC64;
     MLKSFVILFA FLASASATAS HYYVTNNNTG LTCIILDGDF QFNLVFNEKN TTEKFTVTFN
     ETVSVEGDCN GVRNNQSVQT LNIKFNPEGQ SARYAKEWEL DIVFGSSSNV AFEIIDYTLT
     TQRTDLVPYF GKFVRDANAA GDVTATQTNA YKCSTAKLGL VGGSTIDIKT SNVIAFAQMN
     GTVFPTDQVY EVCYLDARTN EVVPIVVGAC LAALVVVVLV GYLIGRARAK RQGYASV