ID   LMRA_STRLN              Reviewed;         481 AA.
AC   P46104;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Lincomycin resistance protein;
GN   Name=lmrA;
OS   Streptomyces lincolnensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=78-11;
RX   PubMed=1328813; DOI=10.1111/j.1365-2958.1992.tb01388.x;
RA   Zhang H.Z., Schmidt H., Piepersberg W.;
RT   "Molecular cloning and characterization of two lincomycin-resistance genes,
RT   lmrA and lmrB, from Streptomyces lincolnensis 78-11.";
RL   Mol. Microbiol. 6:2147-2157(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=78-11;
RX   PubMed=8577249; DOI=10.1111/j.1365-2958.1995.tb02338.x;
RA   Peschke U., Schmidt H., Zhang H.Z., Piepersberg W.;
RT   "Molecular characterization of the lincomycin-production gene cluster of
RT   Streptomyces lincolnensis 78-11.";
RL   Mol. Microbiol. 16:1137-1156(1995).
CC   -!- FUNCTION: Proton-dependent transporter. May mediate the efflux of
CC       lincomycin.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; X59926; CAA42550.1; -; Genomic_DNA.
DR   EMBL; X79146; CAA55745.1; -; Genomic_DNA.
DR   PIR; S69808; S69808.
DR   AlphaFoldDB; P46104; -.
DR   SMR; P46104; -.
DR   STRING; 1915.SLINC_0232; -.
DR   TCDB; 2.A.1.3.9; the major facilitator superfamily (mfs).
DR   KEGG; ag:CAA42550; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..481
FT                   /note="Lincomycin resistance protein"
FT                   /id="PRO_0000173327"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   481 AA;  50421 MW;  DBF494C51D7B6F17 CRC64;
     MSVFARATSL FSRAARTRAA DEAARSRSRW VTLVFLAVLQ LLIAVDVTVV NIALPAIRDS
     FHVDTRQLTW VVTGYTVVGG GLLMVGGRIA DLFGRRRTLL FGAFLFGASS LAAGLAPNLE
     LLVLARFGQG AGEALSLPAA MSLIACSSRT APFQGVERLA SVASVGLVLG FLLSGVITQL
     FSWRWIFLIN IPLVSLVLVA VLLLVKKDET TARNPVDLPG ALLFTAAPLL LIFGVNELGE
     DEPRLPLAVG SLLAAAVCAA AFVAVERRTA HPLVPLTFFG NRVRLVANGA TVLLSAALST
     SFFLLTMHLQ EERDLSPIEA GLSFLPLGLS LILACVLVRG LIERIGTTGA AVLGMALAGP
     RHRLFALLPS DNSLLTSVFP GMILLLRMAT GLVALQNAAL HAVTEADAGV ASGVQRCADQ
     LGGASGIAVY VSIGFSPHLG GDWDPFTVAY SLAGIGLIAA VLAVLALSPD RRLAAPREQE
     D