ID   LMRB_LISIN              Reviewed;         471 AA.
AC   Q92EE1;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Lincomycin resistance protein LmrB;
GN   Name=lmrB; OrderedLocusNames=lin0519;
OS   Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=272626;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-680 / CLIP 11262;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Proton-dependent transporter. May mediate the efflux of
CC       lincomycin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC       {ECO:0000305}.
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DR   EMBL; AL596165; CAC95751.1; -; Genomic_DNA.
DR   PIR; AG1497; AG1497.
DR   RefSeq; WP_010990459.1; NC_003212.1.
DR   AlphaFoldDB; Q92EE1; -.
DR   SMR; Q92EE1; -.
DR   STRING; 272626.lin0519; -.
DR   EnsemblBacteria; CAC95751; CAC95751; CAC95751.
DR   GeneID; 61169553; -.
DR   KEGG; lin:lin0519; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_000960_28_0_9; -.
DR   OMA; HWIFWIS; -.
DR   OrthoDB; 1108236at2; -.
DR   Proteomes; UP000002513; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..471
FT                   /note="Lincomycin resistance protein LmrB"
FT                   /id="PRO_0000173329"
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   471 AA;  50368 MW;  525BFAB865937224 CRC64;
     MQQEATGGQK IRPIPIIASF LMAGFIGLFS ETALNMALSD LIQVFDISSA TVQWLTTGYL
     LTLGILVPIS GLLLQWFTTR GLFFTAVSFS IAGTLIAALS PTFAMLMIGR VVQAVGTALL
     LPLMFNTILL IFPEHKRGSA MGMIGLVIMF APAVGPTISG LILENLTWNW IFWISLPFLI
     IALLFGMKFM QNVSVVTKPK IDILSIILST LGFGGVVFAF SSAGENGWGS ATVLVSIIVG
     GIALGLFVWR QLTMEKPLMD LKVFKYPMFT LGLILVFISF MMILSTMILL PLYLQNSLAL
     AAFSAGLVLL PGGVLNGLMS PFTGRLFDAY GPRALVIPGF IVAVIALFFL TRIEVGTSAL
     TIIVLHSVLM IGISMVMMPA QTNGLNQLPP KLYPDGTAIM NTLQQVSGAI GTAVAITIMS
     AGQKAYMETA QGVGPEQMIA SLTAGIQNAF VFGLIMACIG LLCSLFIRKA K