ID   LMRB_LISMO              Reviewed;         471 AA.
AC   Q8Y9K8;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Lincomycin resistance protein LmrB;
GN   Name=lmrB; OrderedLocusNames=lmo0519;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Proton-dependent transporter. May mediate the efflux of
CC       lincomycin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC       {ECO:0000305}.
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DR   EMBL; AL591975; CAC98598.1; -; Genomic_DNA.
DR   PIR; AH1139; AH1139.
DR   RefSeq; NP_464047.1; NC_003210.1.
DR   RefSeq; WP_009931218.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q8Y9K8; -.
DR   SMR; Q8Y9K8; -.
DR   STRING; 169963.lmo0519; -.
DR   PaxDb; Q8Y9K8; -.
DR   EnsemblBacteria; CAC98598; CAC98598; CAC98598.
DR   GeneID; 985272; -.
DR   KEGG; lmo:lmo0519; -.
DR   PATRIC; fig|169963.11.peg.538; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_000960_28_0_9; -.
DR   OMA; HWIFWIS; -.
DR   PhylomeDB; Q8Y9K8; -.
DR   BioCyc; LMON169963:LMO0519-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..471
FT                   /note="Lincomycin resistance protein LmrB"
FT                   /id="PRO_0000173330"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   471 AA;  50313 MW;  637F312877061DFD CRC64;
     MQQEATGGQK IRPIPIIASF LMAGFIGLFS ETALNMALSD LIQVFDISSA TVQWLTTGYL
     LTLGILVPIS GLLLQWFTTR GLFFTAVSFS IAGTLIAALS PTFAMLMIGR VVQAVGTALL
     LPLMFNTILL IFPEHKRGSA MGMIGLVIMF APAVGPTISG LILENLTWNW IFWISLPFLI
     IALLFGMKFM QNVSVVTKPK IDILSIILST LGFGGVVFAF SSAGESGWGS ATVLVSIIVG
     GIALGLFVWR QLTMEKPLMD LKVFKYPMFT LGLILVFISF MMILSTMILL PLYLQNSLAL
     AAFSAGLVLL PGGVLNGLMS PFTGRLFDAY GPRALVIPGF IVAVVALFFL TRIEVGTSAL
     TIIVLHSVLM IGISMVMMPA QTNGLNQLPP KLYPDGTAIM NTLQQVSGAI GTAVAITIMS
     AGQKAYMETA QGVGPEQMVA SLTAGIQNAF VFGLIMACIG LLCSLFIRKA K