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LMTD1_MOUSE
ID   LMTD1_MOUSE             Reviewed;         413 AA.
AC   Q9D4C1; Q5UE52;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Lamin tail domain-containing protein 1;
DE   AltName: Full=Intermediate filament tail domain-containing protein 1;
DE   AltName: Full=Lamin-A-related sequence 1 protein;
GN   Name=Lmntd1; Synonyms=Ifltd1, Lmna-rs1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=A/J; TISSUE=Lung;
RA   Manenti G., Galbiati F., Pettinicchio A., Dragani T.A.;
RT   "Complex in vitro allelic effects of mouse Pas1 candidate genes in human
RT   lung cancer cell lines.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the intermediate filament family. {ECO:0000305}.
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DR   EMBL; AY753326; AAV31718.1; -; mRNA.
DR   EMBL; AK016641; BAB30353.1; -; mRNA.
DR   EMBL; BC053420; AAH53420.1; -; mRNA.
DR   CCDS; CCDS20695.1; -.
DR   RefSeq; NP_083018.1; NM_028742.2.
DR   RefSeq; XP_017177272.1; XM_017321783.1.
DR   RefSeq; XP_017177273.1; XM_017321784.1.
DR   RefSeq; XP_017177274.1; XM_017321785.1.
DR   RefSeq; XP_017177275.1; XM_017321786.1.
DR   RefSeq; XP_017177276.1; XM_017321787.1.
DR   RefSeq; XP_017177277.1; XM_017321788.1.
DR   AlphaFoldDB; Q9D4C1; -.
DR   SMR; Q9D4C1; -.
DR   STRING; 10090.ENSMUSP00000107337; -.
DR   PhosphoSitePlus; Q9D4C1; -.
DR   PaxDb; Q9D4C1; -.
DR   PRIDE; Q9D4C1; -.
DR   ProteomicsDB; 292343; -.
DR   Antibodypedia; 42350; 116 antibodies from 21 providers.
DR   DNASU; 74071; -.
DR   Ensembl; ENSMUST00000111708; ENSMUSP00000107337; ENSMUSG00000054966.
DR   GeneID; 74071; -.
DR   KEGG; mmu:74071; -.
DR   UCSC; uc009ero.1; mouse.
DR   CTD; 160492; -.
DR   MGI; MGI:1921321; Lmntd1.
DR   VEuPathDB; HostDB:ENSMUSG00000054966; -.
DR   eggNOG; KOG0977; Eukaryota.
DR   GeneTree; ENSGT00910000144343; -.
DR   InParanoid; Q9D4C1; -.
DR   OMA; HWKQVWE; -.
DR   OrthoDB; 716378at2759; -.
DR   PhylomeDB; Q9D4C1; -.
DR   TreeFam; TF338357; -.
DR   BioGRID-ORCS; 74071; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Lmntd1; mouse.
DR   PRO; PR:Q9D4C1; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q9D4C1; protein.
DR   Bgee; ENSMUSG00000054966; Expressed in interventricular septum and 44 other tissues.
DR   ExpressionAtlas; Q9D4C1; baseline and differential.
DR   Genevisible; Q9D4C1; MM.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0008283; P:cell population proliferation; IDA:MGI.
DR   Gene3D; 2.60.40.1260; -; 1.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   InterPro; IPR036415; Lamin_tail_dom_sf.
DR   InterPro; IPR042840; LMNTD1.
DR   PANTHER; PTHR47012; PTHR47012; 1.
DR   Pfam; PF00932; LTD; 1.
DR   SUPFAM; SSF74853; SSF74853; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   2: Evidence at transcript level;
KW   Intermediate filament; Reference proteome.
FT   CHAIN           1..413
FT                   /note="Lamin tail domain-containing protein 1"
FT                   /id="PRO_0000317249"
FT   DOMAIN          169..287
FT                   /note="LTD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        218
FT                   /note="H -> R (in Ref. 1; AAV31718)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        258
FT                   /note="E -> G (in Ref. 1; AAV31718)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   413 AA;  45937 MW;  02EB148B74948CF4 CRC64;
     MMKEASEPLA SVTSINKQDS KVQDGEIRKE KIGTITPSKQ HSSVHFFPKI MDSDSTTLIP
     LSRSFSQEMP IGFYQITSTQ NSSTLSSRGQ LASKSTILSC SHKDSSLGKQ STSSMVPRRQ
     PQSSSDVDTY TFGNGEDYFL SLFGESKKLT AHTPQAENVS EHLSVILEEV GQFTSSSLGE
     IKIAEVNIKG LFVRLVNSSN EKEVEIGNHI LQQNVNGHAV SLYQFPDNIT LQANSTVTVW
     AAASEAKPQP PTDFVWEEQS KFRSSPDCTT ILCKPNGEAI AWYTPIHWKQ AWEKLETDIE
     FERCSVVVPS MRNHMFGWIT ASVSSTNEEK EEPIQKTPSQ VYPVLYREKE IPPTVLPNKS
     PWCRNPNTSP HPYSSLIDSH DSDISESSLD TQLKPQPTKP KPDPGTKKKK AKS
 
 
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