LMTD2_HUMAN
ID LMTD2_HUMAN Reviewed; 634 AA.
AC Q8IXW0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Lamin tail domain-containing protein 2;
GN Name=LMNTD2; Synonyms=C11orf35;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-44.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IXW0; Q6ZUJ4: C3orf62; NbExp=3; IntAct=EBI-12028858, EBI-2837036;
CC Q8IXW0; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12028858, EBI-3867333;
CC Q8IXW0; P23142-4: FBLN1; NbExp=3; IntAct=EBI-12028858, EBI-11956479;
CC Q8IXW0; Q0VD86: INCA1; NbExp=3; IntAct=EBI-12028858, EBI-6509505;
CC Q8IXW0; Q5VWX1: KHDRBS2; NbExp=3; IntAct=EBI-12028858, EBI-742808;
CC Q8IXW0; O75525: KHDRBS3; NbExp=3; IntAct=EBI-12028858, EBI-722504;
CC Q8IXW0; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-12028858, EBI-3044087;
CC Q8IXW0; Q15323: KRT31; NbExp=3; IntAct=EBI-12028858, EBI-948001;
CC Q8IXW0; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-12028858, EBI-11953334;
CC Q8IXW0; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-12028858, EBI-11958178;
CC Q8IXW0; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-12028858, EBI-10250562;
CC Q8IXW0; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-12028858, EBI-1044640;
CC Q8IXW0; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-12028858, EBI-1043191;
CC Q8IXW0; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-12028858, EBI-10172526;
CC Q8IXW0; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-12028858, EBI-22310682;
CC Q8IXW0; P0DJD3-2: RBMY1A1; NbExp=3; IntAct=EBI-12028858, EBI-11994018;
CC Q8IXW0; Q3MII6: TBC1D25; NbExp=3; IntAct=EBI-12028858, EBI-11899977;
CC Q8IXW0; Q63HR2: TNS2; NbExp=3; IntAct=EBI-12028858, EBI-949753;
CC Q8IXW0; Q13077: TRAF1; NbExp=3; IntAct=EBI-12028858, EBI-359224;
CC Q8IXW0; Q12933: TRAF2; NbExp=3; IntAct=EBI-12028858, EBI-355744;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP006284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039077; AAH39077.1; -; mRNA.
DR CCDS; CCDS7701.1; -.
DR RefSeq; NP_775844.2; NM_173573.2.
DR AlphaFoldDB; Q8IXW0; -.
DR SMR; Q8IXW0; -.
DR BioGRID; 129158; 18.
DR IntAct; Q8IXW0; 21.
DR STRING; 9606.ENSP00000331167; -.
DR iPTMnet; Q8IXW0; -.
DR PhosphoSitePlus; Q8IXW0; -.
DR BioMuta; LMNTD2; -.
DR DMDM; 317373345; -.
DR MassIVE; Q8IXW0; -.
DR PaxDb; Q8IXW0; -.
DR PeptideAtlas; Q8IXW0; -.
DR PRIDE; Q8IXW0; -.
DR ProteomicsDB; 71069; -.
DR Antibodypedia; 70549; 9 antibodies from 4 providers.
DR DNASU; 256329; -.
DR Ensembl; ENST00000329451.8; ENSP00000331167.3; ENSG00000185522.9.
DR Ensembl; ENST00000621319.2; ENSP00000478197.1; ENSG00000275873.2.
DR GeneID; 256329; -.
DR KEGG; hsa:256329; -.
DR MANE-Select; ENST00000329451.8; ENSP00000331167.3; NM_173573.3; NP_775844.2.
DR UCSC; uc001lpx.4; human.
DR CTD; 256329; -.
DR DisGeNET; 256329; -.
DR GeneCards; LMNTD2; -.
DR HGNC; HGNC:28561; LMNTD2.
DR HPA; ENSG00000185522; Tissue enhanced (liver, testis).
DR neXtProt; NX_Q8IXW0; -.
DR OpenTargets; ENSG00000185522; -.
DR PharmGKB; PA142672302; -.
DR VEuPathDB; HostDB:ENSG00000185522; -.
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00390000012150; -.
DR HOGENOM; CLU_432519_0_0_1; -.
DR InParanoid; Q8IXW0; -.
DR OMA; VWGEGTR; -.
DR OrthoDB; 983450at2759; -.
DR PhylomeDB; Q8IXW0; -.
DR TreeFam; TF337768; -.
DR PathwayCommons; Q8IXW0; -.
DR SignaLink; Q8IXW0; -.
DR BioGRID-ORCS; 256329; 11 hits in 1060 CRISPR screens.
DR GenomeRNAi; 256329; -.
DR Pharos; Q8IXW0; Tdark.
DR PRO; PR:Q8IXW0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8IXW0; protein.
DR Bgee; ENSG00000185522; Expressed in right uterine tube and 88 other tissues.
DR ExpressionAtlas; Q8IXW0; baseline and differential.
DR Genevisible; Q8IXW0; HS.
DR GO; GO:0005638; C:lamin filament; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IBA:GO_Central.
DR GO; GO:0010847; P:regulation of chromatin assembly; IBA:GO_Central.
DR Gene3D; 2.60.40.1260; -; 1.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR Pfam; PF00932; LTD; 1.
DR SUPFAM; SSF74853; SSF74853; 1.
DR PROSITE; PS51841; LTD; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..634
FT /note="Lamin tail domain-containing protein 2"
FT /id="PRO_0000251929"
FT DOMAIN 350..468
FT /note="LTD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 106..169
FT /evidence="ECO:0000255"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..570
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 44
FT /note="A -> T (in dbSNP:rs2061586)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027732"
SQ SEQUENCE 634 AA; 70379 MW; 919B27D64FC8B6E3 CRC64;
MRWLRPAGRR REQESVSGHL GPPAGAPAAP ETPTCLPDTT PHPAPVVCSA DPQLALESLD
PRTLRLLWRQ RELEIQALRW AIQNGEDARL CHILEEVAGL PPKRSSHSQE KLLQNQVQKL
IQELKEQKER AQWEKEHLEE RLLQTTRTLQ EMEAELQNLQ KSCLLQLARS SWVGRMLRSQ
TGSVEVVTAE TLMDPSDLSE NIQAPTGEGF RLEDVDWNSV ARRYPNLFTN MEPSSKQKQP
RPWPQLDTGS PESSGKHSER HHKTVEWGSL PCLNTSSSGG ADSDSSSCRP GLPSFVQVIG
HPPRDHRASS EQALVQAGSY SRDSEDLQKT HSPRHGEPVL SPQPCTDPDH WSPELLQSPT
GLKIVAVSCR EKFVRIFNPS QESTADLSGM VLKQLVRGFP ERLYRFPPGT LLAPRHHVTV
WGEATRSAKK PLRASSSREP VPLLSIRGCA TLLLSPKGEV LSEHRIPRRE TPAPRVFADG
TDLSIDRFPL PEAGPGADTR KPPRPPRPLR KGRVREPRVS RRRPGTRGLL PPVSSGKLFH
AREGPARPEN PEIPAPQHLP AIPGDPTLPS PPAEAGLGLE DCRLQKEHRV RVCRKSVDRS
CPLVALSVQN TAESRFGFRF LSCLPVTADT CRGA
